Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis

Okur, Neslihan Üstündağ; Gökçe, Evren; Bozbıyık, Duygu İnci; Eğrilmez, Sait; Ertan, Gökhan; Özer, Özgen

doi:10.1517/17425247.2015.1059419

Cited by 71 publications

(32 citation statements)

References 51 publications

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“…Experiments to measure the particle size and PDI values were repeated five times at 25 °C. The results were obtained by averaging of five measurements at an angle of 173° by using disposable cells [25]. In order to measure the zeta potential of samples, disposable plain folded capillary zeta cells (Malvern Zetasizer Nano ZS) were used.…”

Section: Characterization Of Microemulsion Formulationsmentioning

confidence: 99%

Preparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment

Okur¹,

Çağlar²,

Pekcan³

et al. 2019

jrp

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The aim of the study is to evaluate the strengthening of penetration of the epidermis through the formulas containing hydroquinone in melasma treatment and development of alternative new carrier systems. During preparation of hydroquinone loaded microemulsions, isopropyl myristate (IPM) as oil phase, Cremophor EL, Span 20, Span 80 and Tween 20 as surfactant, ethanol as co-surfactant, distilled water as aqueous phase were used. Furthermore, in vitro drug release studies were performed. As results of the study, it was measured that conductivity between 16 ± 2.51 and 42.1 ± 2.67, viscosity between 8.97 ± 0.082 and 51.76 ± 0.04, pH between 3.3 ± 0.436 and 5.7 ± 0.2 and refractive index between 1.4032 ± 0.0002 and 1.4299 ± 0.0002. Formulations showed that zeta potential between -0.461 ± 0.009 and 0.359 ± 0.223, PDI between 0.08 ± 0.02 and 0.196 ± 0.067, and droplet size between 24.27 ± 3.559 and 324.9 ± 16.8 nm. Moreover, in vitro drug release studies showed that formulation M2 released 87.405 % of the drug at the end of the 24h. According to results of histopathological analysis, formulations were found convenient for the usage. According to results of our study, hydroquinone loaded microemulsions can be seen as a promising alternative for the treatment of melasma disease.

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Section: Characterization Of Microemulsion Formulationsmentioning

confidence: 99%

Preparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment

Okur¹,

Çağlar²,

Pekcan³

et al. 2019

jrp

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“…The detection was performed at 330 nm (Gulsoy-Toplan et al 2018). The HPLC method was validated based on the experimental results; linearity, selectivity, LOD, LOQ, accuracy, precision, RSD, recovery and robustness (Üstündağ- Okur et al 2015;Okur et al 2018b). The quercetin concentration in each extract was calculated by the following regression equation y= 59671x-18,47 with good linearity (r 2 =0.9996).…”

Section: Qualitative and Quantitative Chromatographic Analysis With Lmentioning

confidence: 99%

Investigation of Antioxidant and Cytotoxic Activities of Opuntia ficus-indica (L.) Mill. Fruit extract

Okur¹,

Karakaş²,

Karadağ³

et al. 2019

Istanbul J Pharm

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Opuntia ficus-indica (L.) Miller (Prickly pear cactus) is located in the Mediterranean and Aegean Region and belongs to the Cactaceae family (Kabas et al. 2006). This species is known as "kaynana dili, firenk inciri, hint inciri" in Turkey (Güner et al. 2012) and as "prickly pear" elsewhere in the world. The nutritional properties of this species have long been known. In Mediterranean countries, cladodes are not typically consumed as nutrients, but the fruits are largely consumed due to natural antioxidants which are may be protective against oxidative damage (Lee et al. 2002). The fruits are used also in traditional medicine for their hypolipidemic and hypoglycemic actions (Butera et al. 2002). The phytochemical compounds of prickly pear fruits and cladodes are vitamins, carotenoids, betalains, and polyphenolic compounds which have proven biological activities and health benefits (anti-cancer, anti-diabetic, anti-inflammatory, neuroprotective effect) (Ammar et al. 2018; Mena et al. 2018). OFI is especially rich in flavonoids and phenolic compounds. Due to the high amount of these substances the prickly pear fruit has a potent antioxidant activity (Butera et al. 2002; Lee et al. 2002; Investigation of antioxidant and cytotoxic activities of Opuntia ficus-indica (L.

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“…95,96 Bakteriyel keratit tedavisinde kullanılmak üzere geliştirilen insertler üzerinde yapılan bir çalışmada, ofloksasin yüklü nanoyapılı lipit taşıyıcıbazlı insert formülasyonları geliştirilmiştir. 97 Çalışmada, nanoyapılı lipit taşıyıcı sistemler yüksek basınçlı homojenizasyon yöntemi ile hazırlanır iken; insertler, çözücü dökme (solvent casting) tekniği ile hazırlanmıştır. Farklı formülasyon parametrelerinin incelendiği çalışmada, keratit oluşturulmuş tavşanlar üzerinde yapılan in vivo deneyler için plastizer olarak %5 gliserin içeren (lns3) ve %5 PEG 400 içeren (lns8) formülasyonlar seçilmiştir.…”

Section: İlaç Taşiyici Yeni̇ Si̇stemlerunclassified

Application of New Drug Delivery Systems for the Treatment of Bacterial Keratitis

Polat¹,

Pehlivan²,

Çalış³

2018

Turkiye Klinikleri J Ophthalmol

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Ö ÖZ ZE ET T Bakteriyel keratit; gözde farklı patojenlerin neden olduğu inflamasyon ile karakterize, tedavinin gerçekleşmediği durumlarda ciddi görme kayıplarına neden olabilen bir hastalıktır. Hastalığın semptomları arasında gözde kızarma, ağrı, görmede kayıp, korneal ülser oluşumu, anterior kısımda inflamasyon ve fotofobi bulunmaktadır. Hastalığa neden olan faktörler; kontak lens kullanımı gibi dış faktörler, oküler yüzey hastalıkları, korneal anomaliler ve şeker hastalığı, A vitamini eksikliği gibi sistemik hastalıklar olarak sıralanabilmektedir. Bakteriyel keratitin güncel tedavisinde antibiyotik içeren konvansiyonel göz damlaları tek başına veya lokal kortikosteroidlerle kombine olarak uygulanmaktadır. Bakteriyel keratit gibi oküler yüzey hastalıklarının tedavisinde; sistemik yoldan ilaç uygulanması, gözde yer alan kan-aköz bariyeri ve kan-retina bariyeri gibi engeller nedeni ile hedef bölgede istenen düzeyde ilaç miktarına ulaşılmasına imkân tanımamaktadır. Hedef bölgede istenen ilaç düzeyine ulaşılması için gerekli olan yüksek sistemik dozların uygulanması da hastada ciddi yan etkilere neden olmaktadır. Bu nedenle, topikal yoldan göze ilaç uygulanması bu problemlerin aşılmasında önemli bir çözüm yolu olarak görünmektedir. Ancak, topikal yoldan uygulanan konvansiyonel damla şeklindeki ilaç formülasyonlarında, uygulamanın gözün eşşiz savunma mekanizmaları (gözyaşı ile gözden atılma, enzimatik parçalanma, nazolakrimal drenaj ile uzaklaştırmaları vb.) nedeni ile hedeflenen başarının elde edilmesi zor olup, ileri formülasyon çalışmaları gerektirmektedir. Bu çalışmalar sonucunda elde edilen gelişmiş ilaç taşıyıcı sistemler, topikal yol ile ilaç uygulanması ile hedef bölgede istenen sonucun elde edilmesinde ümit vadetmektedir. Bu sistemler ile ilacın göz yüzeyinde kalış süresi artırılarak hedefe ulaşılması amaçlanmaktadır. Son zamanlarda; literatürde bu amaç için geliştirilen ilaç taşıyıcı sistemler arasında lipozom, ön ilaç, mikropartikül, nanopartikül, misel, mikro-nano emülsiyon ve insert gibi sistemler dikkat çekmektedir.A An na ah ht ta ar r K Ke el li im me el le er r: : Keratit; uygulama, topical; ilaç dağıtım sistemleri A AB BS ST TR RA AC CT T Bacterial keratitis is a disease characterized by inflammation caused by different pathogens in the eye, if the disease is not treated, it can cause severe vision loss. Symptoms of the disease include redness in the eye, pain, loss of sight, corneal ulcer formation, inflammation in the anterior part and photophobia. Some external factors such as contact lens use, ocular surface diseases, corneal anomalies and systemic diseases such as diabetes and vitamin A deficiency can be cited as factors causing the disease. In the current treatment of bacterial keratitis, conventional eye drops containing antibiotics are administered alone or in combination with local corticosteroids. In the treatment of ocular surface diseases such as bacterial keratitis, systemic administration of drugs does not allow the desired amount of drug to be reached in the target area due to obstacl...

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Novel nanostructured lipid carrier-based inserts for controlled ocular drug delivery: evaluation of corneal bioavailability and treatment efficacy in bacterial keratitis

Abstract: NLC-based inserts developed with COL and glycerin may be offered as appropriate vehicles for ocular delivery.

Cited by 71 publications

References 51 publications

Preparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment

Preparation, optimization and in vivo anti-inflammatory evaluation of hydroquinone loaded microemulsion formulations for melasma treatment

Investigation of Antioxidant and Cytotoxic Activities of Opuntia ficus-indica (L.) Mill. Fruit extract

Application of New Drug Delivery Systems for the Treatment of Bacterial Keratitis

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