Novel nanotechnological approaches for treatment of skin-aging

Sharma, Ashmita; Kuhad, Anurag; Bhandari, Ranjana

doi:10.1016/j.jtv.2022.04.010

Cited by 28 publications

(15 citation statements)

References 66 publications

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“…5 Based on these characteristics, LNPs have been utilized for the vaccines against COVID-19 1,6–8 and liposomes are widely used in pharmaceutical products such as Doxil, 1,6,9 AmBisome, 6,10 and cosmetic products. 11…”

Section: Introductionmentioning

confidence: 99%

“…5 Based on these characteristics, LNPs have been utilized for the vaccines against COVID-19 1,6-8 and liposomes are widely used in pharmaceutical products such as Doxil, 1,6,9 AmBisome, 6,10 and cosmetic products. 11 The most basic Lb-NPs are liposomes, which are enclosed vesicles consisting of one or more lipid bilayers. The size of such liposomes can be adjusted from nano-to micro-order, depending on the target organ/cells for delivery and the site of application.…”

Section: Introductionmentioning

confidence: 99%

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Controlling lamellarity and physicochemical properties of liposomes prepared using a microfluidic device

et al. 2023

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Controlling lamellarity and physicochemical properties of liposomes prepared using a microfluidic device

et al. 2023

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“…Therefore, there is an increasing need to develop technology to observe skin aging characteristics to maintain healthy skin and prevent skin diseases. As such, anti‐aging is receiving attention as a major interest worldwide, and research on skin aging prevention and management is increasing the skin, an essential external organ of the body 3 …”

Section: Introductionmentioning

confidence: 99%

Correlation analysis between texture features and elasticity of skin hyperspectral images in the near‐infrared band

Kim,

Lee

2024

Skin Research and Technology

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Background/purposeSkin elasticity was used to evaluate healthy and diseased skin. Correlation analysis between image texture characteristics and skin elasticity was performed to study the feasibility of assessing skin elasticity using a non‐contact method.Materials and methodsSkin images in the near‐infrared band were acquired using a hyperspectral camera, and skin elasticity was obtained using a skin elastimeter. Texture features of the mean, standard deviation, entropy, contrast, correlation, homogeneity, and energy were extracted from the acquired skin images, and a correlation analysis with skin elasticity was performed.ResultsThe texture features, and skin elasticity of skin images in the near‐infrared band had the highest correlation on the side of eye and under of arm, and the mean and correlation were features of texture suitable for distinguishing skin elasticity according to the body part.ConclusionIn this study, we performed elasticity and correlation analyses for various body parts using the texture characteristics of skin hyperspectral images in the near‐infrared band, confirming a significant correlation in some body parts. It is expected that this will be used as a cornerstone of skin elasticity evaluation research using non‐contact methods.

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“…The ethosomes are then produced from the combination of ethanol, propylene glycol, phospholipids, and water [ 20 ]. Structurally, ethosomes are like liposomes, which is a conventional drug delivery system consisting of layered lipids, but ethosomes contain higher concentration of ethanol than ethosomes [ 22 ]. Thanks to their enhanced physicochemical characteristics (e.g., stability, EE), ethosomes are suitable for the efficient transport, controlled and tissue-targeting drug delivery of lipophilic, hydrophilic, and amphiphilic drugs into deep layers of skin [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

Fabrication of Ethosomes Containing Tocopherol Acetate to Enhance Transdermal Permeation: In Vitro and Ex Vivo Characterizations

Akhtar

Menaa

et al. 2022

Gels

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Background: Tocopherol acetate (TA) is known as a skin moisturizing and photoprotective agent. One major drawback with tocopherol and its derivatives remains its limited stability. Aim: To develop highly stable TA-containing ethosomal gel (TAEG) as an advanced dosage form. Methods: A cold method technique was used to produce the ethosomes. An in vitro evaluation of viscosity, conductivity, and pH stability was carried out for three months. An in vitro physical characterization of the nanoparticles (NPs) that included particle size (PS), zeta potential (ZP), transmission electron microscopy (TEM), and Fourier-transform infrared (FTIR) spectroscopy analysis was then performed. Organoleptic evaluation, thermostability at 8 °C, 25 °C, 40 °C and 40 °C ± 75% RH, pH, conductivity, viscosity, and spreadability measurements were also performed in vitro for three months. An ex vivo permeation study was performed in phosphate-buffered solution (1× PBS; pH 5.5 or pH 7.4) at 37 ± 0.2 °C by using rat abdominal skin and the Franz diffusion cell method. The data of three independent experiments were expressed as mean ± SD. A two-way ANOVA was applied to compare data on TAEG versus TA control gel (TACG). Results: PS of the ethosomes was in the range of 144–289 nm. A total of nine formulations were developed. Optimized TAEG formulation (TA-5) was selected based on the highest entrapment efficiency (EE) of 99.71%, while the stability, the PS, and the uniformity-based polydispersity index (PDI) were also among the best. TA-5 exhibited smooth spherical ethosomal NPs with PS of 200.6 nm, ZP value of −18.6 V, and PDI of 0.465. Stability data obtained for TA-5 in terms of rheology, conductivity, and pH presented no significant change (p > 0.05) during the entire study duration. Rheological studies indicated that TA-5 followed a non-Newtonian behavior of shear thinning system. The ex vivo drug permeation was 44.55 ± 0.01% in TA-5 and the drug retention in skin was 51.20%, which was significantly higher than TACG as observed after 24 h permeation study (p < 0.05). Conclusions: The newly developed TAEG formulation appears promising to enhance the effectivity of TA and its topical application.

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Novel nanotechnological approaches for treatment of skin-aging

Cited by 28 publications

References 66 publications

Controlling lamellarity and physicochemical properties of liposomes prepared using a microfluidic device

Controlling lamellarity and physicochemical properties of liposomes prepared using a microfluidic device

Correlation analysis between texture features and elasticity of skin hyperspectral images in the near‐infrared band

Fabrication of Ethosomes Containing Tocopherol Acetate to Enhance Transdermal Permeation: In Vitro and Ex Vivo Characterizations

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