Novel Nanotechnological Strategies for Skin Anti-aging

Abstract

Background: Nanoparticle formulations development for anti-aging treatment is increasing due to their multifunctional properties. These nanotechnological strategies can target cellular/molecular pathways of the skin affected by the aging process. However, a review of these strategies is required to discuss their efficacy/safety and establish the needs for further research. Objective: Innovative nanotechnological advances for skin anti-aging/rejuvenation are summarized and discussed in this work. Method: The information in this review was extracted from recent and relevant studies using nanotechnology for anti-aging treatment from scientific databases. Results and discussion: Results show an enhanced skin anti-aging effect of actives-loaded nanoparticles of next generation (nanostructured lipid carriers, fullerenes, transfersomes, protransfersomes, niosomes, ethosomes, transethosomes, glycerosomes, phytosomes) compared with nanocarriers of first generation or conventional formulations. Anti-aging active ingredients such as, flavonoids (rutin, hesperidin, quercetagetine, quercetin, epigallocatechin-3-gallate, myricetin, silibinin, curcuminoids, isoflavones); vitamins (E, D3, CoQ10); acids (hyaluronic, ascorbic, rosmarinic, gallic); extracts (Citrus sinensis, Tagetes erecta L., Achillea millefolium L., Citrus aurantium L., Glycyrrhiza glabra L., Aloe vera, propolis earned by Apis mellifera); and other compounds (adenosine, beta-glucan, heptapetide DEETGEF, resveratrol, cycloastragenol, melatonin, botulinum toxin, grapeseed oil), have been successfully entrapped into nanoparticles for skin rejuvenation. This encapsulation has improved their solubility, bioavailability, stability, permeability, and effectivity for skin anti-aging, providing a controlled drug release with minimized side effects. Conclusion: Recent studies show a trend of anti-aging herbal active ingredients-loaded nanoparticles, enhancing the moisturizing, antioxidant, regenerating and photoprotective activity of the skin. Suitable safety/shelf-life stability of these novel formulations is key to a successful translation to the clinic/industry.

Promising Functions of Novel Vitamin D Derivatives as Cosmetics: A New Fountain of Youth in Skin Aging and Skin Protection

“…Compared to different anti-aging strategies, such as botox and fillers, vitamin D can be delivered into the skin topically [280,281]. Topical application, including transdermal delivery [282], is effective, safe and pain-free [283,284].…”

Ethosomes for Curcumin and Piperine Cutaneous Delivery to Prevent Environmental-Stressor-Induced Skin Damage

“…In this respect, ETs can be thought of as transdermal delivery systems, being able to promote the permeability of entrapped drugs through different skin strata. The ET simple and low-energy-consuming production protocol, together with the biocompatibility of the excipients, make these systems particularly attractive for dermatological applications, as demonstrated by the increasingly growing number of related research articles [37][38][39].…”

Ex vivo Evaluation of a Liposome-Mediated Antioxidant Delivery System on Markers of Skin Photoaging and Skin Penetration

“…Emerging approaches to modulate the delivery of antioxidants to the skin have utilized specialized delivery carriers such as nanoparticles or liposomes. 21 , 22 In these strategies, antioxidants are encapsulated in a variety of different vesicular, lipidic, and polymeric systems to prevent degradation and improve penetration. 22 For molecules to pass through the stratum corneum, there are physiochemical properties that must be met.…”

“… 21 , 22 In these strategies, antioxidants are encapsulated in a variety of different vesicular, lipidic, and polymeric systems to prevent degradation and improve penetration. 22 For molecules to pass through the stratum corneum, there are physiochemical properties that must be met. For example, the partition coefficient (log P) must be high enough for the molecule to pass through the lipid-rich stratum corneum.…”

“…Preliminary studies have shown that various drug delivery systems may enhance the bioavailability and delivery of these antioxidants. 22 Thus, the objective of this ex-vivo study was to assess the effects of a topical liposome-mediated drug delivery system with antioxidants (XOSM™ technology, Image Skincare, Lantana, FL, USA) versus free antioxidants alone on parameters of skin photoaging in human skin explants. Additionally, this study aims to test the penetrability of the liposome-mediated drug delivery system.…”