Novel nanotechnology-based approaches in the treatment of leishmaniasis

Dasauni, Khushboo; Bisht, Deepa; Nailwal, Tapan Kumar

doi:10.1016/b978-0-12-822800-5.00005-6

Cited by 3 publications

(2 citation statements)

References 60 publications

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“…Successful transmission of Leishmania parasites to humans is exclusively connected with the bloodsucking behavior of female phlebotomine sand flies 1,2 . Depending on host and parasitic factors, leishmaniasis is manifested in three clinical forms: visceral leishmaniasis (VL), mucocutaneous leishmaniasis and cutaneous leishmaniasis (CL) 1,3 …”

Section: Introductionmentioning

confidence: 99%

The Quest for Understanding Cutaneous Leishmaniasis in Northern Province, Sri Lanka: An Analysis of Clinical Data From the District General Hospital, Vavuniya

Arulenthiran,

Murugananthan,

Amarasinghe

et al. 2023

Infect Microb Dis

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The study aimed to examine the clinical and epidemiological patterns of cutaneous leishmaniasis (CL) in patients attending the Dermatology Unit, District General Hospital in Vavuniya, Sri Lanka. A total of 77 patients clinically suspected for CL were interviewed through a structured questionnaire and skin-lesion samples were obtained between January 2016 and January 2017. The definitive diagnosis of CL was made through microscopic identification of smears, histopathological examination of biopsies and kDNA PCR. Treatment modalities were chosen based on the location of the lesions on the body and complexity of the lesions. Of 77 suspected patients, 68 were confirmed for CL, with a mean age of 34.6 (±12.7) years, and included 54 males (79.4%) and 14 females (20.6%). Being a male was a significant risk factor (P = 0.032, OR = 4.82) associated with CL. Lesions were observed mainly on the exposed areas of the body, of which the forearm (22.1%) was the most commonly affected site. Single lesions (75.0%) and ulcerated nodules with central crust (39.7%) were the prominent features among the infected group. The age-group of 21-40 years was significantly associated with healing lesions (P = 0.028, ME = 0.55). However, a significant negative relationship was detected between ulcerated nodular lesions and lesion healing (P = 0.0436, ME = -0.375). Males are at higher risk of CL. Early diagnosis and specific treatment, along with preventive measures such as protective clothing and sand fly repellents can limit the spread of the disease. There is a need for a comprehensive approach to prevent and control the transmission of CL.

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Section: Introductionmentioning

confidence: 99%

The Quest for Understanding Cutaneous Leishmaniasis in Northern Province, Sri Lanka: An Analysis of Clinical Data From the District General Hospital, Vavuniya

Arulenthiran,

Murugananthan,

Amarasinghe

et al. 2023

Infect Microb Dis

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“…SLNs have been shown as a potent means for achieving targeted, sustained release for various APIs, including chemotherapeutics [3], genetic material [4], and anti-rheumatics [5]. Since their first conception in 1996 [6], the technology has developed to allow for a wider scope of APIs to be internalised, as well as improving particle characteristics such as stability, targeting, and size [4,7]. The structure of an SLN can allow for the encapsulation of both hydrophilic and hydrophobic molecules, due to the hydrophobic core and hydrophilic external layer (Fig.…”

Section: Introductionmentioning

confidence: 99%

Microfluidic encapsulation of enzymes and steroids within solid lipid nanoparticles

Weaver

Sommonte

Hooker

et al. 2023

Drug Deliv. and Transl. Res.

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The production of solid lipid nanoparticles (SLNs) is challenging, especially when considering the incorporation of biologics. A novel in-house method of microfluidic production of biologic-encapsulated SLNs is proposed, using a variety of base materials for formulation to help overcome the barriers presented during manufacture and administration. Trypsin is used as a model drug for hydrophilic encapsulation whilst testosterone is employed as a positive non-biologic lipophilic control active pharmaceutical ingredient. Particle sizes obtained ranged from 160 to 320 nm, and a lead formulation has been identified from the combinations assayed, allowing for high encapsulation efficiencies (47–90%, respectively) of both the large hydrophilic and the small hydrophobic active pharmaceutical ingredients (APIs). Drug release profiles were analysed in vitro to provide useful insight into sustained kinetics, providing data towards future in vivo studies, which displayed a slow prolonged release for testosterone and a quicker burst release for trypsin. The study represents a large leap forward in the field of SLN production, especially in the field of difficult-to-encapsulate molecules, and the technique also benefits from being more environmentally sustainable due to the use of microfluidics. Graphical Abstract

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Rational computational approaches to predict novel drug candidates against leishmaniasis

Bustamante

Muskus

Ochoa

2022

Virtual Screening and Drug Docking

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Novel nanotechnology-based approaches in the treatment of leishmaniasis

Cited by 3 publications

References 60 publications

The Quest for Understanding Cutaneous Leishmaniasis in Northern Province, Sri Lanka: An Analysis of Clinical Data From the District General Hospital, Vavuniya

The Quest for Understanding Cutaneous Leishmaniasis in Northern Province, Sri Lanka: An Analysis of Clinical Data From the District General Hospital, Vavuniya

Microfluidic encapsulation of enzymes and steroids within solid lipid nanoparticles

Rational computational approaches to predict novel drug candidates against leishmaniasis

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