Novel nanozyme-catalyzed and magnetically assisted colorimetric biosensor for Staphylococcus aureus detection with a low matrix effect from complex environments

Zhu, Shuangju; Zhang, Wu; Niu, Xiaojuan; Zhan, Xiangqiang; Han, Tao; Wu, Yuangen

doi:10.1016/j.snb.2022.132752

Cited by 23 publications

(7 citation statements)

References 35 publications

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“…In contrast, physical adsorption of ssDNA can also reduce the activity of some nanozymes. 38,40,[60][61][62][63][64][65][66][67][86][87][88][89][90][91][92][93][94][95][96][97][98][99][100][101][102][103] It is generally considered that the adsorption of DNA chains (aptamers) covers some surfaces of nanomaterials, and the shielding of active sites causes the decrease in their enzyme-like catalytic activity. At the very beginning, Bansal's group observed that AuNPs exhibited the PODlike activity originating from the interaction of their surface with the POD substrate TMB.…”

Section: Dna Configurationmentioning

confidence: 99%

“…Currently, the interactions between DNA chains (aptamers) and nanozymes have been applied to establish biosensors for the monitoring of various health risk factors, including antibiotics, 59,62,65,76,84,91 toxins, 56,69,80,100,103,131,132 pesticide residues, 90,97 and pathogens and viruses. 51,63,66,[93][94][95]133 The emergence and application of antibiotics is a major revolution in the history of human medicine. However, with the widespread use of antibiotics, including medical antibiotics and antibiotics for animals, new problems that seriously threaten human health have soon emerged.…”

Section: Monitoring Of Health Risk Factorsmentioning

confidence: 99%

“…For the monitoring of pathogens and viruses, several studies have realized this purpose by fabricating aptamerinvolved nanozyme-based sensors. 51,63,66,[93][94][95]133 Among these, Bansal's group established a colorimetric and electrochemical dual-signal aptasensor for Pseudomonas aeruginosa. 63 In comparison with immunosensing, fluorescence hybridization-based detection, and quantitative PCR, the method possessed better results within a short time (10 min) and could be used for rapid, on-site analysis.…”

Section: F I G U R E 1 1 (A)mentioning

confidence: 99%

“…In contrast, physical adsorption of ssDNA can also reduce the activity of some nanozymes 38,40,60–67,86–103 . It is generally considered that the adsorption of DNA chains (aptamers) covers some surfaces of nanomaterials, and the shielding of active sites causes the decrease in their enzyme‐like catalytic activity.…”

Section: Modulation Of Nanozyme Activity By Dnamentioning

confidence: 99%

“…Identifying these risks and taking corresponding preventive measures is a major demand for protecting human health. Currently, the interactions between DNA chains (aptamers) and nanozymes have been applied to establish biosensors for the monitoring of various health risk factors, including antibiotics, 59,62,65,76,84,91 toxins, 56,69,80,100,103,131,132 pesticide residues, 90,97 and pathogens and viruses 51,63,66,93–95,133 …”

Section: Biosensing Applicationsmentioning

confidence: 99%

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When nanozymes meet deoxyribonucleic acid: Understanding their interactions and biomedical diagnosis applications

Liang,

Chen,

et al. 2024

Interdisciplinary Medicine

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As emerging alternatives to natural enzymes, nanoscale materials featuring enzyme‐like catalytic behaviors (nanozymes) exhibit some attractive merits including robust activity, low cost, and easy‐to‐regulate performance. These merits have enabled them to be intensively used in the biomedical field in recent years. To remedy the lack of catalytic selectivity in most nanozymes, deoxyribonucleic acid (DNA) chains with specific recognition functions are utilized to integrate with nanozymes to produce various nanozyme–DNA combinations via adsorption/desorption. In the formed combinations, the DNA component provides the molecular/ionic recognition role, and the nanozyme part offers response with catalytically amplified signals, enabling them to detect analytes and biomarkers selectively and sensitively. To highlight this interesting topic, here we made a critical review of the interactions between nanozymes and DNA and their applications in biosensing and disease diagnosis. First, strategies for the conjugation of DNA chains onto nanozyme surface were introduced briefly. Then, the interactions between DNA and nanozymes were summarized in detail, where flexible modulations of nanozyme activity by DNA adsorption/desorption as well as various factors were analyzed, and potential impacts caused by nanozymes on the recognition characteristics of DNA chains were pointed out. After that, typical applications of DNA‐mediated nanozyme modulation in toxic ion sensing, health risk factor monitoring, and biomedical diagnosis were introduced. In the end, prospects of the combination of nanozymes and DNA chains were presented, and future challenges of the emerging field were also discussed, to attract more interest and effort to advance this promising area.

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