Novel neurolisteriosis therapy using SPION as a drivable nanocarrier in gallic acid delivery to CNS

Azarmi, Mehrdad; Maleki, Hadi; Nikkam, Nader; Malekinejad, Hassan

doi:10.1016/j.jconrel.2022.12.006

Cited by 8 publications

(2 citation statements)

References 45 publications

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“…Therefore, these properties of GA pose challenges in achieving sustained therapeutic levels of the compound in pharmaceutical approaches. To overcome these limitations, several procedures, including drug delivery systems such as niosomes [12,15,[20][21][22], have been proposed to encapsulate GA, protecting it from degradation and facilitating its targeted delivery to specific sites in the body [23][24][25].…”

Section: Introductionmentioning

confidence: 99%

Span 60/Cholesterol Niosomal Formulation as a Suitable Vehicle for Gallic Acid Delivery with Potent In Vitro Antibacterial, Antimelanoma, and Anti-Tyrosinase Activity

Zolghadri,

Asad,

Farzi

et al. 2023

Pharmaceuticals

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Natural compounds such as gallic acid (GA) have attracted more attention in cosmetic and pharmaceutical skin care products. However, the low solubility and poor stability of GA have limited its application. This study aimed to synthesize and characterize the GA niosomal dispersion (GAN) and investigate the potential of an optimal formulation as a skin drug delivery system for GA. For this purpose, GAN formulations were synthesized using the thin layer evaporation method with different molar ratios of Tween 60/Span 60, along with a constant molar ratio of polyethylene glycol 4000 (PEG-4000) and cholesterol in a methanol and chloroform solvent (1:4 v/v). The physicochemical properties of nanosystems in terms of size, zeta potential, drug entrapment, drug release, morphology, and system–drug interaction were characterized using different methods. In addition, in vitro cytotoxicity, anti-tyrosinase activity, and antibacterial activity were evaluated by MTT assay, the spectrophotometric method, and micro-well dilution assay. All formulations revealed a size of 80–276 nm, polydispersity index (PDI) values below 0.35, and zeta potential values below—9.7 mV. F2 was selected as the optimal formulation due to its smaller size and high stability. The optimal formulation of GAN (F2) was as follows: a 1:1 molar ratio of Span 60 to cholesterol and 1.5 mM GA. The release of the F2 drug showed a biphasic pattern, which was fast in the first 12 h until 58% was released. Our results showed the high antibacterial activity of GAN against Escherichia coli and Pseudomonas aeruginosa. The MTT assay showed that GA encapsulation increased its effect on B6F10 cancer cells. The F2 formulation exhibited potent anti-tyrosinase activity and inhibited melanin synthesis. These findings suggest that it can be used in dermatological skin care products in the cosmetic and pharmaceutical industries due to its significant antibacterial, anti-melanoma, and anti-tyrosinase activity.

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Section: Introductionmentioning

confidence: 99%

Span 60/Cholesterol Niosomal Formulation as a Suitable Vehicle for Gallic Acid Delivery with Potent In Vitro Antibacterial, Antimelanoma, and Anti-Tyrosinase Activity

Zolghadri,

Asad,

Farzi

et al. 2023

Pharmaceuticals

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“…Moreover, SPION is an attractive drug delivery system due to its biocompatibility, chemical stability, and inherent multifunctionality [7,8]. The versatility of SPION leads to their utilization in a wide range of biomedical applications, including magnetic resonance imaging (MRI) as a contrast agent [9], drug delivery [10], magnetic hyperthermia treatment (MHT) [11] and biosensing [12]. However, the direct application of SPION is limited by its tendency to agglomerate in biological fluids and subsequent removal by the cells of reticuloendothelial system (RES) [8,13].…”

Section: Introductionmentioning

confidence: 99%

Magnetic-Guided Targeted Delivery of Zerumbone/Spion Co-Loaded in Nanostructured Lipid Carrier into Breast Cancer Cells

Tan

How

Low

et al. 2023

Preprint

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Development and characterization of lipid nanocapsules loaded with iron oxide nanoparticles for magnetic targeting to the blood–brain barrier

Aparicio-Blanco,

Pucci,

De Pasquale

et al. 2024

Drug Deliv. and Transl. Res.

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Brain drug delivery is severely hindered by the presence of the blood–brain barrier (BBB). Its functionality relies on the interactions of the brain endothelial cells with additional cellular constituents, including pericytes, astrocytes, neurons, or microglia. To boost brain drug delivery, nanomedicines have been designed to exploit distinct delivery strategies, including magnetically driven nanocarriers as a form of external physical targeting to the BBB. Herein, a lipid-based magnetic nanocarrier prepared by a low-energy method is first described. Magnetic nanocapsules with a hydrodynamic diameter of 256.7 ± 8.5 nm (polydispersity index: 0.089 ± 0.034) and a ξ-potential of -30.4 ± 0.3 mV were obtained. Transmission electron microscopy-energy dispersive X-ray spectroscopy analysis revealed efficient encapsulation of iron oxide nanoparticles within the oily core of the nanocapsules. Both thermogravimetric analysis and phenanthroline-based colorimetric assay showed that the iron oxide percentage in the final formulation was 12 wt.%, in agreement with vibrating sample magnetometry analysis, as the specific saturation magnetization of the magnetic nanocapsules was 12% that of the bare iron oxide nanoparticles. Magnetic nanocapsules were non-toxic in the range of 50–300 μg/mL over 72 h against both the human cerebral endothelial hCMEC/D3 and Human Brain Vascular Pericytes cell lines. Interestingly, higher uptake of magnetic nanocapsules in both cell types was evidenced in the presence of an external magnetic field than in the absence of it after 24 h. This increase in nanocapsules uptake was also evidenced in pericytes after only 3 h. Altogether, these results highlight the potential for magnetic targeting to the BBB of our formulation. Graphical Abstract

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Novel neurolisteriosis therapy using SPION as a drivable nanocarrier in gallic acid delivery to CNS

Cited by 8 publications

References 45 publications

Span 60/Cholesterol Niosomal Formulation as a Suitable Vehicle for Gallic Acid Delivery with Potent In Vitro Antibacterial, Antimelanoma, and Anti-Tyrosinase Activity

Span 60/Cholesterol Niosomal Formulation as a Suitable Vehicle for Gallic Acid Delivery with Potent In Vitro Antibacterial, Antimelanoma, and Anti-Tyrosinase Activity

Magnetic-Guided Targeted Delivery of Zerumbone/Spion Co-Loaded in Nanostructured Lipid Carrier into Breast Cancer Cells

Development and characterization of lipid nanocapsules loaded with iron oxide nanoparticles for magnetic targeting to the blood–brain barrier

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