Novel neurotrophic phenylbutenoids from Indonesian ginger Bangle, Zingiber purpureum

Kubo, Miwa; Gima, Minori; Baba, Kohei; Nakai, Megumi; Harada, Kenichi; Suenaga, Masaya; Matsunaga, Yoichi; Kato, Eishin; Hosoda, Shinya

doi:10.1016/j.bmcl.2015.02.005

Cited by 26 publications

(25 citation statements)

References 20 publications

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“…Given that 10 ng/mL of Bangle extract was the most effective concentration for the promotion of hfNSC differentiation, we used it in all subsequent assays. We then investigated the effect of cis and trans isomers of Banglene, the reported active compounds of Bangle [ 20 ], on neuronal differentiation of hfNSCs and found that both isoforms also increased the percentage of βIII-tubulin- ( Figure 1 B), DCX- and CTIP2-positive cells, while reducing that of SOX2-positive cells ( Figure S2 ). Together, these results indicate that both Bangle extract and cis/trans -Banglene have the ability to promote neuronal differentiation of hfNSCs.…”

Section: Resultsmentioning

confidence: 99%

Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation

Hirano

Kubo

Namihira

2020

IJMS

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Indonesian ginger (Zingiber purpureum Rosc.), also known as Bangle, exhibits neurotrophic effects on cultured murine cortical neurons and in the adult mouse brain, but the underlying mechanisms remain unknown. Here, using human fetal neural stem cells (hfNSCs) as a model system for in vitro human neurogenesis, we show that Bangle extracts activate canonical WNT/β-catenin signaling. Bangle extract-treatment of hfNSCs not only promoted neuronal differentiation, but also accelerated neurite outgrowth from immature neurons. Furthermore, Bangle extracts induced expression of neurogenic genes and WNT signaling-target genes, and facilitated the accumulation of β-catenin in nuclei of hfNSC. Interestingly, altered histone modifications were also observed in Bangle-treated hfNSCs. Together, these findings demonstrate that Bangle contributes to hfNSC neurogenesis by WNT pathway and epigenetic regulation.

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Section: Resultsmentioning

confidence: 99%

Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation

Hirano

Kubo

Namihira

2020

IJMS

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“…Compounds 1 and 2 were found not only to significantly induce neurite sprouting of PC12 cells, but also to increase the neurite length and number of neuritis, and to show protective activity against cell death caused by deprivation of serum in primary cultured rat cortical neurons [2]. Additionally, we found a new curcuminoid-type compound with effect on accelerating the prevention of Aβ42 aggregation [3]. As in vivo studies, it was found that chronic treatments with 1 and 2 were able to enhance hippocampal neurogenesis in dementia model OBX mice [2].…”

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confidence: 78%

Studies on Extraction Conditions to Increase the Content of Neurotrophic Compounds in the Bangle (Zingiber purpureum) Extract

Kubo

Kaga

Harada³

et al. 2017

Natural Product Communications

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To develop the Javanese ginger Bangle (Zingiber purpureum), which contains neurotrophic phenylbutenoid compounds named banglenes 1 and 2, as a functional food additive for protection of neurodegenerative disease, we investigated conversion method from 3 to 1 and 2 under practical conditions available in food processing steps. After several trials, we found that dimerization of 3 proceeded smoothly under refluxing EtOH/H 2 O (1/3) in the presence of ubiquinone (0.1 eq) in sealed tube, giving rise to 1 and 2 in 54% yield. When this condition was applied for 70% EtOH extract of bangle, content of 1 and 2 in the extract was increased 2-fold by 2.1%.

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“…Several types of compounds in Z. cassumunar have been identified such as phenylbutenoids, curcuminoids, sesquiterpenoids, benzaldehydes, quinones, and essential oils containing monoterpenoids. Phenylbutenoids are characteristic compounds of this plant and have been isolated using various isolation technics [2][3][4][5][6][7][8][9][10][11][12][13][14], including silica gel or reverse phase column chromatography [2][3][4][5][6][7][8][9][10], recrystallization [3,4], preparative thin-layer chromatography [6], countercurrent chromatography [11,12], and preparative high-performance liquid chromatography [10,13,14]. Other constituents include curcuminoids, including a high content of curcumin as a yellow pigment in the rhizome [13][14][15][16][17], two quinones [3,4,18], phenolic compounds [13,17], and sesquiterpenoids such as (−)-β-sesquiphellandrene and zerumbone [12,[19][20][21].…”

Section: Introductionmentioning

confidence: 99%

Phytochemicals and Bioactivities of Zingiber cassumunar Roxb

et al. 2021

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Zingiber cassumunar Roxb. (Zingiberaceae), is an important medicinal plant known as “Plai (Phlai)” in Thailand, “Bangle” in Indonesia, and “Bulei” in China. Traditionally, this plant has been used to treat inflammation, pain, and respiratory problems. The rhizomes are the primary part of the plant that has been used for medicinal purposes due to their constituents with therapeutic properties, including phenylbutenoids, curcuminoids, and essential oils. Since the 1970s, many studies have been conducted on the phytochemicals and bioactivities of Z. cassumunar to establish fundamental scientific evidence that supports its use in traditional medicine. The accumulated biological studies on the extracts, solvent fractions, and constituents of Z. cassumunar have described their diverse medicinal properties, including antioxidant, anti-inflammatory, anticancer, neuroprotective/neurotrophic, cosmeceutical, and antifungal/antimicrobial bioactivities. In this review, we summarize information on the phytochemicals of Z. cassumunar and the bioactivities of its extracts and constituents.

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Novel neurotrophic phenylbutenoids from Indonesian ginger Bangle, Zingiber purpureum

Cited by 26 publications

References 20 publications

Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation

Indonesian Ginger (Bangle) Extract Promotes Neurogenesis of Human Neural Stem Cells through WNT Pathway Activation

Studies on Extraction Conditions to Increase the Content of Neurotrophic Compounds in the Bangle (Zingiber purpureum) Extract

Phytochemicals and Bioactivities of Zingiber cassumunar Roxb

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