The development of simple, accurate, responsive, and selective antimicrobial drug analysis platforms is extremely important for biomedical research. Developing a novel electrode material that possesses low detection limit, high sensitivity, and stability continues to be a difficult undertaking. Here, vanadium tungstate nanostones (VWNs) were synthesized by utilizing facile sonochemical method with the aid of urea and ethylene glycol for application in electrochemical sensing of antibiotic drug nitrofurantoin (NFT). Using a distinct analytical methods, the structural and morphological characteristics of the as‐prepared transducer material were described. Further, electrochemical behaviour of modified electrode were analysed using cyclic voltammetry and liner sweep voltammetry. Under the optimal conditions VWNs/GCE electrode exhibited superior electrocatalytic activity towards NFT with linear range (20–160 μM), limit of detection (0.019 μM) with better sensitivity (0.69 μM−1 cm−2). The modified electrode demonstrated remarkable repeatability, reproducibility, and excellent stability, indicating its potential as an electrocatalyst. Ultimately, the suggested electrode was used to measure FLT in real samples like tap water and NFT capsule.