In the random sea environment, offshore platforms are influenced by factors such as wind, waves, and currents, as well as their interactions, leading to complex motion phenomena that affect the safety of offshore platform operations. Consequently, accurately predicting the motion response of offshore platforms has long been a key focus in the fields of naval architecture and ocean engineering. This paper utilizes STAR-CCM+ to simulate time-history data of offshore platform motion responses under both regular and irregular waves. Furthermore, a predictive model combining residual convolutional neural networks and long short-term memory neural networks using neural network technology is also studied. This model utilizes an autoregressive approach to predict the motion responses of offshore platforms, with its predictive accuracy validated through comprehensive evaluations. Under regular wave conditions, the coefficient of determination (R2) for the platform’s heave and pitch responses consistently exceeds 0.99. Meanwhile, under irregular wave conditions, the R2 values remain generally above 0.4. Additionally, the model exhibits commendable performance in terms of Mean Squared Error (MSE) and Mean Absolute Percentage Error (MAPE) metrics. The aim of this study is to present a novel approach to predicting offshore platform motion responses, while providing a more scientific basis for decision-making in offshore platform operations.