Novel of nano delivery system for Linalool loaded on gold nanoparticles conjugated with CALNN peptide for application in drug uptake and induction of cell death on breast cancer cell line

Jabir, Majid S.; Taha, Ali A.; Sahib, Usama I.; Taqi, Zainab J.; Al-Shammari, Ahmed Majeed; Salman, Alya Saeed

doi:10.1016/j.msec.2018.10.014

Cited by 89 publications

(54 citation statements)

References 41 publications

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“…AuNPs' desirable physicochemical properties comprise very small size, easy surface functionalization, as well as electrical and optical effects. Moreover, they allow surface functionalization based on several molecule types such as drugs, proteins and nucleic acids [13][14][15][16][17].…”

Section: Introductionmentioning

confidence: 99%

Anti-EGFR-Coated Gold Nanoparticles In Vitro Carry 5-Fluorouracil to Colorectal Cancer Cells

et al. 2020

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The aim of the current study is to present a strategy to improve the efficiency of 5-fluorouracil (5-FU), which is widely used as antineoplastic agent against solid tumors-based on the use of gold nanocarriers to overcome the resistance of colorectal cancer cells. 5-FU was loaded on gold nanoparticles (AuNP) coated with anti-EGFR antibodies in order to target them towards colorectal cancer cells that overexpress epidermal growth factor receptors (EGFR). Physicochemical characterization has shown that AuNP size was approximately 20 nm and that AuNP functionalization led to spherical nanoparticles. Flow cytometry allowed observing that some compounds synthesized by our research group have induced apoptosis/necrosis and impaired the proliferation of colon cancer cell lines ‘HCT-116′ and ‘HT-29′. The antibody/drug combination in AuNP (AuNP 5FU EGFR) has improved the apoptosis rate and impaired cell proliferation in both cell lines, regardless of the exposure time. Overall, these results have shown that AuNP functionalization with monoclonal antibodies focused on delivering 5-FU to tumor cells is an exciting strategy against colorectal cancer.

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Section: Introductionmentioning

confidence: 99%

Anti-EGFR-Coated Gold Nanoparticles In Vitro Carry 5-Fluorouracil to Colorectal Cancer Cells

et al. 2020

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“…Next, the cells were exposed to P. lanceolata leaf extract at different concentrations. The cells were then stained with crystal violet stain and examined under an inverted microscope [23].…”

Section: Clonogenic Assaymentioning

confidence: 99%

Selective cytotoxic effect of Plantago lanceolata L. against breast cancer cells

Alsaraf

Mohammad

Al-Shammari

et al. 2019

J Egypt Natl Canc Inst

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Background: Plantago lanceolata L. is used in Iraqi folklore medicine to treat injuries, and its extract is prescribed by some herbalists for cancer patients. This research aimed to evaluate the effect of P. lanceolata leaf extract on breast cancer cell lines in vitro and to identify its active compounds. Crystal violet viability assay was used to determine the cytotoxicity of methanolic P. lanceolata leaf extract against various breast cancer cell lines. MCF7, AMJ13, MDAMB, and CAL51 human breast cancer cells were treated with different concentrations of the extract for 72 h. The morphology of the treated cells was examined under a phase-contrast inverted microscope. The clonogenic ability was assessed through a clonogenic assay. High-performance liquid chromatography (HPLC) analysis was performed to measure the concentrations of phenols and flavonoids in the extract. Results: The methanolic P. lanceolata leaf extract significantly inhibited the proliferation of triple-negative CAL51 cells but showed minor effect on the other breast cancer cells. In addition, at high doses, it induced cytopathic morphological changes. The clonogenic assay showed low colony formation in the exposed cells, especially CAL51 cells. Furthermore, HPLC study revealed that the methanolic extract contained important flavonoid glycosides, especially rutin, myricetin quercetin, and kaempferol. Conclusions: P. lanceolata leaf extract selectively inhibited the proliferation of CAL51 triple-negative breast cancer cells and showed minor effect on the other breast cancer cells types studied. Thus, this study showed P. lanceolata as a possible natural source of selective anti-triple-negative breast cancer drugs.

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“…The aluminainteracted cells showed distorted cell morphology, indicating the distortion of bacterial cells [26]. Also, Murdock et al [27] observed that the behavior of alumina NPs was also influenced by particle size, shape and charge of surface. NPs tend to agglomerate in hard water and seawater because NPs interact with organic matters that are present in water; agglomeration of these nanoparticles is also influenced by the salinity and the pH of water.…”

Section: Wound Healing Activity By Al 2 O 3 Nanoparticlesmentioning

confidence: 99%

Preparation of Aluminum Oxide Nanoparticles by Laser Ablation and a Study of Their Applications as Antibacterial and Wounds Healing Agent

Jawad¹,

Saleh²,

Abd-Alhamza³

2019

Nano BioMed ENG

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Aluminum oxide nanoparticles were prepared and characterized with a wide variety of applications. This study aimed at the preparation of AlO 2 nanoparticles by the liquid particles treated with laser (1064 nm), immersed in deionized water at varied laser energy (350 J/cm 2 ) and diverse numbers of 300 pulse. For antimicrobial, antioxidants, animal's model, the prepared nanoparticles were confirmed by using ultraviolet-visible spectroscopy (UV-Vis), X-ray diffraction (XRD) and scanning electronic microscope (SEM). The antimicrobial activity of synthesized Al 2 O 3 nanoparticles was tested using well diffusion method against three types of bacteria: Escherichia coli, Pseudomonas aeruginosa and Staphylococcus aureus. The best concentration of aluminum oxide nanoparticles was 100 mg/mL, which exhibited a higher antibacterial activity against both gram-negative and -positive bacteria. In addition, the results showed that the gram-negative bacteria were more resistible than gram-positive bacteria. The results also indicated that the aluminum oxide nanoparticles possessed antioxidant effects, as investigated by DPPH method. Finally, the wound healing activity of the aluminum oxide nanoparticles was investigated, and the results showed that the aluminum oxide nanoparticles stimulated the wound healing activity by using animal's model. The results presented in this study demonstrated that the aluminum oxide nanoparticles had biomedical applications could be applied in biomedical uses in the future.

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Novel of nano delivery system for Linalool loaded on gold nanoparticles conjugated with CALNN peptide for application in drug uptake and induction of cell death on breast cancer cell line

Cited by 89 publications

References 41 publications

Anti-EGFR-Coated Gold Nanoparticles In Vitro Carry 5-Fluorouracil to Colorectal Cancer Cells

Anti-EGFR-Coated Gold Nanoparticles In Vitro Carry 5-Fluorouracil to Colorectal Cancer Cells

Selective cytotoxic effect of Plantago lanceolata L. against breast cancer cells

Preparation of Aluminum Oxide Nanoparticles by Laser Ablation and a Study of Their Applications as Antibacterial and Wounds Healing Agent

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