Novel one-pot Cu-nanoparticles-catalyzed Mannich reaction

An Eco-Friendly Protocol for Synthesis of β- aminoketones via Mannich Reaction Using Citric Acid: A Biodegradable Catalyst

“…β-amino carbonyl derivatives are found in a number of biologically active natural products [5]. The reported Mannich reactions have been catalyzed by various Lewis or Brønsted acid catalysts such as silica-supported AlCl 3 [6], CeCl 3 .7H 2 0 [7], NbCl 5 [8], BiCl 3 [9], CAN [10], HClO 4 -SiO 2 [11], Bi(OTf) 3 [12], Zn(OTf) 2 [13], ionic liquid [14][15][16][17], sulphamic acid [18][19][20], Fe(Cp) 2 PF 6 [21], Cu-nanoparticles [22], [RE(PFO) 3 ] [23], silica based tin(II) catalyst [24], PEG-SO 3 H [25] ZSM-5-SO 3 H [26], carbon based solid acid [27], polyaniline/SiO 2 [28], lipase [29], saccharose [30], heteroplyacid salts [31]. However, most of the reported methods for the Mannich reaction suffer from drawbacks such as long reaction times and harsh reaction conditions, toxicity, and difficulty in product separation, which limit its use in the synthesis of complex molecules.…”

Synthesis and Evaluation of 5-(6-Methoxynaphthalen-2-Yl)-1-Aryl-1-(4-(Trifluoromethyl)phenylamino)pentan-3-One as Potential Antidiabetic Agents

“…Among them Mannich reaction is the most popular in the preparation of β-amino ketones because of higher "atom economy" and its "green" nature. The Mannich reaction relies on two as well as three component system, but the preferable route is the use of a one-pot three component setup rather than a two-step method 25 . We adopted the one-pot protocol by first reacting aldehyde with amine to form Schiff base, followed by adding ketone to yield the title molecules.…”

CuI nanoparticles as a remarkable catalyst in the synthesis of benzo[b][1,5]diazepines: an eco-friendly approach

“…20 Among various nanoparticles, copper nanoparticles have extensively considered interests because of their unusual properties and potential applications in diverse fields. 21 Recently, copper nanoparticles were used as an active catalyst in many reactions including carbon-heteroatom coupling, 22,23 synthesis of phenols, anilines, and thiophenols, 24 Synthesis of 1,4-dihydropyridines, 25 alkyne-azide cycloadditions, 26 the Mannich reaction, 27 azaMichael reactions 28 and hydroxylation of phenol. 29 Recently, Shaabani et al have reported a novel and efficient method for the synthesis of some tetrahydro-2,4-dioxo-1H-benzo[b] [1,5]diazepine-3-yl-2-methylpropanamide derivatives.…”