Novel optical nanosensors for probing and imaging live cells

Kneipp, Janina; Kneipp, Harald; Wittig, Burghardt; Kneipp, Katrin

doi:10.1016/j.nano.2009.07.009

Cited by 270 publications

(199 citation statements)

References 71 publications

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“…Raman scattering is a phenomenon that results from the inelastic collision of photons with molecules where energy, which is either lost or gained, translates to a change in the frequency of the scattered photons. This unique shift of frequency depends on the characteristic energy of molecular vibrations constituting the signal, hence a Raman spectrum consisting of different signals from molecular vibrations forms a "vibrational fingerprint" of a molecule [36] . In SERS, these Raman signals are amplified several folds by nanostructures present in the vicinity of the molecules.…”

Section: Applications Of Aunps In Cancer Managementmentioning

confidence: 99%

“…Gold and silver have been shown to cause significant enhancement [37] and are thus the favoured nanostructures used as sensors [24] . By attaching a reporter to SERS sensors, targeted sensitive probing of molecules or structures within cells may be achieved [36] . Recent studies have demonstrated the potential use of AuNPs for in vivo targeted imaging of cancer using Raman spectroscopy.…”

Section: Applications Of Aunps In Cancer Managementmentioning

confidence: 99%

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Gold nanoparticles in cancer therapy

et al. 2011

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The rapid advancement of nanotechnology in recent years has fuelled a burgeoning interest in the field of nanoparticle research, in particular, its application in the medical arena. A constantly expanding knowledge based on a better understanding of the properties of gold nanoparticles (AuNPs) coupled with relentless experimentation means that the frontiers of nanotechnology are constantly being challenged. At present, there seems to be heightened interest in the application of AuNPs to the management of cancer, encompassing diagnosis, monitoring and treatment of the disease. These efforts are undertaken in the hope of revolutionizing current methods of treatment and treatment strategies for a multifactorial disease such as cancer. This review will focus on the current applications of AuNPs in cancer management.

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Section: Applications Of Aunps In Cancer Managementmentioning

confidence: 99%

Section: Applications Of Aunps In Cancer Managementmentioning

confidence: 99%

Gold nanoparticles in cancer therapy

et al. 2011

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“…This has led to a marked increase in interest in SERS as a diagnostic approach in biomedical research. Research areas include the preparation and discovery of new SERS substrates such as NPs, surface functionalization [56], imaging [57] and clinical translation [58]. An example of work in this area includes the use of SERS in detection of decreased Raman peaks in the saliva of lung cancer patients compared to those who did not have the disease; this was attributed to differences in levels of proteins and nucleic acids in saliva [59].…”

Section: Cancermentioning

confidence: 99%

Vibrational spectroscopy of biofluids for disease screening or diagnosis: translation from the laboratory to a clinical setting

Mitchell

Gajjar

Theophilou

et al. 2014

Journal of Biophotonics

143

108

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There remains a need for objective and cost‐effective approaches capable of diagnosing early‐stage disease in point‐of‐care clinical settings. Given an increasingly ageing population resulting in a rising prevalence of chronic diseases, the need for screening to facilitate the personalising of therapies to prevent or slow down pathology development will increase. Such a tool needs to be robust but simple enough to be implemented into clinical practice. There is interest in extracting biomarkers from biofluids (e.g., plasma or serum); techniques based on vibrational spectroscopy provide an option. Sample preparation is minimal, techniques involved are relatively low‐cost, and data frameworks are available. This review explores the evidence supporting the applicability of vibrational spectroscopy to generate spectral biomarkers of disease in biofluids. We extend the inter‐disciplinary nature of this approach to hypothesise a microfluidic platform that could allow such measurements. With an appropriate lightsource, such engineering could revolutionize screening in the 21st century. (© 2014 WILEY‐VCH Verlag GmbH & Co. KGaA, Weinheim)

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“…The use of Surface Enhanced Raman Scattering from gold nanoparticles and nanoaggregates to probe the environment of the subcellular compartments through which they are trafficked has been demonstrated [124,125]. This approach also demonstrated the use of molecular labelled nanoparticles as more specific probes of the local environment [126][127][128]. However, the uptake rates and mechanisms as well as the subsequent trafficking may be specific to the nanoparticle type, size and surface chemistry.…”

Section: The Kinetics Concept: Timescales Of Interaction Of Nanopartimentioning

confidence: 99%

The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design

et al. 2013

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Abstract:In biological media, nanoparticles acquire a coating of biomolecules (proteins, lipids, polysaccharides) from their surroundings, which reduces their surface energy and confers a biological identity to the particles. This adsorbed layer is the interface between the nanomaterial and living systems and therefore plays a significant role in determining the fate and behaviour of the nanoparticles. This review summarises the state of the art in terms of understanding the bio-nano interface and provides direction for potential future research and recommendations for future priorities and strategies to support the safe implementation of nanotechnologies. The central premise is that nanomaterials must be studied as biological entities under the appropriate exposure conditions and that this should be implemented in study design and reporting for nanosafety assessment. The implications of the bio-nano interface for nanomaterials fate and behaviour are described in light of four interlinked perspectives: the Coating concept; the Translocation concept; the Signalling concept, and the Kinetics concept. A key conclusion is that nanoparticles cannot be viewed as non-interacting species, but rather must be thought of, and studied as, biological entities, where their interaction with the environment is mediated by the proteins and other biomolecules that adsorb to them, and the key parameter to characterise then becomes the nature, composition and evolution of the bionano interface.

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Novel optical nanosensors for probing and imaging live cells

Cited by 270 publications

References 71 publications

Gold nanoparticles in cancer therapy

Gold nanoparticles in cancer therapy

Vibrational spectroscopy of biofluids for disease screening or diagnosis: translation from the laboratory to a clinical setting

The bio-nano-interface in predicting nanoparticle fate and behaviour in living organisms: towards grouping and categorising nanomaterials and ensuring nanosafety by design

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