Novel oral dosage regimen based on self-nanoemulsifying drug delivery systems for codelivery of phytochemicals – Curcumin and thymoquinone

Alwadei, Majed; Kazi, Mohsin; Alanazi, Fars K.

doi:10.1016/j.jsps.2019.05.008

Cited by 66 publications

(47 citation statements)

References 42 publications

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“…(b) The inclusion of BSO, which possess good self-emulsification properties as confirmed by the significantly (p < 0.05) lower droplet size of both formulations containing BSO (F3 and F6, Figure 3). Similar low droplet size results were reported with other SNEDDS systems containing BSO [46]. (c) The inclusion of the water soluble cosolvent TcP in the formulation.…”

Section: Discussionsupporting

confidence: 85%

“…The significant difference between CUR and PP release from the same adsorbent could be attributed to the strong physical bonds developed between A300 and CUR, which hindered drug release upon exposure to GI fluids. Similar results were observed with the adsorbents Syloid and NUS, and could be correlated with one or more the following factors: smaller pore size, longer pore channels and/or developed hydrogen bonding between the drug and adsorbent [46,[54][55][56].…”

Section: Discussionsupporting

confidence: 83%

“…Accurately, 1 mL of BSO was separately dissolved in 10 mL solvent within volumetric flasks, filtered and used for analysis. The amount of thymoquinone (THQ) present in the black seed oil was 20%-50%, which matches with the reported standard THQ amount in BSO [46,57].…”

Section: Bso Standardizationsupporting

confidence: 82%

“…(5) The inclusion of Cr-RH40 that possesses superior self-emulsification properties as revealed by a previous study that compared the performance of Cr-RH40 and HCO-40 by fixing the oil, cosurfactant and cosolvent and only varying the surfactant type within the formulation. The study revealed that Cr-RH40-based SNEDDS showed excellent (>80%) drug release and lower droplet size compared to HCO-40 counterparts [46]. These findings were correlated with the higher HLB value of Cr-RH40 (HLB = 14-16) compared to HCO-40 (HLB = 12.5).…”

Section: Discussionmentioning

confidence: 81%

“…In order to obtain an optimum SNEDDS formula, six formulations were screened against their droplet size, zeta potential and equilibrium drug solubility parameters [13]. CUR and PP are poorly-water soluble drugs with partition coefficient values; logp ≈ 3 and 2.25, respectively [17,46]. The intermediate logp values reveal the expected affinity of the two drugs towards cosolvents and polar oils, which was confirmed by the high CUR and PP solubility in (F6, LFCS Type IIIB systems) ( Table 2).…”

Section: Discussionmentioning

confidence: 99%

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Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

et al. 2020

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Background: Bioactive oils of natural origin have gained huge interests from health care professionals and patients. Objective: To design a bioactive self-nanoemulsifying drug delivery system (Bio-SNEDDS) comprising curcumin (CUR) and piperine (PP) by incorporating bioactive natural oils in the formulation. Methods: The self-emulsifying properties of apricot, avocado, black seed and Zanthoxylum rhetsa seed oils were screened within various SNEDDS formulations. Each liquid SNEDDS formulation was loaded with both CUR and PP. The optimal liquid SNEDDS were solidified using Aeroperl® and Neusilin® at 1:1 w/w ratio. Liquid and solid SNEDDS were characterized by droplet size analysis, equilibrium solubility, scanning electron microscopy, X-ray powder diffraction, differential scanning calorimetry, and Fourier transform infrared spectroscopy. In-vitro dissolution studies were performed to evaluate the efficiency of CUR and PP release from solid Bio-SNEDDS. Results: The liquid SNEDDS comprised of black seed oil exhibited excellent self-emulsification performance, low droplet size along with transparent appearance. The inclusion of the cosolvent Transcutol P improved the solubilization capacity of both CUR and PP. The liquid SNEDDS were efficiently solidified using the two adsorbents and presented the drugs within amorphous state. In particular, SNEDDS comprised of black seed oil/Imwitor988/Transcutol P/Cremophor RH40 (20/20/10/50) and when solidified with Neusilin showed enhanced CUR and PP release (up to 60% and 77%, respectively). In addition, this formulation efficiently delivers the highly bioactive black seed oil to the patient. Conclusions: The optimized Bio-SNEDDS comprising black seed oil showed outstanding self-emulsification characteristics along with enhanced CUR/PP dissolution upon solidification.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 83%

Section: Bso Standardizationsupporting

confidence: 82%

Section: Discussionmentioning

confidence: 81%

Section: Discussionmentioning

confidence: 99%

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Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

et al. 2020

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Encapsulation of Bioactive Compound and Its Therapeutic Potential

Pachuau

Laldinchhana²,

Roy³

et al. 2020

Advanced Structured Materials

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Formulation and Development of Curcumin–Piperine-Loaded S-SNEDDS for the Treatment of Alzheimer’s Disease

Ahmad

Hafeez

2022

Mol Neurobiol

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Background and Objective:Curcumin (Cur) and piperine (Pip) are very well-known phytochemicals that claimed to have many health bene ts and have been widely used in foods and traditional medicines. This study investigated the therapeutic e cacy of these compounds to treat Alzheimer's disease (AD). However, poor oral bioavailability and permeability of curcumin are a major challenge for formulation scientists. In this research study, the researcher tried to enhance the bioavailability & permeability of curcumin by a nanotechnological approach. Materials and MethodsIn this research study, we developed a Cur-Pip-loaded SNEDDS in various oils. Optimized formulation NF3 was subjected to evaluate its therapeutic effectiveness on AD animal model in comparison with untreated AD model and treated group (by market formulation donepezil). ResultsOn the basis of characterization results it is con rmed that NF3 formulation is the best formulation. The optimized formulation shows a signi cant dose-dependent manner therapeutic effect on AD-induced model ConclusionNovel formulation Cur-Pip Solid-SNEDDS was successfully developed and optimized. It's expected developed S-SNEDDS can be a potential, safe and effective carrier for the oral delivery of curcumin to the brain. This research article rst reported the bio-active S-SNEDDS of Cur-Pip effect on Alzheimer's.

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Novel oral dosage regimen based on self-nanoemulsifying drug delivery systems for codelivery of phytochemicals – Curcumin and thymoquinone

Cited by 66 publications

References 42 publications

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

Bioactive Self-Nanoemulsifying Drug Delivery Systems (Bio-SNEDDS) for Combined Oral Delivery of Curcumin and Piperine

Encapsulation of Bioactive Compound and Its Therapeutic Potential

Formulation and Development of Curcumin–Piperine-Loaded S-SNEDDS for the Treatment of Alzheimer’s Disease

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