Novel oral edaravone attenuates diastolic dysfunction of diabetic cardiomyopathy by activating the Nrf2 signaling pathway

Wang, Ling; Zeng, Yaqiong; Gu, Juan-Hua; Song, Rui; Cang, Peng-Hui; Xu, Yongxuan; Shao, Xiaorong; Liao, Pu; Hy, Luo; Zhou, Xin‐Fu

doi:10.1016/j.ejphar.2022.174846

Cited by 8 publications

(3 citation statements)

References 70 publications

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“…(Table 1: Classification, sources, and functional properties of bioactive substances). As a safe and natural food additive with many sources and at low cost, active substances have a positive impact on a variety of diseases, such as diabetes [65,66], cancer [67], autoimmune diseases [68], cardiovascular diseases [69], and neurodegenerative diseases [70]. Curcumin is a polyphenolic substance extracted from the rhizomes of plants, such as ginger and araceae, and is a rare diketone compound in the plant kingdom [71].…”

Section: Origin Classification and Functional Properties Of Bioactive...mentioning

confidence: 99%

Research Progress of Protein-Based Bioactive Substance Nanoparticles

Han

Liu

et al. 2023

Foods

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Bioactive substances exhibit various physiological activities—such as antimicrobial, antioxidant, and anticancer activities—and have great potential for application in food, pharmaceuticals, and nutraceuticals. However, the low solubility, chemical instability, and low bioavailability of bioactive substances limit their application in the food industry. Using nanotechnology to prepare protein nanoparticles to encapsulate and deliver active substances is a promising approach due to the abundance, biocompatibility, and biodegradability of proteins. Common protein-based nanocarriers include nano-emulsions, nano-gels, nanoparticles, and nano complexes. In this review, we give an overview of protein-based nanoparticle fabrication methods, highlighting their pros and cons. Additionally, we discuss the applications and current issues regarding the utilization of protein-based nanoparticles in the food industry. Finally, we provide perspectives on future development directions, with a focus on classifying bioactive substances and their functional properties.

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Section: Origin Classification and Functional Properties Of Bioactive...mentioning

confidence: 99%

Research Progress of Protein-Based Bioactive Substance Nanoparticles

Han

Liu

et al. 2023

Foods

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“…(53) Following these reports, several clinical studies on the adminis-Table 1. Diseases involving reactive oxygen species and free radicals Brain/neurological disorders cerebral infarction, (4) diabetic neuropathy, (7) Alzheimer's disease/dementia, (8)(9)(10)(11) Parkinson's disease (12,13) Respiratory diseases pneumonia/infections, (14) smoking, (15) bronchial asthma, (16) chronic obstructive pulmonary disease (17) Cardiovascular diseases myocardial infarction, (18) arteriosclerosis, (19) ischemia-reperfusion injury, (18) heart failure, (20) cardiomyopathy (21) Gastrointestinal disorders gastric ulcer, (22) non-alcoholic steatohepatitis, (3) inflammatory bowel disease/ulcerative colitis (23) Endocrine disorders diabetes, (24) hyperlipidemia (25) Urologic diseases chronic nephritis, diabetic nephropathy, (26) nephrotic syndrome (27) Ophthalmic disorders cataract, (28) glaucoma, (29) age-related macular degeneration, (30) diabetic retinopathy, (24) retinopathy of prematurity, (31) dry eye (32) Other diseases cancer, (33) atopic dermatitis, (34) sunlight dermatitis, (35) chronic granulomatosis, (36) rheumatoid arthritis, (37) systemic lupus erythematosus, (37) chronic fatigue syndrome, (38) aging, (39) stains/wrinkles…”

Section: Disease Treatment By Suppressing Oxidative Stress By Antioxi...mentioning

confidence: 99%

Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment

Shichiri

Suzuki

Isegawa

et al. 2023

J. Clin. Biochem. Nutr.

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Although many diseases in which reactive oxygen species (ROS) and free radicals are involved in their pathogenesis are known, and antioxidants that effectively capture ROS have been identified and developed, there are only a few diseases for which antioxidants have been used for treatment. Here, we discuss on the following four concepts regarding the development of applications for disease treatment by regulating ROS, free radicals, and lipid oxidation with the findings of our research and previous reports. Concept 1) Utilization of antioxidants for disease treatment. In particular, the importance of the timing of starting antioxidant will be discussed. Concept 2) Therapeutic strategies using ROS and free radicals. Methods of inducing ferroptosis, which has been advocated as an iron-dependent cell death, are mentioned. Concept 3) Treatment with drugs that inhibit the synthesis of lipid mediators. In addition to the reduction of inflammatory lipid mediators by inhibiting cyclooxygenase and leukotriene synthesis, we will introduce the possibility of disease treatment with lipoxygenase inhibitors. Concept 4) Disease treatment by inducing the production of useful lipid mediators for disease control. We describe the treatment of inflammatory diseases utilizing pro-resolving mediators and propose potential compounds that activate lipoxygenase to produce these beneficial mediators.

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“… Sun et al, 2020 ; X. Wang et al, 2022 ) and intermittent hypoxia-induced cardiomyopathy in mice ( Zhou et al, 2018 ). Moreover, SFN also prevents age-associated cardiac and muscular dysfunction through activation of Nrf2 ( Angulo et al, 2019 ; Bose et al, 2020 ).…”

Section: Protective Effects Of Natural Products On Cvdsmentioning

confidence: 99%

Activation of Nrf2 signaling: A key molecular mechanism of protection against cardiovascular diseases by natural products

Wei

Yang

et al. 2022

Front. Pharmacol.

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Cardiovascular diseases (CVD) are a group of cardiac and vascular disorders including myocardial ischemia, congenital heart disease, heart failure, hypertension, atherosclerosis, peripheral artery disease, rheumatic heart disease, and cardiomyopathies. Despite considerable progress in prophylaxis and treatment options, CVDs remain a leading cause of morbidity and mortality and impose an extremely high socioeconomic burden. Oxidative stress (OS) caused by disequilibrium in the generation of reactive oxygen species plays a crucial role in the pathophysiology of CVDs. Nuclear erythroid 2-related factor 2 (Nrf2), a transcription factor of endogenous antioxidant defense systems against OS, is considered an ideal therapeutic target for management of CVDs. Increasingly, natural products have emerged as a potential source of Nrf2 activators with cardioprotective properties and may therefore provide a novel therapeutic tool for CVD. Here, we present an updated comprehensive summary of naturally occurring products with cardioprotective properties that exert their effects by suppression of OS through activation of Nrf2 signaling, with the aim of providing useful insights for the development of therapeutic strategies exploiting natural products.

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Novel oral edaravone attenuates diastolic dysfunction of diabetic cardiomyopathy by activating the Nrf2 signaling pathway

Cited by 8 publications

References 70 publications

Research Progress of Protein-Based Bioactive Substance Nanoparticles

Research Progress of Protein-Based Bioactive Substance Nanoparticles

Application of regulation of reactive oxygen species and lipid peroxidation to disease treatment

Activation of Nrf2 signaling: A key molecular mechanism of protection against cardiovascular diseases by natural products

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