Novel organic antibacterial thermal stabilizers for transparent poly(vinyl chloride)

Abstract

A novel kind of antibacterial thermal stabilizers for transparent poly(vinyl chloride), bis-uracil compounds with different alkyl chain length, was synthesized by the condensation of 6-amino-1,3-dimethyluracil with aliphatic aldehydes and characterized with 1 H NMR spectra. Not only high stabilization efficiency which increased with the increasing of alkyl chain length was obtained to prevent PVC from degradation, special antibacterial properties could also be acquired in the mean time of keeping PVC highly transparent. The results of discoloration test, thermogravimetric analysis, Fourier transform infrared spectra, visible spectroscopy and scanning electron microscopy revealed that the bis-uracil compounds could absorb HCl through acid-base reaction and chemical bonding, and the amine group played a key role in reacting with the inherent structural defects in PVC chains, meanwhile the long alkyl chain of the bis-uracil compounds could reduce their melting points and improve the compatibility with PVC. Comparing with the referential films stabilized by 6-amino-1,3-dimethyluracil and Ca/Zn stabilizers, PVC films stabilized with bis-uracil compounds had excellent transparency. In addition, the measurement of antimicrobial activity suggested that the bis-uracil compounds had the biological activity to inhibit growth of bacteria. We believe that PVC stabilized by such multifunctional stabilizers may widen its applications in biomedical field.

Development and Investigation of Lanthanum Sulfadiazine with Calcium Stearate and Epoxidised Soyabean Oil as Complex Thermal Stabilizers for Stabilizing Poly(vinyl chloride)

“…The mechanism of LaSD as a thermal stabilizer in PVC was studied through the following two experiments [21,22].…”

“…In recent years, a large number of studies have shown that the presence of uracil in compounds has a positive effect on improving the thermal stability of PVC [19,20,21,22]. Sabaa et al investigated uracil derivatives as PVC thermal stabilizers through a series of experiments and found that they can significantly improve the thermal stability of PVC [19,20].…”

“…Sabaa et al investigated uracil derivatives as PVC thermal stabilizers through a series of experiments and found that they can significantly improve the thermal stability of PVC [19,20]. Wang et al designed and synthesized a kind of biuracil derivative with high thermal stability and transparency for PVC [21,22]. The key factor to explain the mechanism of uracil derivatives on the thermal stability of PVC is the amino group, which can replace the unstable chlorine atoms on PVC chain and absorb the HCl released by PVC degradation.…”

Tensile properties, thermal stability, and the mechanism of PVC stabilized with zinc and calcium oxolinic complexes

“…The research of zinc complexes 16,17 and organic thermal stabilizers [18][19][20] reported by our group showed that the carboxylate groups not only attract the zinc ion but also can replace the unstable chlorine atom on PVC chains, which inhibits the zipper-like dehydrochlorination of PVC. Additionally, an electron shift can be produced on the connected amino group in the double-ring structure of zinc norfloxacin, which leads to the strong absorption of HCl and the delay of the autocatalytic effect, that the released HCl accelerates the removal of other HCl molecules from PVC chains.…”

Evaluation of the stability of rigid poly(vinyl chloride)/biologically active phthalimido phenyl urea composites using thermogravimetric analysis

“…Because the time of fabrication of PVC is relatively short, and determination of the amount of stabilizer consumed after various processing times indicates that most of the stabilizer remains unreacted, the final product contains M A N U S C R I P T A C C E P T E D ACCEPTED MANUSCRIPT 4 large amount of heat stabilizer. For this, recently, a class of organic thermal stabilizers possessing antimicrobial activity has been developed to obtain thermally stable antimicrobial PVC composites to be utilized in various biomedical applications [10][11][12].…”