Novel Orthobunyavirus in Cattle, Europe, 2011

Hoffmann, Bernd; Scheuch, Matthias; Höper, Dirk W.; Jungblut, Ralf; Holsteg, Mark; Schirrmeier, Horst; Eschbaumer, Michael; Goller, Katja V.; Wernike, Kerstin; Fischer, Melina; Breithaupt, Angele; Mettenleiter, Thomas C.; Beer, Martin

doi:10.3201/eid1803.111905

Cited by 596 publications

(715 citation statements)

References 7 publications

Supporting

Mentioning

670

Contrasting

Unclassified

Order By: Relevance

“…The clinical signs of SBV infection in cattle can be increased body temperature, reduced milk yield and diarrhoea, and, like other members of this group, i.e. Akabane virus, the virus also infects the embryo or fetus of ruminants and can cause severe malformation (Bilk et al, 2012;Hoffmann et al, 2012;Wernike et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Analysis of the humoral immune response against the envelope glycoprotein Gc of Schmallenberg virus reveals a domain located at the amino terminus targeted by mAbs with neutralizing activity

Roman-Sosa

Brocchi

Schirrmeier

et al. 2016

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

Orthobunyaviruses are enveloped viruses that are arthropod-transmitted and cause disease in humans and livestock. Viral attachment and entry are mediated by the envelope glycoproteins Gn and Gc, and the major glycoprotein, Gc, of certain orthobunyaviruses is targeted by neutralizing antibodies. The domains in which the epitopes of such antibodies are located on the glycoproteins of the animal orthobunyavirus Schmallenberg virus (SBV) have not been identified. Here, we analysed the reactivity of a set of mAbs and antisera against recombinant SBV glycoproteins. The M-segment-encoded proteins Gn and Gc of SBV were expressed as full-length proteins, and Gc was also produced as two truncated forms, which consisted of its amino-terminal third and carboxyl-terminal two-thirds. The sera from convalescent animals reacted only against the full-length Gc and its subdomains and not against the SBV glycoprotein Gn. Interestingly, the amino-terminal domain of SBV-Gc was targeted not only by polyclonal sera but also by the majority of murine mAbs with a neutralizing activity. Furthermore, the newly defined amino-terminal domain of about 230 aa of the SBV Gc protein could be affinity-purified and further characterized. This major neutralizing domain might be relevant for the development of prophylactic, diagnostic and therapeutic approaches for SBV and other orthobunyaviruses.

show abstract

Section: Introductionmentioning

confidence: 99%

Analysis of the humoral immune response against the envelope glycoprotein Gc of Schmallenberg virus reveals a domain located at the amino terminus targeted by mAbs with neutralizing activity

Roman-Sosa

Brocchi

Schirrmeier

et al. 2016

Journal of General Virology

Self Cite

View full text Add to dashboard Cite

show abstract

“…Outbreaks in northern Europe of bluetongue virus (Carpenter, 2009), and recently Schmallenberg virus (Hoffmann et al, 2012), have demonstrated the devastating effect of midge-borne viruses on naïve livestock populations. Subsequently, there has been increased concern over the risk of introduction of other midge-borne viruses, such as AHSV, and the need for evidence-based control strategies (Carpenter et al, 2008a(Carpenter et al, , 2009MacLachlan and Guthrie, 2010;Papadopoulos et al, 2010;Backer and Nodelijk, 2011;MacLachlan and Mayo, 2013;Napp et al, 2013;Robin et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

Efficacy of alphacypermethrin-treated high density polyethylene mesh applied to jet stalls housing horses against Culicoides biting midges in South Africa

Page

Labuschagne

Venter

et al. 2015

Veterinary Parasitology

View full text Add to dashboard Cite

The efficacy of alphacypermethrin-treated high density polyethylene (HDPE) mesh applied to jet stalls against Culicoides biting midges (Diptera: Ceratopogonidae) was determined by mechanical aspiration of midges from horses and using Onderstepoort 220V downdraught black light traps in four blocks of a 3 x 2 randomised design under South African field conditions. The alphacypermethrintreated HDPE mesh applied to the stall significantly (P = 0.008) reduced the number of Culicoides midges, predominantly Culicoides (Avaritia) imicola Kieffer, mechanically aspirated from horses housed in the stall. The mesh reduced the Culicoides midge attack rate in the treated stall compared to the untreated stall and a sentinel horse by 6 times and 14 times, respectively. The number of Culicoides midges and C. imicola collected in light traps from the untreated and alphacypermethrin HDPE mesh-treated stalls did not differ significantly (P = 0.82). Alphacypermethrin-treated HDPE mesh could be used to reduce exposure of horses in jet stalls to Culicoides midges, specifically C. imicola, and the risk of midge-borne Orbivirus transmission.

show abstract

“…Bluetongue (BT) and Schmallenberg diseases (SB) have been reported in northern Europe in recent years (Thiry et al, 2006;Hoffmann et al, 2012). BT is an infectious and non-contagious disease first described in South Africa (Anon., 1876), of which serotype 8 was detected for the first time in northern Europe in August 2006 (Thiry et al, 2006).…”

Section: Introductionmentioning

confidence: 99%

Orientation behaviour of Culicoides obsoletus (Diptera: Ceratopogonidae), a relevant virus vector in northern Europe, toward host-associated odorant cues

Zimmer

Verheggen

Haubruge

et al. 2015

Veterinary Parasitology

View full text Add to dashboard Cite

a b s t r a c tSome Culicoides biting midge species (Diptera: Ceratopogonidae) are biological virus vectors worldwide and have recently been associated with outbreaks of important epizootic diseases such as bluetongue and Schmallenberg in northern Europe. These diseases, which affect domestic and wild ruminants, have caused considerable economic losses. Knowledge of host preferences of these biting midges -especially of the relevant vectors of arboviruses near farms, such as Culicoides obsoletus in northern Europe -is essential to understand pathogen transmission cycles and the epidemiology of associated diseases. This study aimed to determine host preferences of C. obsoletus using an in-field flight tunnel containing pairs of calf, sheep, chicken, and human hosts (and controls) and a laboratory two-choice bioassay containing volatile extracts of host skin (and controls). Behavioural responses of nulliparous C. obsoletus females in the in-field flight tunnel showed a preference for human (but also calf and sheep) hosts, probably due to their exhalation of greater quantities of carbon dioxide. The laboratory experiment revealed that volatile organic compounds released from the skin of chicken and sheep seemed to attract this species. Culicoides obsoletus, thus, seems to have a wide host range and to be particularly attracted by humans under field conditions. A better understanding of vector-host interaction could enable the development of control strategies against adult biting midges, by exploiting insect-repelling or -attractive semiochemicals. Volatile extracts of chicken and/or sheep skin could be used to identify volatile compounds attractive to C. obsoletus, which in turn could be used in baited traps.

show abstract

Novel Orthobunyavirus in Cattle, Europe, 2011

Cited by 596 publications

References 7 publications

Analysis of the humoral immune response against the envelope glycoprotein Gc of Schmallenberg virus reveals a domain located at the amino terminus targeted by mAbs with neutralizing activity

Analysis of the humoral immune response against the envelope glycoprotein Gc of Schmallenberg virus reveals a domain located at the amino terminus targeted by mAbs with neutralizing activity

Efficacy of alphacypermethrin-treated high density polyethylene mesh applied to jet stalls housing horses against Culicoides biting midges in South Africa

Orientation behaviour of Culicoides obsoletus (Diptera: Ceratopogonidae), a relevant virus vector in northern Europe, toward host-associated odorant cues

Contact Info

Product

Resources

About