Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

Sprio, Simone; Dapporto, Massimiliano; Montesi, Monica; Panseri, Silvia; Lattanzi, Wanda; Pola, Enrico; Logroscino, Giandomenico; Tampieri, Anna

doi:10.3390/ma9090763

Cited by 25 publications

(28 citation statements)

References 62 publications

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“…The injectable biomaterials represent an excellent strategy to improve the interaction of the material itself with the surrounding tissues in osteoporotic patients [ 29 – 31 ]. In the present study, it has been demonstrated that novel injectable strontium-doped apatitic bone cements [ 22 ], influenced the viability, morphology and gene expression profiling of bone cells. A detailed morphological analysis showed MSCs and OBs well attached and spread on all the cement surfaces with their characteristic morphology.…”

Section: Discussionmentioning

confidence: 94%

“…Sr-doped HA cements were prepared as reported in our previous work [ 22 ]. Briefly, Sr-substituted αTCP powders with different strontium content (i.e.…”

Section: Methodsmentioning

confidence: 99%

“…In the present work, Sr-doped hydroxyapatite (HA) bone cements were prepared by mixing Sr-substituted αTCP phases with setting solutions enriched with sodium alginate, as already described and characterized in our previous work [ 22 ], and for the first time were deeper biological evaluates in vitro , to investigate its biological effect on mouse mesenchymal stem cells (MSCs), pre-osteoblasts (OBs) and osteoclasts (OCLs).…”

Section: Introductionmentioning

confidence: 99%

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Sr-substituted bone cements direct mesenchymal stem cells, osteoblasts and osteoclasts fate

et al. 2017

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Strontium-substituted apatitic bone cements enriched with sodium alginate were developed as a potential modulator of bone cells fate. The biological impact of the bone cement were investigated in vitro through the study of the effect of the nanostructured apatitic composition and the doping of strontium on mesenchymal stem cells, pre-osteoblasts and osteoclasts behaviours. Up to 14 days of culture the bone cells viability, proliferation, morphology and gene expression profiles were evaluated. The results showed that different concentrations of strontium were able to evoke a cell-specific response, in fact an inductive effect on mesenchymal stem cells differentiation and pre-osteoblasts proliferation and an inhibitory effect on osteoclasts activity were observed. Moreover, the apatitic structure of the cements provided a biomimetic environment suitable for bone cells growth. Therefore, the combination of biological features of this bone cement makes it as promising biomaterials for tissue regeneration.

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Section: Discussionmentioning

confidence: 94%

“…Sr-doped HA cements were prepared as reported in our previous work [ 22 ]. Briefly, Sr-substituted αTCP powders with different strontium content (i.e.…”

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Sr-substituted bone cements direct mesenchymal stem cells, osteoblasts and osteoclasts fate

et al. 2017

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“…On the basis of these results, a selected Sr-HA cement formulation was further tested in vivo in a rabbit model by compositional, morphological, and histological/histomorphometric analysis. The cement exhibited complete transformation into HA, thus showing a biomimetic composition, and enhanced the ability to induce new bone formation and penetration, provided also by its porous microstructure [65].…”

Section: Injectable Self-hardening Bone Cements With Biomimetic Compomentioning

confidence: 98%

Nature-Inspired Processes and Structures: New Paradigms to Develop Highly Bioactive Devices for Hard Tissue Regeneration

Preti¹,

Lambiase²,

Campodoni³

et al. 2019

Bio-Inspired Technology [Working Title]

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Material scientists are increasingly looking to natural structures as inspiration for new-generation functional devices. Particularly in the medical field, the need to regenerate tissue defects claims, since decades, biomaterials with the ability to instruct cells toward formation and organization of new tissue. It is today increasingly accepted that biomimetics is a leading concept for biomaterials development. In fact, there is increasing evidence that the use of biomedical devices showing substantial mimicry of the composition and multi-scale structure of target native tissues have enhanced regenerative ability. As a relevant example, biomimetic materials have high potential to solve degenerative diseases affecting the musculoskeletal system, namely, bone, cartilage and articular tissues, which is of pivotal importance for most of human abilities, such as walking, running, manipulating, and chewing. In this respect, the adoption of nature-inspired processes and structures is an emerging fabrication concept, uniquely able to provide biomaterials with superior biological performance. The chapter will give an overview of the most recent results obtained in the field of hard tissue regeneration by using 3D biomaterials obtained by nature-inspired approaches. The main focus is given to porous hydroxyapatitebased ceramic or hybrid scaffolds for regeneration of bone and osteochondral tissues in neurosurgery and orthopedics.

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“…Calcium phosphates are also the base of inorganic bone cements with good osteoinductive potential ( Dorozhkin, 2008 ; Boanini et al, 2010 ; Bohner, 2010 ; Schumacher et al, 2013 ; Sprio et al, 2016a ). An important advantage of calcium phosphate cements is the ability of self-hardening by dissolution/reprecipitation processes occurring in vivo at body temperature that yields the transformation of metastable calcium phosphates into calcium-deficient HA with acicular morphology.…”

Section: Biomaterials For Bone Tissue Applicationsmentioning

confidence: 99%

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

Guerrieri

Montesi

Sprio

et al. 2020

Front. Bioeng. Biotechnol.

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Bone is the third most frequent site of metastasis, with a particular incidence in breast and prostate cancer patients. For example, almost 70% of breast cancer patients develop several bone metastases in the late stage of the disease. Bone metastases are a challenge for clinicians and a burden for patients because they frequently cause pain and can lead to fractures. Unfortunately, current therapeutic options are in most cases only palliative and, although not curative, surgery remains the gold standard for bone metastasis treatment. Surgical intervention mostly provides the replacement of the affected bone with a bioimplant, which can be made by materials of different origins and designed through several techniques that have evolved throughout the years simultaneously with clinical needs. Several scientists and clinicians have worked to develop biomaterials with potentially successful biological and mechanical features, however, only a few of them have actually reached the scope. In this review, we extensively analyze currently available biomaterials-based strategies focusing on the newest and most innovative ideas while aiming to highlight what should be considered both a reliable choice for orthopedic surgeons and a future definitive and curative option for bone metastasis and cancer patients.

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Novel Osteointegrative Sr-Substituted Apatitic Cements Enriched with Alginate

Cited by 25 publications

References 62 publications

Sr-substituted bone cements direct mesenchymal stem cells, osteoblasts and osteoclasts fate

Sr-substituted bone cements direct mesenchymal stem cells, osteoblasts and osteoclasts fate

Nature-Inspired Processes and Structures: New Paradigms to Develop Highly Bioactive Devices for Hard Tissue Regeneration

Innovative Options for Bone Metastasis Treatment: An Extensive Analysis on Biomaterials-Based Strategies for Orthopedic Surgeons

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