Novel oxoisochromene synthesisviachemoselective O–H insertion of 1,3-dicarbonyl compounds and subsequent Pd-catalyzed intramolecular arylation reaction

Abstract

Chemoselective O-alkylation of 1,3-diketones is a formidable synthetic challenge due to competing C-alkylation reaction. In this report, N-triftosylhydrazones derived from 2-bromo(hetero)arylaldehydes are utilized for the O-alkylation of cyclic 1,3-diketones under...