Novel, oxygenated clinoptilolite material efficiently removes aluminium from aluminium chloride-intoxicated rats in vivo

Pavelić, Sandra Kraljević; Micek, Vedran; Filošević, Ana; Gumbarević, Darko; Žurga, Paula; Bulog, Aleksandar; Orct, Tatjana; Yamamoto, Yasuaki; Preočanin, Tajana; Plavec, Janez; Peter, Robert; Petravić, M.; Vikić‐Topić, Dražen; Pavelić, Krešimir

doi:10.1016/j.micromeso.2017.04.062

Cited by 32 publications

(31 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Activation may be performed either through chemical treatment, e.g., with an acid, by replacing stabilizing cations, or through mechanical modifications by means of different micronization methods, which may all increase the surface area and change the ion-exchange properties and adsorption capacity ( Abdulkerim, 2012 ; Akimkhan, 2012 ; Canli et al, 2013b ). In the paper by Kraljević Pavelić et al (2017) , it was specifically shown that different micronization methods change the clinoptilolite tuff properties by affecting the surface area, pore size, and silicon to aluminum ratio on the surface of the material. Moreover, hydrochloric acid (HCl) that is also present in the stomach may change clinoptilolite physical chemical properties and has been proven to enhance the clinoptilolite ion-exchange capacity for Cu 2+ and Co 2+ in a synthetic Cu-Co solution at concentrations relevant for the stomach in vivo (0.1 M) ( MambaI et al, 2010 ).…”

Section: Zeolites Effects On Oxidative Stress and Immune Systemmentioning

confidence: 99%

“…In vivo , the acid concentrations of the intestine are substantially lower than those used in industrial activation process. For instance, gastric acid in the stomach contains HCl at 0.05–0.1 M. In such an environment, a certain release of Al species from the clinoptilolite surface may well be hypothesized even though aluminum from the clinoptilolite materials does not enter the blood or accumulate in the body as shown in athletes supplemented with zeolite-clinoptilolite supplement ( Lamprecht et al, 2015 ) or healthy rats supplemented with different clinoptilolite materials ( Kraljević Pavelić et al, 2017 ) where aluminum released into systemic circulation was observed only in rats supplemented with synthetic zeolite A. The latter effect was attributed to the zeolite A lower stability in the acidic pH relevant for the human intestine in comparison to clinoptilolite materials.…”

Section: Zeolites Effects On Oxidative Stress and Immune Systemmentioning

confidence: 99%

See 1 more Smart Citation

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

et al. 2018

Self Cite

View full text Add to dashboard Cite

Unique and outstanding physical and chemical properties of zeolite materials make them extremely useful in a variety of applications including agronomy, ecology, manufacturing, and industrial processes. Recently, a more specific application of one naturally occurring zeolite material, clinoptilolite, has been widely studied in veterinary and human medicine. Due to a number of positive effects on health, including detoxification properties, the usage of clinoptilolite-based products in vivo has increased enormously. However, concerns have been raised in the public about the safety of clinoptilolite materials for in vivo applications. Here, we review the scientific literature on the health effects and safety in medical applications of different clinoptilolite-based materials and propose some comprehensive, scientifically-based hypotheses on possible biological mechanisms underlying the observed effects on the health and body homeostasis. We focus on the safety of the clinoptilolite material and the positive medical effects related to detoxification, immune response, and the general health status.

show abstract

Section: Zeolites Effects On Oxidative Stress and Immune Systemmentioning

confidence: 99%

Section: Zeolites Effects On Oxidative Stress and Immune Systemmentioning

confidence: 99%

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…At present, many positive effects are recognized due to the capacity of natural occurring zeolite clinoptilolite (ZC) to adsorb and therefore remove harmful substances like heavy metals, ammonia, or other small molecules in the gastrointestinal tract of humans. It is important to mention that this positive impact can improve through modifications of ZC due to micronization of ZC (M-ZC) or tribomechanical activation of ZC (TMAZ) or double tribomechanical activation of ZC (PMA-ZC), known as Panaceo Micro Activation [4]. This recently developed PMA (Panaceo Micro Activation)-technology is a special tribomechanical micronization process that causes self-collisions of zeolite particles and contributes to increasing the surface charge and the cation exchange of the individual particles, improving the overall therapeutic performance of ZC [5].…”

Section: Introductionmentioning

confidence: 99%

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

et al. 2019

View full text Add to dashboard Cite

Zeolites are porous minerals with high absorbency and ion-exchange capacity. Their molecular structure is a dense network of AlO4 and SiO4 that generates cavities where water and other polar molecules or ions are inserted/exchanged. Even though there are several synthetic or natural occurring species of zeolites, the most widespread and studied is the naturally occurring zeolite clinoptilolite (ZC). ZC is an excellent detoxifying, antioxidant and anti-inflammatory agent. As a result, it is been used in many industrial applications ranging from environmental remediation to oral applications/supplementation in vivo in humans as food supplements or medical devices. Moreover, the modification as micronization of ZC (M-ZC) or tribomechanically activated zeolite clinoptilolite (TMAZ) or furthermore as double tribomechanically activated zeolite clinoptilolite (PMA-ZC) allows improving its benefits in preclinical and clinical models. Despite its extensive use, many underlying action mechanisms of ZC in its natural or modified forms are still unclear, especially in humans. The main aim of this review is to shed light on the geochemical aspects and therapeutic potentials of ZC with a vision of endorsing further preclinical and clinical research on zeolites, in specific on the ZC and its modified forms as a potential agent for promoting human brain health and overall well-being.

show abstract

“…Mainly zeolites consists of alumino and silicates (Jha, and Singh, 2016) and many positive effects are occurred as removing harmful toxic materials like heavy metals, ammonia and other small molecules in gastrointestinal tract (Kraljevic et al 2017). Zeolite materials classified to two different materials, natural zeolite (clinoptilolite) and synthetic zeolite (NaP1).…”

Section: Introductionmentioning

confidence: 99%

“…Moreover, zeolite is commonly used in dairy cow rations to reduce the impact of mycotoxins in the feed and negative impact of mold produced toxins in animal feeds (Kirolove et al 1993). Many positive effects are occurred as removing harmful toxic materials like heavy metals, ammonia and other small molecules in gastrointestinal tract (Kraljevic et al 2017), So that it considerably used in animal feeds as a pellet binder for improving ammonia utilization and reduce toxins, heavy metals and metabolic disorders (Bechtel and Hutchenson, 2003). Moreover, Zeolites are utilized for a large range to protect from symptoms of diiarrhea and milk fever (Papaioannou et al 2005).…”

Section: Introductionmentioning

confidence: 99%

Effect of Toxin Binder on Productive Performance of Lactating Friesian Cows

Mehany

Shams

2019

Journal of Animal and Poultry Production

View full text Add to dashboard Cite

Twenty Friesian cows with an average weight of 540  17.59 kg and running on 2nd to 5th lactating season were used at 60 days before calving and continued up to 120 days of lactation feeding trial to study the effect of toxin binder (bentonite and zeolite) on Productive Performance of Lactating Cows. Cows were randomly divided into four similar groups (n = 3). All cows were received basal rations (BR) that consists of concentrate feed mixture (CFM), corn silage (CS) and rice straw (RS). Group 1 received (BR) without supplement and served as control rations, whereas groups G2, G3 and G4 received control diet plus 2% Bentonite, 1% Bentonite plus 1% Zeolite or 2% Zeolite of DM intake as tested rations, respectively. Results showed that, supplemented groups were significant (P˂0.05) higher intake of total DM, TDN and DCP than unsuplemented group. Also on the same trend, the concentrations of pH and TVFA's were increased significantly (P˂0.05), while ammonia-N decreased significantly (P˂0.05) in supplemented groups compared to G1. Group 2 recorded significantly (P˂0.05) the highest concentrations of total protein, globulin, glucose and T3 and followed by G3 and G4, while G1 had the lowest values. While, albumin concentration decreased significantly (P˂0.05) with bentonite and zeolite additives. While, the concentrations of creatinine, urea, total lipid and Ca as well as the activity of AST and ALT were nearly similar for the different groups. Yield of actual milk and 4% FCM were significantly (P˂0.05) higher in G2 than those of G4 and G1, And no significant higher than G3 ration: G2 showed significantly (P˂0.05) the highest contents of fat, protein, lactose, SNF and TS, while G1 had the lowest values. Ash content in milk was nearly similar for the different groups. Bentonite and zeolite supplementation improved feed conversion, and G2 recorded the best one. The difference were only significant between bentonite ration (G2) and the control one (G1). Group2 recorded the highest daily feed cost, output of 4% FCM yield, net revenue and economic efficiency followed by G3 and G4, while G1 had the lowest feed cost, net revenue and economic efficiency, while feed cost per one kg 4% FCM was lower significantly (P˂0.05) with G2 followed by G3 and G4, while G1 had the highest value. In conclusion, bentonite supplement for lactating Friesian cows at the level of 2% of DM intake as toxin binder had the best positive effect on digestibility, rumen fermentation, some blood parameters, feed intake, milk yield and composition, feed conversion and economic efficiency, comparison with other supplemented rations and the control one (unsupplemented).

show abstract

Novel, oxygenated clinoptilolite material efficiently removes aluminium from aluminium chloride-intoxicated rats in vivo

Cited by 32 publications

References 40 publications

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

Critical Review on Zeolite Clinoptilolite Safety and Medical Applications in vivo

Zeolite Clinoptilolite: Therapeutic Virtues of an Ancient Mineral

Effect of Toxin Binder on Productive Performance of Lactating Friesian Cows

Contact Info

Product

Resources

About