Novel paper-based diagnostic devices for early detection of cancer

Mousavizadegan, Maryam; Roshani, Amirreza; Hosseini, Morteza

doi:10.1016/b978-0-12-823424-2.00015-6

Biosensor Based Advanced Cancer Diagnostics 2022

DOI: 10.1016/b978-0-12-823424-2.00015-6

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Novel paper-based diagnostic devices for early detection of cancer

Maryam Mousavizadegan

Amirreza Roshani

Morteza Hosseini

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Cited by 3 publications

References 75 publications

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Machine learning-assisted image-based optical devices for health monitoring and food safety

Mousavizadegan,

Shalileh,

Mostajabodavati

et al. 2024

TrAC Trends in Analytical Chemistry

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Machine learning-assisted image-based optical devices for health monitoring and food safety

Mousavizadegan,

Shalileh,

Mostajabodavati

et al. 2024

TrAC Trends in Analytical Chemistry

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A simple and low-cost paper-based device for simultaneous determination of hematocrit and hemoglobin levels in point-of-care settings

Ram,

Kumar,

Paik

et al. 2023

Physics of Fluids

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Hematocrit and hemoglobin levels are common blood tests used to assess the overall health status of patients as well as the oxygen-carrying capacity of the blood. The gold-standard technologies to determine the hematocrit and hemoglobin levels are precise and fast, but they are not pragmatic in extreme point-of-care settings due to the prohibitive cost, process complexity, and sophisticated facilities. Therefore, here, we report the development of a microfluidic paper-based analytical device to determine hematocrit and hemoglobin levels simultaneously. This device exploits the area of the stain formed by a spreading drop of 20 μl of whole blood on Whatman filter paper immobilized with sodium chloride and ethylenediaminetetraacetic acid for hematocrit level, whereas for hemoglobin concentration, it utilizes the gray color intensity of a 20 μl droplet of a mixture of blood and de-ionized water. The performance of the device is verified by comparing with gold-standard results of the automated hematology analyzer, showing a high degree of correlation (R2) of 0.9651 and 0.9701 for hematocrit and hemoglobin levels, respectively. The bias and standard deviation of the differences between the two measurements for hematocrit determination are 0.002 and 1.005, respectively, while the bias and standard deviation of differences between the two methods for hemoglobin determination are 0.065 and 0.398, respectively. This device is likely to provide a simple, fast, disposable, and inexpensive tool to determine the hematocrit and hemoglobin levels in resource-constraint settings.

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Process intensification using immobilized enzymes

Bolat

Greifenstein

Franzreb

et al. 2023

Physical Sciences Reviews

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The application potential of enzymes is undoubtedly very high. However, despite the very large number of different enzymes and enzyme activities, the number of industrial enzyme processes is comparatively small. The particular challenge often lies in transferring promising laboratory processes to an industrial scale. Here, the required performance parameters, such as enzyme stability or productivity, must be achieved. On the one hand, this can be achieved by improving the enzymes. On the other hand, the key performance indicators can often only be achieved by using technical systems in the sense of process intensification. In enzymatic processes, immobilization of enzymes is often the means of choice to enable technical processes. The aim of this article is to outline the most important enzyme immobilization methods and to summarize the most important performance indicators of immobilized enzymes. Finally, the different immobilization methods and performance indicators are compared in a case study with unspecific peroxygenase.

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Novel paper-based diagnostic devices for early detection of cancer

Cited by 3 publications

References 75 publications

Machine learning-assisted image-based optical devices for health monitoring and food safety

Machine learning-assisted image-based optical devices for health monitoring and food safety

A simple and low-cost paper-based device for simultaneous determination of hematocrit and hemoglobin levels in point-of-care settings

Process intensification using immobilized enzymes

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