Novel peroral dosage forms with protease inhibitory activities. II. Design of fast dissolving poly(acrylate) and controlled drug-releasing capsule formulations with trypsin inhibiting properties

Akiyama, Yohko; Lueβen, Henrik L.; Boer, A.G. de; Verhoef, J.; Junginger, Hans E.

doi:10.1016/0378-5173(96)04504-8

Cited by 19 publications

(5 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Recently, researchers have described the nucleation of calcium phosphate crystals on the surface of poly(2-hydroxyethyl methacrylate) polymers which were chemically modified by carboxy-methylation [23]. Other studies have shown that carboxyl-containing molecules are good binders of calcium [24][25][26] and when incorporated into a calcium phosphate material, these molecules were slowly released from the carrier [16].…”

Section: Discussionmentioning

confidence: 99%

Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy

Stigter

Bezemer

Groot

et al. 2004

Journal of Controlled Release

406

279

View full text Add to dashboard Cite

Section: Discussionmentioning

confidence: 99%

Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy

Stigter

Bezemer

Groot

et al. 2004

Journal of Controlled Release

406

279

View full text Add to dashboard Cite

“…These systems have been developed to protect orally administered peptide-based drugs from enzymatic degradation in the gastrointestinal lumen. Some mucoadhesive polymers including carbomer could also act as weak enzyme inhibitors [ 133 ], however, chitosan lacks this property. Examples of enzyme inhibitors include antipain, chymostatin, elastatinal and Bowman-Birk inhibitor [ 134 ].…”

Section: Mucoadhesive Chitosan Derivativesmentioning

confidence: 99%

Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems

2018

View full text Add to dashboard Cite

Mucoadhesive drug delivery systems are desirable as they can increase the residence time of drugs at the site of absorption/action, provide sustained drug release and minimize the degradation of drugs in various body sites. Chitosan is a cationic polysaccharide that exhibits mucoadhesive properties and it has been widely used in the design of mucoadhesive dosage forms. However, its limited mucoadhesive strength and limited water-solubility at neutral and basic pHs are considered as two major drawbacks of its use. Chemical modification of chitosan has been exploited to tackle these two issues. In this review, we highlight the up-to-date studies involving the synthetic approaches and description of mucoadhesive properties of chitosan and chitosan derivatives. These derivatives include trimethyl chitosan, carboxymethyl chitosan, thiolated chitosan, chitosan-enzyme inhibitors, chitosan-ethylenediaminetetraacetic acid (chitosan-EDTA), half-acetylated chitosan, acrylated chitosan, glycol chitosan, chitosan-catechol, methyl pyrrolidinone-chitosan, cyclodextrin-chitosan and oleoyl-quaternised chitosan. We have particularly focused on the effect of chemical derivatization on the mucoadhesive properties of chitosan. Additionally, other important properties including water-solubility, stability, controlled release, permeation enhancing effect, and in vivo performance are also described.

show abstract

“…Moreover, it has also been posited that soy isoflavones inhibit insulin release from the pancreas and glucose uptake into the intestinal brush border by restraining protein tyrosine kinase activity (Akiyama et al, 1996) or decreasing sodium-dependent glucose transporters (Vedavanam et al, 1999). An alternative hypothesis is that soy isoflavones are a marker of a healthy soy-based diet.…”

Section: Resultsmentioning

confidence: 99%

The Effect of Different milk types and its yoghurt by various types of Bacterial Culture on Rats induced to Diabetes.

Mostafa

Ebrahim

Nagib

et al. 2020

المجلة المصریة للدراسات المتخصصة

View full text Add to dashboard Cite

Diabetes is a global health problem in the world. Probiotic therapies are going to be an effective alternative therapeutic strategy in the treatment and management of diabetes. The objective of this study was to evaluate the effect of different milk types, conventional yoghurt and probiotic yoghurt from bifidobacterium on serum blood glucose, lipid profile, liver and liver enzymes for rats induced to diabetes .In this study, two strains of conventional yogurt, Lactobacillus Bulgaricus and streptococcus salivarius and in combination with either probiotics bacteria bifidobacteria infantisandBifidobacteria longum B6 for the production of fermented soymilk and cow milk for feeding 96 male albino rats induced with STZ.Results revealed that fermented soymilk by Bifidobacteria was able to significantly decrease glucose levels, total cholesterol concentrations and triacylglycerols compared to conventional yogurt types and milk types.In conclusion soy-protein consumption reduces serum blood glucose and lipid profile for rats induced to diabetes.

show abstract

Novel peroral dosage forms with protease inhibitory activities. II. Design of fast dissolving poly(acrylate) and controlled drug-releasing capsule formulations with trypsin inhibiting properties

Cited by 19 publications

References 26 publications

Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy

Incorporation of different antibiotics into carbonated hydroxyapatite coatings on titanium implants, release and antibiotic efficacy

Chitosan and Its Derivatives for Application in Mucoadhesive Drug Delivery Systems

The Effect of Different milk types and its yoghurt by various types of Bacterial Culture on Rats induced to Diabetes.

Contact Info

Product

Resources

About