Novel pH-sensitive blend microspheres for controlled release of nifedipine – An antihypertensive drug

Phadke, Keerti V.; Manjeshwar, Lata S.; Aminabhavi, Tejraj M.

doi:10.1016/j.ijbiomac.2015.01.045

Cited by 11 publications

(9 citation statements)

References 32 publications

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“…The glass transition temperature of CS grafted AAM increased to 219°C with respect to the pure CS due to the increase in the AAM chain length of the polymer as shown in the Fig. 3b [13]. No peak was observed at the endothermic peak of nitrendipine as shown in the Fig.…”

Section: Dscmentioning

confidence: 86%

“…Sodium alginate coating was used to improve the hydrophilic nature of microspheres. Many researchers [4,[13][14][15][16][17][18][19] obtained the similar results and the formed microspheres were used as the controlled drug release devices.…”

Section: Preparation Of Microspheresmentioning

confidence: 88%

“…Graft copolymerization of CS with AAM was carried out at different ratios 1:3, 1:5, and 1:7. In 160 ml of 4% acetic acid solution, 2 g of CS was dissolved [13]. Then, a solution of 14 g of AAm in double-distilled and deionized water was added, where the ratio of CS and AAm is 1:7.…”

Section: Preparation Of Copolymermentioning

confidence: 99%

“…Equal amounts of grafted copolymer and polyvinyl alcohol (PVA) were added with double distilled deionized water to form the 20 ml of 6% (w/v) polymer solution [13]. A small volume of alcohol was added to this mixture and stirred it to get the homogeneous solution.…”

Section: Preparation Of Blend Microspheresmentioning

confidence: 99%

“…2b. For the controlled release of Nitrendipine microspheres loaded with different polymers and additives,Nifedipine interpenetrating network microsphere blended with grafted copolymers, Theophylline and isoniazid IPN microspheres encapsulated with hydrophilic polymers and chitosan sodium alginate carbamazepine microspheres shows a smooth surface and rough surface for the unloaded and drug loaded microspheres [13][14][15][16][17][18][19][20]. From the result, we observed that the formed microsphere is suitable for the sustained release studies.…”

Section: Semmentioning

confidence: 99%

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Preparation and Characterization of Nitrendipine Loaded Grafted Copolymer Microspheres: A Preliminary Study

Sindhu

Dharani

Bhavanitha

et al. 2018

Asian J Pharm Clin Res

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Objectives: Developing countries like India suffers mostly from cardiovascular problems and kidney failure. An antihypertensive drug is mainly used to avoid the cardiovascular problems and kidney failure. Nitrendipine is a calcium antagonist widely used in the treatment of hypertension. The bioavailability of drug, when administered orally, is low. Sustained drug delivery systems are using microspheres emerging as an effective method to increase the bioavailability of the drug. The current work involves the encapsulation of nitrendipine - acrylamide grafted chitosan which helps to overcome poor solubility and hydrophobic nature of the nitrendipine. This will enhance the drug dissolution and reduce the side effects of the antihypertensive drug.Methods: By emulsion cross-linking method, grafted copolymers were prepared. The physicochemical interactions between the drug and grafted copolymer were analyzed by scanning electron microscopy (SEM), Fourier-transform infrared spectroscopy (FTIR), and differential scanning calorimetry (DSC).Results: Encapsulated drug and grafted copolymer were characterized by FTIR to understand the chemical interactions and to identify the functional groups present. Morphology and particle size of the grafted copolymer with drug and without drug were assessed by SEM. DSC was used to identify the melting endotherms of a drug, copolymer cross-linked microspheres, and drug encapsulated microspheres.Conclusion: Thus, the drug encapsulated grafted copolymer increases the hydrophilic character and thereby making the polymers feasible for functioning as drug carriers for sustained drug delivery system.

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Section: Dscmentioning

confidence: 86%