Novel Pharmacological Treatment Attenuates Septic Shock and Improves Long-Term Survival

Zhao, Ting C.; Li, Y.; Liu, B.; Liu, Z.; Sillesen, Martin; DePeralta, Danielle K.; Velmahos, George C.; Alam, Hasan B.

doi:10.1016/j.jss.2012.10.659

Cited by 1 publication

(1 citation statement)

References 16 publications

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“…Some recent studies have demonstrated that HDACi can also increase the tolerance of cells to hypoxic inflammatory environments, thus protecting various organs. Li et al (2010); Liu et al (2013), Liu et al (2014) and Zhao et al (2013) showed that HDACi was important for maintaining histone acetylation homeostasis, especially in animals in hypovolemic or septic shock; in addition, HDACi could increase cellular tolerance to hypoxic inflammatory environments, thereby protecting organs and prolonging the life of animals. By causing microglia activation and promoting histone acetylation, VPA affects the MAPK and NF-κB signaling pathways, regulates the expressions of inflammation-related genes, and alleviates the inflammatory response.…”

Section: Inhibitory Effects Of Vpa On the Anti-inflammatory Responsementioning

confidence: 99%

Research Progress in Regulatory Mechanism of Valproic Acid on Inflammatory Responses to Burns and Trauma

Zhu,

Wang,

Liu

2024

Pharmacognosy Magazine

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Inflammation plays an important role in the defense of the human body. The inflammatory response can suppress the spread of pathogens, accelerate the removal of necrotic cells, and repair the damaged tissues and organs. However, an excessive inflammatory response can be fatal as it may lead to cellular apoptosis, necrosis of tissues and organs, and systemic dysfunction. An inflammatory response occurs when the skin is burned or injured, causing more severe and extensive pathological damage to the injured area. For example, inflammation can damage the coagulation system in the capillaries, resulting in the formation of small blood clots in the affected areas. In severe cases, inflammation can lead to necrosis of the injured area and may even affect other uninjured areas, causing hypoxia and inadequate blood supply. The role of valproic acid (VPA), a histone deacetylase inhibitor, has been increasingly recognized in recent years. Evidence suggests that VPA can effectively alleviate tissue and organ injuries secondary to ischemia and hypoxia, and improve the body’s tolerance to ischemia-hypoxia and inflammatory insults, thus increasing the survival rates of the patients. This article reviews the latest research progress made in the mechanisms by which VPA regulates inflammatory response to burns.

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Section: Inhibitory Effects Of Vpa On the Anti-inflammatory Responsementioning

confidence: 99%

Research Progress in Regulatory Mechanism of Valproic Acid on Inflammatory Responses to Burns and Trauma

Zhu,

Wang,

Liu

2024

Pharmacognosy Magazine

View full text Add to dashboard Cite

show abstract

Novel Pharmacological Treatment Attenuates Septic Shock and Improves Long-Term Survival

Cited by 1 publication

References 16 publications

Research Progress in Regulatory Mechanism of Valproic Acid on Inflammatory Responses to Burns and Trauma

Research Progress in Regulatory Mechanism of Valproic Acid on Inflammatory Responses to Burns and Trauma

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