Novel phosphoramidates with porphine and nitrogenous drug: One-pot synthesis and orientation to cancer cells

New AB3-type porphyrins with piperidine and morpholine motifs; synthesis and photo-physicochemical and biological properties

“…of pyrrole in propionic acid at reflux. 38 The unsymmetrical meso substituted AB 3 -type porphyrin containing hydroxyl functionality 1 was synthesized by utilizing the reported procedure. 38 It is well established that the hydroxyl group is an important functional group to introduce an additional substituent to an organic molecule.…”

“…38 The unsymmetrical meso substituted AB 3 -type porphyrin containing hydroxyl functionality 1 was synthesized by utilizing the reported procedure. 38 It is well established that the hydroxyl group is an important functional group to introduce an additional substituent to an organic molecule. Compound 1 comprising a hydroxyl moiety can be utilized as a precursor for the preparation of the targeted AB 3 -type porphyrins.…”

“…The starting material, meso substituted AB 3 -type porphyrin 1 , was synthesized according to the literature. 38 The synthesis, characterization and obtained spectral data of the targeted compounds are presented in the ESI (Fig. S1 and S18) †…”

“…Compound 1 was prepared by using a slightly modified literature procedure. 38 In a round-bottom flask, pyrrole (17.35 mL, 250 mmol), p -bromobenzaldehyde (30.30 g, 164 mmol) and p -hydroxybenzaldehyde (2.00 g, 16.4 mmol) in 200 mL of propionic acid were heated under reflux for 1 h. Afterwards the reaction mixture was cooled down to room temperature. The resulting precipitate was filtered off and washed several times with water until the filtrate was clear.…”

Synthesis, characterization and electrochemical behavior of new bis(fluoroalkyl) ferrocenylphosphonates and their tin tetrachloride complexes

“…Organophosphorus chemistry have gained considerable interest due to their widespread applications in various areas such as agriculture [1,2], biology [3,4], pharmaceuticals [5][6][7] and chemical synthesis [8,9]. Among these, one of the most common classes are phosphonates, which are attracting increasing interest as important structural motifs that are found in a variety of naturally occurring compounds [10][11][12], as anticancer [13,14], inhibitors of hepatitis C virus [15,16], anti-HIV [17] and antimalarial agents [18].…”