Novel phosphorylation‐dependent regulation in an unstructured protein

Cannon, John F.

doi:10.1002/prot.25812

Proteins

2019

DOI: 10.1002/prot.25812

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Novel phosphorylation‐dependent regulation in an unstructured protein

John F. Cannon

Abstract: This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

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Protein phosphatase-1: dual activity regulation by Inhibitor-2

Lemaire

2020

Biochemical Society Transactions

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Inhibitor-2 (I2) ranks amongst the most ancient regulators of protein phosphatase-1 (PP1). It is a small, intrinsically disordered protein that was originally discovered as a potent inhibitor of PP1. However, later investigations also characterized I2 as an activator of PP1 as well as a chaperone for PP1 folding. Numerous studies disclosed the importance of I2 for diverse cellular processes but did not describe a unifying molecular principle of PP1 regulation. We have re-analyzed the literature on I2 in the light of current insights of PP1 structure and regulation. Extensive biochemical data, largely ignored in the recent I2 literature, provide substantial indirect evidence for a role of I2 as a loader of active-site metals. In addition, I2 appears to function as a competitive inhibitor of PP1 in higher eukaryotes. The published data also demonstrate that several segments of I2 that remain unstructured in the PP1 : I2 complex are in fact essential for PP1 regulation. Together, the available data identify I2 as a dynamic activity-modulator of PP1.

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Protein phosphatase-1: dual activity regulation by Inhibitor-2

Lemaire

2020

Biochemical Society Transactions

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Novel phosphorylation‐dependent regulation in an unstructured protein

Abstract: This is the author manuscript accepted for publication and has undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as

Cited by 1 publication

References 80 publications

Protein phosphatase-1: dual activity regulation by Inhibitor-2

Protein phosphatase-1: dual activity regulation by Inhibitor-2

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