Novel Piperine compound AB05 (N-5-(3,4-dimethoxyphenyl) -2E,4E pentadienylpiperidine) inhibits H1N1 influenza virus propagation in vitro

Mohammed, Atif Atif Abdulrahim; Velu, Arul Balaji; Al‐Hakami, Ahmed; Meenakshisundaram, B.; Esther, P.; Abdelwahid, S. A.; Ahmad, Irfan; Rajagopalan, Prasanna; Anantharam, D.; Harish, C. C.

doi:10.47665/tb.37.4.1062

Cited by 3 publications

(2 citation statements)

References 21 publications

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“…Mohammed et al conducted a study in which they screened a piperine derivative 6 ( Figure 3 ) for its antiviral activity and compared it with other strains in vitro on the MDCK cell line. The adsorption assay demonstrated a dose-dependent reduction of viral plaque with an EC 50 value of 0.33 μM [ 39 ]. Over the past five years, the COVID-19 (SARS-CoV-2) epidemic has spread around the world, bringing immeasurable damage to people’s lives and health.…”

Section: Bioactivities Of Piperine and Its Derivativesmentioning

confidence: 99%

Piperine: Chemistry and Biology

Han,

Zhang,

et al. 2023

Toxins

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Piperine is a plant-derived promising piperamide candidate isolated from the black pepper (Piper nigrum L.). In the last few years, this natural botanical product and its derivatives have aroused much attention for their comprehensive biological activities, including not only medical but also agricultural bioactivities. In order to achieve sustainable development and improve survival conditions, looking for environmentally friendly pesticides with low toxicity and residue is an extremely urgent challenge. Fortunately, plant-derived pesticides are rising like a shining star, guiding us in the direction of development in pesticidal research. In the present review, the recent progress in the biological activities, mechanisms of action, and structural modifications of piperine and its derivatives from 2020 to 2023 are summarized. The structure-activity relationships were analyzed in order to pave the way for future development and utilization of piperine and its derivatives as potent drugs and pesticides for improving the local economic development.

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Section: Bioactivities Of Piperine and Its Derivativesmentioning

confidence: 99%

Piperine: Chemistry and Biology

Han,

Zhang,

et al. 2023

Toxins

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“…vaccination of the flocks througout the world (Mohammed et al, 2020). Although amantadine is regularly being used in flocks against influenza A virus incubations, but increased resistance of common drugs draw the attension back on the uses of natural products agaisnt these visuses for control in poultry and other birds.…”

Section: Article History Abstractmentioning

confidence: 99%

Elucidating antiviral activity of Curcuma longa against H9 N2 influenza virus using embryonated chicken egg model

et al. 2021

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Inhibition of the largemouth bass virus replication by piperine demonstrates potential application in aquaculture

Wang

Yang

Ren

et al. 2022

Journal of Fish Diseases

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Largemouth bass virus (LMBV) is a single-molecule linear doublestranded DNA (dsDNA) virus belonging to the genus ranavirus of the family Iridoviridae (Deng et al., 2011;Zhu et al., 2020). LMBV causes >60% mortality in largemouth bass and has been reported from different corners of the world (Deng et al., 2011;Woodland et al., 2002;Zhao et al., 2020). Some parts of China and the Americas, as well as parts of Europe, are affected by frequent LMBV outbreaks (Boonthai et al., 2018;Zhao et al., 2020). LMBV infection has been further expanded with the broader culture and trade of largemouth bass worldwide, thereby increasing the need for antiviral strategies against LMBV.

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Novel Piperine compound AB05 (N-5-(3,4-dimethoxyphenyl) -2E,4E pentadienylpiperidine) inhibits H1N1 influenza virus propagation in vitro

Cited by 3 publications

References 21 publications

Piperine: Chemistry and Biology

Piperine: Chemistry and Biology

Elucidating antiviral activity of Curcuma longa against H9 N2 influenza virus using embryonated chicken egg model

Inhibition of the largemouth bass virus replication by piperine demonstrates potential application in aquaculture

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