Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae

Quinn, John P.; Miyashiro, Deborah; Sahm, Daniel F.; Flamm, Rk; Bush, Karen

doi:10.1128/aac.33.9.1451

Cited by 172 publications

(124 citation statements)

References 34 publications

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“…This finding is consistent with other recently published surveys of Canadian strains (20). This is in sharp contrast to the experience in many other countries where both endemic and epidemic strains are frequently encountered (21)(22)(23)(24)(25).…”

Section: Discussioncontrasting

confidence: 53%

Study of the Comparative Activity of Piperacillin/Tazobactam with Currently Available Antibiotics against 8206 Aerobic Isolates

Forward

Low²,

Laverdière³

et al. 1996

Canadian Journal of Infectious Diseases and Medical Microbiolog

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OBJECTIVES:To compare the activity of piperacillin-tazobactam with piperacillin and other parenterally administered antibiotics against aerobic Gram-negative bacilli and Gram-positive cocci isolated from across Canada, and to determine the prevalence of resistance mediated by extended-spectrum cephalosporinases. METHODS: Sixty-one laboratories participated. Disk diffusion testing was performed in accordance with methods outlined by the National Committee for Clinical Laboratory Standards. Susceptibilities were performed on 8206 strains. Escherichia coli and Klebsiella pneumoniae with reduced susceptibilities to third-generation cephalosporins were screened for extended-spectrum beta-lactamases (ESBLs). RESULTS: Piperacillin-tazobactam was active against 92% of the strains, piperacillin against 81% and ticarcillinclavulanic acid against 88%. Few differences were observed in the relative susceptibility of strains from teaching or community hospitals, from different anatomic sites or from different regions of the country. Aerobic Gram-negative bacilli tested tended to be more susceptible to all the agents than was recently reported in a similar American study. Only 43% of Enterococcus faecium were susceptible to ampicillin and 42% to piperacillin piperacillin with and without tazobactam. Only two enterococcal strains were resistant to vancomycin, and 19 had intermediate zone sizes. Of the 10 strains of E coli and eight strains of K pneumoniae with reduced susceptibility to extended spectrum cephalosporins, only one demonstrated typical ESBL activity. CONCLUSIONS: Canadian aerobic Gram-positive cocci and Gram-negative bacilli remain highly susceptible to many currently available antibiotics. The findings confirm a broad spectrum of activity of piperacillin-tazobactam and indicate that the pattern of susceptibility is quite uniform from different body sites, in both teaching and community hospitals, and across the country.

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Section: Discussioncontrasting

confidence: 53%

Study of the Comparative Activity of Piperacillin/Tazobactam with Currently Available Antibiotics against 8206 Aerobic Isolates

Forward

Low²,

Laverdière³

et al. 1996

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…However, the finding in this study that when both pairs of the combination discs were taken into consideration, a higher proportion of ESBL-producing strains were detected than the rate recorded for either pair taken separately is similar to the report of M'Zali et al (17) in which 86%, 65.5% and 93% of ESBL-producing members of the family Enterobacteriaceae were detected by discs containing ceftazidime, cefotaxime and both agents taken into consideration respectively. Optimal substrate profile varies from one ESBL-producer to another (22). This may explain the differences in the ESBL detection rates by the different cephalosporins.…”

Section: Discussionmentioning

confidence: 99%

Extended-spectrum beta-lactamase production among ampicillin-resistant Escherichia coli strains from chicken in Enugu State, Nigeria

Chah¹,

Oboegbulem²

2007

Braz. J. Microbiol.

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One hundred and seventy-two ampicillin-resistant E. coli strains isolated from commercial chickens in Enugu State, Nigeria, were screened for beta-lactamase production using the broth method with nitrocefin ® as the chromogenic cephalosporin to detect enzyme production. Beta-lactamase producing strains were further examined for extended-spectrum beta-lactamase (ESBL) production using the Oxoid combination discs method. One hundred and seventy (98.8%) of the 172 ampicillin-resistant E. coli strains produced beta-lactamase enzyme. Sixteen (9.4%) beta-lactamase producers were phenotypically confirmed to produce ESBLs. Six of the ESBL producing strains were only detected with ceftazidime versus ceftazidime/clavulanate combination while ten of the ESBL producers were detected with cefotaxime versus cefotaxime/clavulanate combination. Chicken may serve as a reservoir of ESBL-producing E. coli strains which could be transferred to man and other animals.

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“…First reports of ESBLs in the USA in the late 1980s were reported with TEM-type [19] and the major enzymes appear to be the TEM and SHV types, with a minimal appearance of CTX-M types [20]. Both the prevalence of ESBLs and types involved found in the USA are in stark contrast to the epidemiology seen in the rest of the world, including Canada, where outbreaks of CTX-M producing K. pneumoniae have been seen [21].…”

Section: Usamentioning

confidence: 49%

Ventriculitis Associated with Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae after Acupuncture

Park

Ryu

2017

J Neurocrit Care

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Extended spectrum β-lactamases (ESBLs) are enzymes produced by a variety of Gram negative bacteria which confer an increased resistance to commonly used antibiotics. They are a worrying global public health issue as infections caused by such enzymeproducing organisms are associated with a higher morbidity and mortality and greater fiscal burden. Coupled with increasing prevalence rates worldwide and an ever diminishing supply in the antibiotic armamentarium, these enzymes represent a clear and present danger to public health. This article aims to give an overview of the current situation regarding ESBLs, with a focus on the epidemiology and management of such infections.

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Novel plasmid-mediated beta-lactamase (TEM-10) conferring selective resistance to ceftazidime and aztreonam in clinical isolates of Klebsiella pneumoniae

Cited by 172 publications

References 34 publications

Study of the Comparative Activity of Piperacillin/Tazobactam with Currently Available Antibiotics against 8206 Aerobic Isolates

Study of the Comparative Activity of Piperacillin/Tazobactam with Currently Available Antibiotics against 8206 Aerobic Isolates

Extended-spectrum beta-lactamase production among ampicillin-resistant Escherichia coli strains from chicken in Enugu State, Nigeria

Ventriculitis Associated with Extended Spectrum Beta-Lactamase Producing Klebsiella pneumoniae after Acupuncture

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