Novel Pluronic F‐127‐coated ZnO nanoparticles: Synthesis, characterization, and their in‐vitro cytotoxicity evaluation

Abstract

Zinc oxide (ZnO) nanoparticles (NPs) are increasingly recognized for their potential use in various biomedical applications. However, the tendency of bare ZnO NPs to aggregate and their poor stability in the biological environment reduce their biocompatibility and lead to cytotoxicity in normal healthy cells. This study attempted to avoid this by synthesizing a novel Pluronic F-127-coated ZnO NPs and evaluating their cytotoxicity impact on normal healthy human endothelial AE.hy296 cells. The characterization results revealed that Pluronic coating process remarkably enhanced the stability of ZnO NPs and did not alter their desired crystalline structure. The cytotoxicity of bare and Pluronic F-127-coated ZnO NPs were evaluated through MTT assay and microscopy imaging. The results of the cytotoxicity tests showed that Pluronic F-127 modification significantly improved the biocompatibility and reduced the cytotoxicity of ZnO NPs toward the normal endothelial human EA.hy926 cells.Based on their high crystallinity, stability, and biocompatibility, Pluronic F-123-coated ZnO NPs hold promising potential for miscellaneous biomedical applications.

Highly Stable Europium(III) Tetrahedral (Eu4L4)(phen)4 Cage: Structure, Luminescence Properties, and Cellular Imaging

“…A comparison between IR spectra for F127 and (Eu 4 L 4 )(phen) 4 @F127 was exhibited in the region of 3500–500 cm –1 (Figure b). The high-intensity bands located at 1111 and 844 cm –1 were the stretching vibrations of C–O–C within Pluronic F127 . The peaks at 1283 and 2877 cm –1 were the stretching vibrations of C–H .…”

“…The high-intensity bands located at 1111 and 844 cm −1 were the stretching vibrations of C−O−C within Pluronic F127. 18 The peaks at 1283 and 2877 cm −1 were the stretching vibrations of C−H. 19 Furthermore, the bands at 956 and 1342 cm −1 were the rock and wagging of CH 2 , respectively.…”

Sustainable Synthesis of Highly Biocompatible 2D Boron Nitride Nanosheets

“…Mateti et al [ 14 ] reported that the size, shape, structure and surface chemistry directly affect BNNs biocompatibility in a dependent manner, showing that lower sizes were less biocompatible on human osteosarcoma cells. Coatings have been shown to present a high effect on the nanomaterials’ biocompatibility [ 15 ], being pluronic, a non-toxic surfactant can significantly improve the biocompatibility and reduce the cytotoxicity of the coated nanomaterials [ 15 , 39 , 40 ].…”

Preparation and characterization of zinc oxide nanoparticles incorporated tragacanth nanofibers for adsorbing fuel sulfur compounds

“…27,28 Biocompatibility, non-toxicity, availability, low-cost, UV blocking, antibacterial property, photosensitivity, transparency, and oxidation capacity constitute other merits of ZnO nanoparticles. [29][30][31] Considering the above mentioned literature, to the best of our Filtration was carried out by using a circular electrospun nanofibrous web (diameter = 2.5 cm) supported by a fine stainless mesh (pore size = 74 μm) and secured in a sulfur filtration system consisting of an Erlenmeyer flask (Navigator, USA) and a pump (Castle pumps, UK). Three hundred milliliters of the crude oil was let through the system with a rate of 100 ml h À1 .…”

“…Biocompatibility, non‐toxicity, availability, low‐cost, UV blocking, antibacterial property, photosensitivity, transparency, and oxidation capacity constitute other merits of ZnO nanoparticles 29–31 …”