Novel Poly(Diol Sebacate)s as Additives to Modify Paclitaxel Release From Poly(Lactic-co-Glycolic Acid) Thin Films

Navarro, Lucila; Mogosanu, Diana; Ceaglio, Natalia; Luna, Julio Alberto; Dubruel, Peter; Rintoul, Ignacio

doi:10.1016/j.xphs.2017.05.012

Cited by 7 publications

(3 citation statements)

References 34 publications

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“…The mouse NIH-3T3 cell line is a well-established model system of fibroblasts, largely used to study cellular responses, including those induced by biomaterials [ 33 , 34 , 35 , 36 , 37 , 38 ].…”

Section: Resultsmentioning

confidence: 99%

The Influence of the Polymer Amount on the Biological Properties of PCL/ZrO2 Hybrid Materials Synthesized via Sol-Gel Technique

et al. 2017

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Organic/inorganic hybrid materials are attracting considerable attention in the biomedical area. The sol-gel process provides a convenient way to produce many bioactive organic–inorganic hybrids. Among those, poly(e-caprolactone)/zirconia (PCL/ZrO2) hybrids have proved to be bioactive with no toxic materials. The aim of this study was to investigate the effects of these materials on the cellular response as a function of the PCL content, in order to evaluate their potential use in the biomedical field. For this purpose, PCL/ZrO2 hybrids containing 6, 12, 24, and 50 wt % of PCL were synthesized by the sol-gel method. The effects of their presence on the NIH-3T3 fibroblast cell line carrying out direct cell number counting, MTT, cell damage assays, flow cytometry-based analysis of cell-cycle progression, and immunoblotting experiments. The results confirm and extend the findings that PCL/ZrO2 hybrids are free from toxicity. The hybrids containing 12 and 24 wt % PCL, (more than 6 and 50 wt % ones) enhance cell proliferation when compared to pure ZrO2 by affecting cell cycle progression. The finding that the content of PCL in PCL/ZrO2 hybrids differently supports cell proliferation suggests that PCL/ZrO2 hybrids could be useful tools with different potential clinical applications.

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Section: Resultsmentioning

confidence: 99%

The Influence of the Polymer Amount on the Biological Properties of PCL/ZrO2 Hybrid Materials Synthesized via Sol-Gel Technique

et al. 2017

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“…Gelatin is obtained by the hydrolysis denaturation of animal connective tissues, such as skin, bone and tendons [ 20 , 21 ]. Gelatin is biocompatible, cheap and is used in various applications in the food, pharmaceutical and medical industries [ 22 , 23 , 24 ].…”

Section: Introductionmentioning

confidence: 99%

Multifactorial Effects of Gelling Conditions on Mechanical Properties of Skin-Like Gelatin Membranes Intended for In Vitro Experimentation and Artificial Skin Models

2021

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The development of new cosmetic products, skin contact medical devices, skin medicaments, wound care devices, tattooing and piercing has experienced an impressive growth in recent years. In parallel, new restrictions to in vivo experimentation in animals and humans have been widely implemented by regulatory authorities. New knowledge about alternative materials for in vitro skin-related experimentation is required to overcome these severe limitations. This paper presents a set of three 4-D surface response equations describing the mechanical properties of skin-like gelatin membranes intended for use as an alternative biomaterial for in vitro skin-related experimentation. The membranes were obtained by a sol-gel method. The novelty of this contribution is the establishment of the cross-dependency effects of key synthesis conditions on the final mechanical properties of gelatin membranes. The results of this work are useful to produce gelatin membranes with tailored mechanical properties mimicking different types of human skins. In particular, membranes with Young’s modulus of 1 MPa and maximum tensile strength of 0.85 MPa were obtained.

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“…DES strength lies in the capability to topically release one or more drugs with a controlled rate . The majority of DES provides the controlled drug delivery kinetics by means of polymeric drug‐loaded coatings . However, while the use of a polymer provides some benefits in DES performances, they should be carefully selected to meet specific chemical, biological, and regulatory requirements .…”

Section: Introductionmentioning

confidence: 99%

Adhesion properties of poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers in stent coatings

Gagliardi

2019

J of Applied Polymer Sci

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This work explores the adhesion properties of polymer solutions and thin coatings obtained by different‐composition poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers. Surface wettability, work of adhesion, and work of spreading are calculated for solutions. Increasing amounts of n‐butylmethacrylate lead to higher values of work of adhesion, measured over two stent‐like flat surfaces (AISI 316L and pyrolytic carbon). The same moiety induces the solution viscosity increase and the decrease of the work of spreading and allows obtaining more homogeneous coatings. Adhesion of thin coatings is tested in dry (cross‐cut test) and wet (immersion) conditions. Adhesion tests of coatings obtained by solvent casting reflect thermodynamic parameters evaluated for solutions. Coatings show better strength in cross‐cut tests and a prolonged adhesion in wet conditions by raising the n‐butylmethacrylate fraction. The same trends are confirmed in commercial devices. In conclusion, the study of thermodynamic solution/substrate interactions can explain coating properties. The proposed approach is worthwhile to improve deposition procedures based on polymer solutions. © 2019 Wiley Periodicals, Inc. J. Appl. Polym. Sci. 2019, 136, 47814.

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Novel Poly(Diol Sebacate)s as Additives to Modify Paclitaxel Release From Poly(Lactic-co-Glycolic Acid) Thin Films

Cited by 7 publications

References 34 publications

The Influence of the Polymer Amount on the Biological Properties of PCL/ZrO2 Hybrid Materials Synthesized via Sol-Gel Technique

The Influence of the Polymer Amount on the Biological Properties of PCL/ZrO2 Hybrid Materials Synthesized via Sol-Gel Technique

Multifactorial Effects of Gelling Conditions on Mechanical Properties of Skin-Like Gelatin Membranes Intended for In Vitro Experimentation and Artificial Skin Models

Adhesion properties of poly(methylmethacrylate‐co‐n‐butylmethacrylate) copolymers in stent coatings

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