Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone

Glisoni, Romina Julieta; Sosnik, Alejandro

doi:10.1002/mabi.201400235

Cited by 31 publications

(70 citation statements)

References 75 publications

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“…Visualization of the fluorescence was carried out with a Spectroline ENF‐280C/FE lamp (Westbury, NY) at λ = 365 nm. A glucosylated derivative of T1107 was synthesized by the microwave‐assisted ring opening reaction of T1107 with d ‐(+)‐glucono‐1,5‐lactone (Alfa Aesar, Hayesham, UK) using tin(II) 2‐ethylhexanoate (SnOct 2 , Sigma‐Aldrich) as catalyst in a Multiwave Pro Microwave Reaction System with 16HF100 rotor (Anton Paar, Ashland, VA), as described elsewhere …”

Section: Methodsmentioning

confidence: 99%

Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Melnitzer

Sosnik

2018

Adv Funct Materials

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This work describes for the first time the synthesis of hybrid drug-loaded TiO 2 /polymer amphiphilic nanoparticles of finely controlled size utilizing a simple and reproducible sol-gel process that comprises the formation of a titanium(IV)/acetone oxo-organo complex followed by its blending with an amphiphilic poly(ethylene oxide)-b-poly(propylene oxide) block copolymer in acetone and its aqueous-phase nanoprecipitation. The size of the hybrid nanoparticles is governed by the complex aging, e.g., hybrid nanoparticles display diameter between 228 and 53 nm for aging of 1 and 36 days, respectively (dynamic light scattering). In addition, they show excellent physical stability in water owing to the coating of the surface with poly(ethylene oxide) blocks of the copolymer. Conversely, polymer-free TiO 2 particles are large and precipitate fast. Incorporation of a model hydrophobic drug, nitazoxanide, to the precursor solution results in hybrid nanoparticles containing 12.9% w/w cargo that is released following a bimodal profile. High-resolution transmission electron microscopy (Titan Cubed Themis G2 300) analysis reveals the porous amorphous nanostructure of these novel hybrids and colocalization of drug and copolymer in the nanoparticle bulk. Finally, upon ultrasonication, our hybrid nanoparticles produce reactive oxygen species in vitro which paves the way for their use in sonodynamic and drug release therapies.

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Section: Methodsmentioning

confidence: 99%

Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Melnitzer

Sosnik

2018

Adv Funct Materials

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“…FTIR-ATR analysis was performed on selected samples: pure F127, fresh TiO2, Ti350, Ti375, Ti425, and Ti450 (Figure 3). Expectedly, the stretching vibration of C-H and C-O-C of PEO and PPO blocks at 2880 cm -1 and 1105 cm -1 was detected in the fresh TiO2 aerosols [54].…”

Section: Preparation Of Pure Mesoporous Tio2 With Tunable Texture Andmentioning

confidence: 92%

Aerosol-Assisted Sol-Gel Synthesis of Mesoporous TiO2 Materials, and Their Use as Support for Ru-Based Methanation Catalysts

Kim¹,

Sánchez²,

Haye³

et al. 2019

Preprint

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<div>Mesoporous TiO2 materials have been prepared by an aerosol process, which leverages on the acetic acid-mediated sol-gel chemistry and on the evaporation-induced self-assembly phenomenon to obtain materials with high specific surface area and large mesoporous volume. The obtained spherical particles are calcined to release the porosity. It is shown that the mesoscopic order can be preserved when the calcination is carried out at relatively low temperature (375 °C and below). Harsher calcination conditions lead to the progressive destruction of the mesostructured, concomitant with a progressive drop of textural properties and with the crystallization of larger anatase domains. The mesoporous TiO2 material calcined at 350°C (specific surface area = 260 m².g-1; pore volume = 0.36 cm³.-1; mean pore diameter = 5.4 nm) was selected as a promising support for preformed RuO2 nanoparticles, and subsequently annealed in air. It is shown that the presence of RuO2 nanoparticles and subsequent annealing provoke further intense modification of the texture and crystallinity of the TiO2 materials. In addition to a drop in the textural parameters, a RuO2-mediated crystallization of rutile TiO2 is highlighted at temperature as low as 250°C. After an in situ reduction in H2, the catalysts containing TiO2 rutile and relatively small RuO2 crystals showed the highest activity in the methanation of CO2. </div>

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“…24 MALDI-TOF MS spectra were recorded and the intensity is represented as a function of the m/z in the range between 2000 and 60 000 g mol À1 using the Bruker Daltonics Flex Analysis software (Bruker Daltonics GmbH) and calibrated by using commercial proteins (angiotensin, neurotensin insulin) and band g-cyclodextrins as external standards. The mass spectral data of the graft copolymers was obtained using a Ultra Flex II MALDI-TOF (Bruker Daltonik GmbH, Bremen, Germany) equipped with a pulsed nitrogen laser, operating at a wavelength of 337 nm in reflectron mode, using 2,5-dihydroxybenzoic acid as the matrix.…”

Section: Methodsmentioning

confidence: 99%

Chitosan-g-oligo(epsilon-caprolactone) polymeric micelles: microwave-assisted synthesis and physicochemical and cytocompatibility characterization

Glisoni

Molina

et al. 2015

J. Mater. Chem. B

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With the aim to produce mucoadhesive polymeric micelles for drug administration by mucosal routes, chitosan-g-oligo(epsilon-caprolactone) copolymers were synthesized by the microwave-assisted ringopening polymerization of epsilon-caprolactone using chitosan as the macroinitiator and methanesulfonic acid as the solvent, catalyst and protecting group of the amine moieties. The reaction was conducted under very mild conditions and was completed within 10 min with a monomer conversion above 90%. The grafting of oligo(epsilon-caprolactone) blocks to the free hydroxyl groups of chitosan was confirmed by ATR/FT-IR, 1 H-and 13 C-NMR, WAXD and thermal analysis (TGA/DSC). The molecular weight of the synthetic hybrid copolymers was determined by GPC and MALDI-ToF mass spectrometry. Polymeric micelles obtained by the solvent diffusion/evaporation method showed a spherical shape (TEM and AFM) with sizes between 111 and 154 nm and highly positive zeta potential (4+50 mV) (DLS). In addition, they displayed good cell compatibility in the human lung adenocarcinoma epithelial line, A549, and were readily up-taken by the cervical cancer cell line, HeLa. Results from the encapsulation of the antituberculosis drug, rifampicin, showed that the micelles had better performance than other nanocarriers previously investigated (e.g., cyclodextrins). Moreover, the micelles conserved the mucoadhesiveness displayed by pristine chitosan and are expected to transiently open tight cell junctions and lead to more prolonged residence times in mucosal tissues and greater drug bioavailability.

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Novel Poly(Ethylene Oxide)-b-Poly(Propylene Oxide) Copolymer-Glucose Conjugate by the Microwave-Assisted Ring Opening of a Sugar Lactone

Cited by 31 publications

References 75 publications

Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Hybrid Titanium Oxide/Polymer Amphiphilic Nanomaterials with Controlled Size for Drug Encapsulation and Delivery

Aerosol-Assisted Sol-Gel Synthesis of Mesoporous TiO2 Materials, and Their Use as Support for Ru-Based Methanation Catalysts

Chitosan-g-oligo(epsilon-caprolactone) polymeric micelles: microwave-assisted synthesis and physicochemical and cytocompatibility characterization

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