Novel possibility for cutaneous melanoma treatment by means of rosmarinic acid action on purinergic signaling

The P2X7 Receptor in Oncogenesis and Metastatic Dissemination: New Insights on Vesicular Release and Adenosinergic Crosstalk

“…Since then, many papers have confirmed P2X7-dependent cancer-promoting activity and associated the expression of the receptor with increased cell metabolism, neo-vascularization, and, in general, poor patient prognoses [ 1 , 14 , 54 , 55 , 56 , 57 , 58 , 59 ]. Several solid and liquid cancer types overexpress P2X7, for which P2X7-targeting drugs are potential therapeutic tools; these include acute myeloid and chronic lymphocytic leukemia [ 9 , 42 , 60 , 61 , 62 , 63 ], melanoma [ 43 , 64 , 65 ], glioma [ 66 , 67 , 68 ], neuroblastoma [ 41 , 44 , 55 , 69 , 70 ] prostate, breast, bone, and colorectal cancer [ 71 , 72 , 73 , 74 , 75 , 76 , 77 ]. As the above-cited literature demonstrate, P2X7 growth-promoting roles have been covered elsewhere; therefore, its extensive characterization is beyond the scope of the present overview.…”

The Potential of the Purinergic System as a Therapeutic Target of Natural Compounds in Cutaneous Melanoma

“…Once activated by ATP, the PI3K-AKT pathway upregulates glycolytic cascade enzymes, which promotes lactate generation and acidification of the TME. Acidification of extracellular microenvironment alters immune response and supporting cancer [5].…”

“…Regarding purinergic system modulation and the antitumor effect on cutaneous melanoma, Silva et al [5] proposed the hypothesis that rosmarinic acid, a polyphenol with antitumor effect, would be able to modulate purinergic signaling and prevent tumor progression and metastasis by two-way means: by blocking the P2X7 receptor or by antagonizing the P2Y12 receptor. Interestingly, a paper that focused on Salvia yunnanensis extract, which contains rosmarinic acid in its composition, proved the inhibition ADP-induced of rabbit platelet aggregation by binding rosmarinic acid with P2Y12R [90].…”

“…In this sense, several literatures have indicated biochemical therapy as a promising adjuvant in the CM management [4], even so it is urgent researchers to develop new options for a rise in patients' survival [1]. Therefore, many research science teams have been engaged to discover melanoma treatment and an interesting alternative to this would be to use natural substances, such as phenolic compounds that can have anticancer effects [5].…”

A new amide alkaloid induces the apoptosis of human melanoma A375 cellsviainhibition of the STAT3 signaling pathway

“…[1][2][3] The World Health Organization estimates that nearly 130 000 people are diagnosed with melanoma each year, and about 37 000 people die from this disease annually. 3 In recent years, melanoma research has been increasing, and its treatment relies mainly on the early surgical removal of malignant tissue, supplemented by chemotherapy and drug therapy, but success is limited by drug resistance, a high recurrence rate, and many side effects, 4,5 and to date, there has been no completely effective treatment. 6 Therefore, it is urgent to find a drug and method to effectively treat melanoma.…”