In this investigation, the nanocomposites were synthesized using the physical mixing technique. This technique involved adding 20% titanium dioxide (TiO2) to a combination of PMMA and PVA in terms of weight percentages. The physical properties of prepared nanocomposite have been examined by using scanning electron microscope, X-ray diffraction technique XRD, Fourier transformed infrared spectrometry (FTIR) and UV–Vis spectroscopy. XRD patterns specified that the prepared composite was mostly crystalline in nature. Scanning electron micrograph showed that TiO2 nanoparticles were covered with a polymer blend matrix. FTIR results confirmed the presence of PVA and PMMA groups on the surface of TiO2 NPs. The MTT assay method was utilized on the MSF-7 cell line in order to evaluate the potential anticancer properties of the produced components. The nanocomposites showed good activity on cancer cells.