2016
DOI: 10.18632/oncotarget.7359
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Novel potential serological prostate cancer biomarkers using CT100+ cancer antigen microarray platform in a multi-cultural South African cohort

Abstract: There is a growing need for high throughput diagnostic tools for early diagnosis and treatment monitoring of prostate cancer (PCa) in Africa. The role of cancer-testis antigens (CTAs) in PCa in men of African descent is poorly researched. Hence, we aimed to elucidate the role of 123 Tumour Associated Antigens (TAAs) using antigen microarray platform in blood samples (N = 67) from a South African PCa, Benign prostatic hyperplasia (BPH) and disease control (DC) cohort. Linear (fold-over-cutoff) and differential … Show more

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Cited by 40 publications
(36 citation statements)
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“…30 Dysregulation of this gene is detected in prostate cancer compared with benign prostatic hyperplasia. 31 However, no correlation between this gene and PaC or diabetes have been reported yet, nor the regulation interactions with miRNAs. Based on our study, CCDC33 was predicted as a target of miR-214 and up-regulated in diabetic PaC patients, suggesting this gene might serve as an oncogene during the disease progression.…”
Section: Discussionmentioning
confidence: 96%
“…30 Dysregulation of this gene is detected in prostate cancer compared with benign prostatic hyperplasia. 31 However, no correlation between this gene and PaC or diabetes have been reported yet, nor the regulation interactions with miRNAs. Based on our study, CCDC33 was predicted as a target of miR-214 and up-regulated in diabetic PaC patients, suggesting this gene might serve as an oncogene during the disease progression.…”
Section: Discussionmentioning
confidence: 96%
“…It is tempting to speculate that the CT genes associated to a better prognosis are eliciting an immune response against the tumor, which could be the reason for a better outcome in such patients. ROPN1 has been demonstrated to induce autoantibodies in patients with prostate cancer [ 43 ] and multiple myeloma [ 44 ]. Spontaneous tumor immune response was also detected for SPAG6 in sera from patients with gastric cancer, melanoma and prostate cancer [ 45 ].…”
Section: Discussionmentioning
confidence: 99%
“…It was reported as one of biomarkers to distinguish prostate cancer from 555 benign prostatic hyperplasia in patients [41]. Moreover, CALM1's mutation was reported to connect with prostate cancer and was one of verifiable biomarkers of prostate analysis using urinary shotgun proteomics [42,43]. Such a meaningful biomarker cap-turing indicates the usefulness of our network marker though more detailed analysis can be done for this network marker to retrieve more comprehensive information.…”
mentioning
confidence: 89%