Novel potential treatable traits in asthma: Where is the research taking us?

Carr, Tara F.; Peters, Michael C.

doi:10.1016/j.jacig.2022.04.001

Cited by 5 publications

(3 citation statements)

References 138 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The division of treatable traits in chronic respiratory diseases is based on three main components, namely, pulmonary-related treatable traits (airflow limitation, eosinophilic airway inflammation, airway bacterial colonization), extrapulmonary treatable traits (obesity, obstructive sleep apnea, cardiovascular disease), and lifestyle risk factors (smoking, symptom perception, adherence to treatment). 6,10,13 Treatable traits include specific clinical features, biomarkers, and certain factors that lead to a therapy that is appropriate for each individual. Patients may have several treatable traits that lead to holistic treatment.…”

Section: Treatable Traitsmentioning

confidence: 99%

Emerging Role of Precision Medicine in Diagnosis and Treatment of Chronic Respiratory Disease

Wesnawa,

Asmara,

Supadmanaba

2024

View full text Add to dashboard Cite

Precision medicine is the current approach to managing chronic respiratory diseases, especially asthma and chronic obstructive pulmonary disease (COPD). It involves the evaluation of genetic, environmental, and lifestyle variations for each patient. It requires valid and specific biomarkers obtained through genetic studies, biomolecular technology, and omics-based technology to determine targeted therapies. Asthma and COPD have heterogeneous clinical phenotype variations, and giving one standard treatment for asthma and COPD may not necessarily provide the same effectiveness to other patients. The endotype, a specific molecular mechanism in disease pathogenesis, is essential in phenotype variation. The role of precision medicine in asthma and COPD is to determine endotypes through specific biomarkers and to provide specific targeted therapy for achieving personalized treatment in each patient. The application of precision medicine not only provides precise diagnosis and treatment but also enables early detection in individuals at risk and prevention of progression and exacerbation in asthma and COPD.

show abstract

Section: Treatable Traitsmentioning

confidence: 99%

Emerging Role of Precision Medicine in Diagnosis and Treatment of Chronic Respiratory Disease

Wesnawa,

Asmara,

Supadmanaba

2024

View full text Add to dashboard Cite

show abstract

“…This lesson has been learned in interstitial lung disease, for which it is now well appreciated that different disease processes resulting in lung fibrosis have different trajectories and do not respond to the same antifibrotic or antiinflammatory therapies ( 1 ). In chronic obstructive pulmonary disease and asthma, attention has progressively been focused in both stable disease and exacerbations on different robust phenotypes and/or “treatable traits” on the basis of clinical and laboratory features and/or responsiveness to therapy ( 2 , 3 ). These subgroupings are both relevant to clinical practice and also almost certainly underlaid by differences in pathological processes, with implications for future therapeutic advances.…”

mentioning

confidence: 99%

What Changes in Research Focus Do We Need to Advance Care for Patients with Bronchiectasis?

Waterer

2024

Am J Respir Crit Care Med

View full text Add to dashboard Cite

“…Asthma may be classified as Type 2 or non-Type 2 asthma ; the last one is characterized by difficult-to-treat asthma (Carr and Peters, 2022;Fraga-Silva et al, 2023).…”

Section: Asthmamentioning

confidence: 99%

Role of S100A9 in the comorbidity asthma and acute pneumonia

Boko

View full text Add to dashboard Cite

A pneumonia causada por Streptococcus pneumoniae pode melhorar ou exacerbar a asma. A exacerbação na comorbidade asma e pneumonia pode ser decorrente da indução de inflamação neutrofílica, que é caracterizada como asma mais grave e de difícil tratamento. S100A9 é uma alarmina que atua como sinal de perigo endógeno e promove o recrutamento de neutrófilos. Essa alarmina está envolvida na imunopatologia de diferentes doenças que afetam os pulmões, como a asma e a pneumonia.Nossa hipótese é de que a pneumonia aguda induzida por S. pneumoniae exacerba a inflamação pulmonar na asma por meio da indução de S100A9, que contribui para a inflamação neutrofílica e a produção de armadilhas extracelulares de neutrófilos (NET).Camundongos C57BL/6 Wild Type (WT) e deficientes para a expressão de S100A9 (S100A9 -/-) foram sensibilizados e desafiados com ovalbumina e infectados ou não com S. pneumoniae durante o desafio. Em camundongos WT, a infecção pneumocócica concomitante à exposição ao alérgeno resultou em aumento significativo no recrutamento de neutrófilos no fluido do lavado broncoalveolar (BALF), acompanhado por aumento do infiltrado de leucócitos perivasculares e peribronquiais, secreção de S100A9 e produção de NET nos pulmões em comparação com os camundongos WT expostos apenas ao alérgeno. Durante a comorbidade, camundongos S100A9 -/exibiram redução significativa nas concentrações de CXCL1, uma quimiocina que atrai neutrófilos, e do influxo de neutrófilos no BALF. Além disso, durante a comorbidade, camundongos S100A9 -/apresentaram aumento na morte de neutrófilos. A intervenção farmacológica com tasquinimod ou azeliragon, inibidores da sinalização S100A9, ou com BB Cl-amidina, um inibidor de NET, protegeu os camundongos da inflamação neutrofílica e da produção de NET durante a comorbidade asma e pneumonia aguda.Nossos resultados forneceram evidências de que S100A9 e NET podem ser alvos terapêuticos na asma grave que cursa com inflamação neutrofílica decorrente de pneumonia.

show abstract

Novel potential treatable traits in asthma: Where is the research taking us?

Cited by 5 publications

References 138 publications

Emerging Role of Precision Medicine in Diagnosis and Treatment of Chronic Respiratory Disease

Emerging Role of Precision Medicine in Diagnosis and Treatment of Chronic Respiratory Disease

What Changes in Research Focus Do We Need to Advance Care for Patients with Bronchiectasis?

Role of S100A9 in the comorbidity asthma and acute pneumonia

Contact Info

Product

Resources

About