Novel potentiometric application for the determination of pantoprazole sodium and itopride hydrochloride in their pure and combined dosage form

Ragab, M. T.; El-Rahman, Mohamed K. Abd; Ramadan, Nesrin K.; El‐Ragehy, Nariman A.; El‐Zeany, Badr A.

doi:10.1016/j.talanta.2015.01.045

Cited by 44 publications

(26 citation statements)

References 29 publications

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“…However, PVC must be used with a plasticizer or solvent mediator for two reasons: the first one is to prevent membrane cracking by giving it much elasticity. The second one is the solubilization of the ion exchanger and thereby modifying its distribution constant .…”

Section: Resultsmentioning

confidence: 99%

“…Nowadays electrochemical techniques specially, ion selective electrodes (ISEs), has made great progress and achievement in the field of pharmaceutical analysis. This can be owed to its simplicity, rapidity, portability, lower energy consumption and its applicability to colored and turbid solutions . Searching the literature, no attempt was found for the selective determination of LD in presence of its toxic metabolite DMA by ISE.…”

Section: Introductionmentioning

confidence: 99%

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Novel Green Potentiometric Method for the Determination of Lidocaine Hydrochloride and its Metabolite 2, 6‐Dimethylaniline; Application to Pharmaceutical Dosage Form and Milk

et al. 2018

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Sustainable chemistry has attracted the attention of scientists during the last decades owing to the great advantages encountered by its application. These include: waste reduction, energy conservation and substitution of hazardous substances with more eco‐friendly ones. Following this approach, a new sensitive and selective membrane sensor was developed and investigated for the determination of lidocaine hydrochloride (LD) and its carcinogenic metabolite 2,6‐dimethylaniline (DMA). Several polyvinyl chloride (PVC) based sensors were tried using different plasticizers as well as different cation exchangers. The best response was achieved upon using dioctylphthalate (DOP) as solvent mediator and phosphotungstate (PT) as cation exchanger. LD was selectively determined at pH 6 without interference from its carcinogenic metabolite, while DMA that had been reported to be the toxic inactive metabolite of LD secreted in the milk was determined in the milk at pH 2. Fast, stable Nernstian responses were achieved by the proposed sensors over a concentration range of 2.66×10−5 M to 1×10−2 M for both LD and DMA. The method was validated according to the IUPAC recommendations and was successfully applied for the determination of LD in pure form and pharmaceutical dosage form, whereas DMA was successfully determined in pure form and spiked milk samples.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Novel Green Potentiometric Method for the Determination of Lidocaine Hydrochloride and its Metabolite 2, 6‐Dimethylaniline; Application to Pharmaceutical Dosage Form and Milk

et al. 2018

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“…26,27 RESEARCH ARTICLE The results in Table 2 also demonstrate that the anodized EPPG has a better response characteristics compared with the other carbon-based electrodes (CP 23 and GC 24,25 ). Compared with the chemically modified electrodes, [28][29][30][31][32] the EPPG electrode exhibited a higher analytical performance especially in terms of detection limit and sensitivity (Table 2). These results indicate that by carefully selecting the best electrode among different available carbon-based structures, it is possible to develop a simple analytical method based on direct electro-oxidation of analyte molecules on the electrode surface and to achieve analytical performance comparable or even better than the methods based on time-consuming and complicated electrode surface modification procedures by metals, 28 metal oxides, 32 or polymers.…”

Section: Comparison Of the Developed Methods With Other Electrochemicamentioning

confidence: 99%

“…These results indicate that by carefully selecting the best electrode among different available carbon-based structures, it is possible to develop a simple analytical method based on direct electro-oxidation of analyte molecules on the electrode surface and to achieve analytical performance comparable or even better than the methods based on time-consuming and complicated electrode surface modification procedures by metals, 28 metal oxides, 32 or polymers. [29][30][31] …”

Section: Comparison Of the Developed Methods With Other Electrochemicamentioning

confidence: 99%

“…So far, direct electro-oxidation of pantoprazole at the carbonbased electrodes has been reported based on carbon paste (CP) 23 and glassy carbon (GC) 24,25 electrodes. Except carbonbased electrodes, hanging mercury drop (HMD) 26,27 and chemi-cally modified electrodes [28][29][30][31][32] have been also used for pantoprazole electroanalysis. At the first part of this paper, electrooxidation of pantoprazole at the CP, GC, edge-plane pyrolytic graphite (EPPG), basal-plane pyrolytic graphite (BPPG), and some nanostructured carbon-based materials such as CNTmodified GC, graphene oxide (GO)-modified GC, and carbon black (CB)-modified GC electrodes are comparatively evaluated .…”

Section: Introductionmentioning

confidence: 99%

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Anodized Edge-plane pyrolytic graphite for electroanalysis of pantoprazole in tablet dosage forms and human urine samples

Hadi

Ehsani

2016

S.Afr.j.chem.

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Electroanalytical parameters of different graphitic carbon-based electrode materials were compared to select the best one for the pantoprazole electroanalysis. Such parameters include sensitivity, repeatability, residual background current, and signal-tobackground current ratio of the analytical response and such electrodes include conventional carbon-based electrodes such as glassy carbon (GC), carbon paste, edge-plane pyrolytic graphite (EPPG), and basal-plane pyrolytic graphite electrodes and film-coated modified GC electrodes with graphitic carbon-based materials such as carbon nanotube, nanographene, carbon black and graphite powder. The EPPG electrode, after applying a simple electrochemical anodization, showed more acceptable analytical performances compared with the other electrodes. Raman spectroscopy was employed to study the surface structural changes that occurred dring the anodic activation. Calibration plot with a good linearity was obtained in the concentration range of 0.2-25 and 0.02-8.5 µM, and the detection limit was estimated to be 0.055 and 0.0041 µM using cyclic voltammetry and differential pulse voltammetry techniques, respectively. Finally, the electrochemically activated EPPG electrode was used successfully for the determination of pantoprazole in tablet dosage forms and human urine samples with satisfactory results. KEYWORDSEdge-plane pyrolytic graphite, graphitic carbon-based electrodes, anodic activation, pantoprazole electroanalysis, nanographene, carbon nanotube.

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Biomedizinische Anwendungen von Calixarenen: Stand der Wissenschaft und Perspektiven

Pan

Guo

2020

Angewandte Chemie

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Calixarene (CAs) stellen die dritte Generation supramolekularer Wirtsstrukturen dar und sind eine der am häufigsten untersuchten makrocyclischen Gerüststrukturen. Sie bieten aufgrund ihrer einfachen Modifikation (fast) unbegrenzte Möglichkeiten, um große Molekülbibliotheken als Materialbasis für vielfältige biomedizinische Anwendungen zu etablieren. Darüber hinaus beteiligen sich CAs und ihre Derivate an verschiedenen nichtkovalenten Interaktionen zur einfachen Erkennung von Gaststrukturen, einschließlich bioaktiver Moleküle, und sind auch wichtige Bausteine für die Herstellung supramolekularer Architekturen. Im Hinblick auf ihre molekularen Erkennungs‐ und Selbstorganisationseigenschaften werden CAs in großem Umfang in der Biosensorik, dem Bioimaging und im Wirkstoff‐/Gentransport eingesetzt. Weiterhin weisen einige CA‐Derivate biologische Aktivitäten auf und können daher als neue Therapeutika eingesetzt werden. Wir fassen hier die vielfältigen biomedizinischen Anwendungen von CAs zusammen, einschließlich der In‐vitro‐Diagnostik (Biosensorik), In‐vivo‐Diagnostik (Bioimaging) und Therapie.

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Novel potentiometric application for the determination of pantoprazole sodium and itopride hydrochloride in their pure and combined dosage form

Cited by 44 publications

References 29 publications

Novel Green Potentiometric Method for the Determination of Lidocaine Hydrochloride and its Metabolite 2, 6‐Dimethylaniline; Application to Pharmaceutical Dosage Form and Milk

Novel Green Potentiometric Method for the Determination of Lidocaine Hydrochloride and its Metabolite 2, 6‐Dimethylaniline; Application to Pharmaceutical Dosage Form and Milk

Anodized Edge-plane pyrolytic graphite for electroanalysis of pantoprazole in tablet dosage forms and human urine samples

Biomedizinische Anwendungen von Calixarenen: Stand der Wissenschaft und Perspektiven

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