Novel predictive scoring system for intravenous immunoglobulin resistance helps timely intervention in Kawasaki disease: the Chinese experience

Abstract

Background: Approximately 10–20% of patients with Kawasaki disease (KD) are non-responsive to intravenous immunoglobulin treatment, placing them at higher risk of developing coronary heart lesions. Early detection of non-responsiveness is crucial to curtail this risk; however, the applicability of existing predictive scoring systems is limited to the Japanese population. Our study aimed to identify a predictive scoring system for intravenous immunoglobulin resistance in KD that is specific to the Chinese population. We aimed to assess the utility of three commonly used risk scoring systems in predicting intravenous immunoglobulin resistance and compare them to the newly developed predictive scoring system. Methods: A total of 895 patients with KD were enrolled in this retrospective review and divided into two groups: intravenous immunoglobulin responders and non-responders. Clinical and laboratory variables were compared between the two groups. Multivariable logistic regression models were used to construct a new scoring system. The utility of the existing and new scoring systems was assessed and compared using the area under the receiver operating characteristic curve. Results: Albumin levels, percentage of neutrophils, and hemoglobin were independent predictors of resistance by logistic regression analysis. The new predictive scoring system was derived with improved sensitivity (60.5%) and specificity (87.8%). The area under the receiver operating characteristic curve was 0.818. Conclusion: This study developed a novel risk scoring system for predicting resistance to intravenous immunoglobulin treatment in KD that is specific to the Chinese population. Although this new model requires further validation, it may be useful for improving prognostic outcomes and reducing the risk of complications associated with KD.

Novel Predictive Scoring System for Intravenous Immunoglobulin Resistance Helps Timely Intervention in Kawasaki Disease: The Chinese Experience

“…We would like to thank Editage ( www.editage.cn ) for English language editing. At the same time, we also want to thank Research Square (www.researchsquare.com) for posting this manuscript as a preprint ( https://doi.org/10.21203/rs.3.rs-2724038/v1 ) [ 27 ]. This study was supported by the National Key R&D Program of China (grant number: 2021YFC2702000), the National Natural Science Foundation of China (grant number: 81202345, 81771762), Project of the Jiangsu Provincial Health Commission (grant number: M2021080), and Project of the Nanjing Municipal Health Commission (grant number: YKK21144).…”