Novel preventive mechanisms of vitamin B6 against inflammation, inflammasome, and chronic diseases

Zhang, Peipei; Suda, Takafumi; Suidasari, Sofya; Kumrungsee, Thanutchaporn; Katô, Norihisa

doi:10.1016/b978-0-12-811907-5.00032-4

Cited by 17 publications

(19 citation statements)

References 57 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The immediate administration of vitamin B6 in mice contributed towards neutrophil reduction in liver and helped in diminishing the oxidative damage to protein and lipids in liver [43]. Vitamin B6 also modulates the kynurenine pathway, sphingosine-1-phosphate, and nuclear factor-kappa B thus lowering inflammation [44]. Hence, the mechanism of vitamin B6 is via regulating the oxidative stress in peripheral organs i.e.…”

Section: Discussionmentioning

confidence: 99%

Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice

et al. 2020

View full text Add to dashboard Cite

Background: Myrin®-p Forte is an anti-tuberclosis agent that can cause hepatic injuries in clinical settings. Maytenus royleanus (Celastraceae) is a medicinal plant, possesses antioxidant and anticancer activities. The hepatoprotective effect of the methanol extract of Maytenus royleanus leaves (MEM) against Myrin®-p Forte induced hepatotoxicity in mice was investigated.Methods: Mice were randomly parted into six groups (n = 6). Fixed-dose combination of Myrin®-p Forte (13.5 mg/ kg Rifampicin, 6.75 mg/kg Isoniazid, 36.0 mg/kg Pyrazinamide and 24.8 mg/kg Ethambutol; RIPE] was administered for 15 days to induce liver injury. In treatment groups MEM (200 mg/kg and 400 mg/kg doses) and Vitamin B6 (180mg/kg) were administered prior to RIPE. Control group received 2% DMSO. Serum liver function tests, DNA damage, tissue antioxidant enzymes and histopathological alterations were studied. HPLC analysis was performed to determine the chemical composition using standard compounds.(Continued on next page) Results: The quercitin, gallic acid, luteolin, viteixin, apigenin, kaempherol, hyperoside and myricetin contents of all samples were determined by reverse-phase HPLC. Quercetin (0.217 mg/g dry weight) and luteolin (0.141 mg/g dry weight) were the major flavonoids identified in MEM. Myrin®-p Forte markedly (p < 0.05) deteriorated lipid profile and upregulated the concentration of LDH, AST, ALP, ALT and γ-GT in serum along with DNA fragmentation (37.13 ± 0.47%) and histopathological injuries in hepatic tissues of mice compared with the control group. Myrin®-p Forte increased (p < 0.001) lipid peroxidation and H 2 O 2 while decreased (p < 0.001) the activity level of CAT, SOD, POD, GPx, GST, GSR, γ-GT and GSH. Co-administration of MEM (200 mg/kg; 400 mg/kg) or the vitamin B6 (180 mg/ kg) to Myrin®-p Forte administered mice significantly ameliorated LDL, cholesterol, HDL and triglyceride content. Furthermore, MEM dose dependently corrected serum liver function tests, decrease % DNA fragmentation (17.82 ± 0.35 and 7.21 ± 0.32 respectively), DNA damage. MEM treated protect RIPE induced oxidative damage by enhancing antioxidants to oxidants balance. Histological examination comprehends biochemical findings. Conclusion: The antioxidant effects of MEM exerted the hepatoprotective potential against the Myrin®-p Forte induced hepatotoxicity in mice.

show abstract

Section: Discussionmentioning

confidence: 99%

Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice

et al. 2020

View full text Add to dashboard Cite

show abstract

“…This pathway produces anti-inflammatory molecules such as kynurenine [ 5 ]. Research shows that an optimized level of kynureninase with its cofactor can inhibit progression of cancer in vivo [ 37 ]. An end-metabolite of kynurenic axis, 8-hydroxyquialdic acid has anti-proliferative and anti-migratory effects on colorectal cancer cells.…”

Section: Vitamin B6 and Diseasesmentioning

confidence: 99%

“…An end-metabolite of kynurenic axis, 8-hydroxyquialdic acid has anti-proliferative and anti-migratory effects on colorectal cancer cells. Kynureninase activity is regulated by the level of PLP [ 37 ]. The influence of vitamin B6 on the development of cancer is also a popular topic for meta-analysis.…”

Section: Vitamin B6 and Diseasesmentioning

confidence: 99%

Vitamin B6 in Health and Disease

2021

View full text Add to dashboard Cite

Vitamin B6 is a fascinating molecule involved in the vast majority of changes in the human body because it is a coenzyme involved in over 150 biochemical reactions. It is active in the metabolism of carbohydrates, lipids, amino acids, and nucleic acids, and participates in cellular signaling. It is an antioxidant and a compound with the ability to lower the advanced glycation end products (AGE) level. In this review, we briefly summarize its involvement in biochemical pathways and consider whether its deficiency may be associated with various diseases such as diabetes, heart disease, cancer, or the prognosis of COVID-19.

show abstract

“…Furthermore, PLP is also associated with circulating CRP and other oxidative stress markers that are known to reduce superoxide radical effects in endothelial cells. Also, low vitamin B6 concentrations decrease the glutathione, alter the antioxidant defense system and lead to inflammation, a crucial mechanism in subclinical atherosclerosis [105,106].…”

Section: Vitamin B6mentioning

confidence: 99%

The Effect of Vitamin Supplementation on Subclinical Atherosclerosis in Patients without Manifest Cardiovascular Diseases: Never-ending Hope or Underestimated Effect?

et al. 2020

View full text Add to dashboard Cite

Micronutrients, especially vitamins, play an important role in the evolution of cardiovascular diseases (CVD). It has been speculated that additional intake of vitamins may reduce the CVD burden by acting on the inflammatory and oxidative response starting from early stages of atherosclerosis, when the vascular impairment might still be reversible or, at least, slowed down. The current review assesses the role of major vitamins on subclinical atherosclerosis process and the potential clinical implications in patients without CVD. We have comprehensively examined the literature data for the major vitamins: A, B group, C, D, and E, respectively. Most data are based on vitamin E, D and C supplementation, while vitamins A and B have been scarcely examined for the subclinical atherosclerosis action. Though the fundamental premise was optimistic, the up-to-date trials with vitamin supplementation revealed divergent results on subclinical atherosclerosis improvement, both in healthy subjects and patients with CVD, while the long-term effect seems minimal. Thus, there are no conclusive data on the prevention and progression of atherosclerosis based on vitamin supplementation. However, given their enormous potential, future trials are certainly needed for a more tailored CVD prevention focusing on early stages as subclinical atherosclerosis.

show abstract

Novel preventive mechanisms of vitamin B6 against inflammation, inflammasome, and chronic diseases

Cited by 17 publications

References 57 publications

Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice

Phytochemical analysis and Evaluation of hepatoprotective effect of Maytenus royleanus leaves extract against anti-tuberculosis drug induced liver injury in mice

Vitamin B6 in Health and Disease

The Effect of Vitamin Supplementation on Subclinical Atherosclerosis in Patients without Manifest Cardiovascular Diseases: Never-ending Hope or Underestimated Effect?

Contact Info

Product

Resources

About