Novel production and characterization of porous calcium phosphate suitable for bone tissue engineering applications

Stergioudi, F.; Choleridis, A.; Paulidou, E.; Smyrnaios, Emmanouil; Michailidis, Nikolaos

doi:10.1016/j.ceramint.2014.11.058

Cited by 5 publications

(6 citation statements)

References 30 publications

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“…The production process for the calcium phosphate foams consisting of four stages: mixing, compaction, dissolution and sintering. The production process is thoroughly described in [18]. In summary, the HAp and alumina powders are mixed with the sugar particles at a pre-specified weight ratio depending on the desired alumina addition and the desired final porosity of bioceramic foam.…”

Section: Production Methods Of Bioceramic Foamsmentioning

confidence: 99%

“…The removal of the sugar from the green compact particles was achieved by water leaching. Subsequently sintering in atmospheric conditions was performed at 1250 °C for 4 h. Details for the optimum thermal cycle used in this study so as to prevent the collapse of the macro-pore network due to sintering conditions can be found in [18].…”

Section: Production Methods Of Bioceramic Foamsmentioning

confidence: 99%

“…Nevertheless, the flake-like morphology of the precipitating phase on the surface resembles the apatite form found in bones and indicates enhanced bioactivity of the foam. It was safely deduced that the interaction between Ca +2 and PO4 −3 ions both derived from the dissolution of the TCP phase (Ca 3 (PO) 4 ) resulted in the deposition of flake-like crystals of bone-like apatite in the calcium phosphate foam [18,23].…”

Section: Biodegradation/dissolution Studiesmentioning

confidence: 99%

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Production, characterization and properties of open-cell calcium phosphate foams reinforced with alumina

et al. 2019

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In this study, tailored made open-cell calcium phosphate foams reinforced with alumina were fabricated by employing a dissolution-sintering process, using crystalline raw cane sugar as a water-leachable material. The effect of the alumina addition in the 3D morphology and in the microstructure of the produced calcium phosphate-based foams was examined. Preliminary in vitro bio-dissolution studies were performed to obtain an initial indication for the suitability of these composite bioceramic foams as implant materials. The mechanical properties of the produced composite calcium phosphate foams were also evaluated. It was found that the addition of small amount of alumina (5 wt%) resulted in a microstructural alteration affecting both the 3D geometry of the produced bioceramic foams and the morphology of the precipitated apatite during the biodegradation tests. The addition of alumina resulted in considerable enhancement of the mechanical strength of the bioceramic foam when the porosity was above 70%. The produced calcium phosphatebased composite foams (with alumina reinforcement) are suitable for biomedical applications.

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Section: Production Methods Of Bioceramic Foamsmentioning

confidence: 99%

Section: Production Methods Of Bioceramic Foamsmentioning

confidence: 99%

Section: Biodegradation/dissolution Studiesmentioning

confidence: 99%

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Production, characterization and properties of open-cell calcium phosphate foams reinforced with alumina

et al. 2019

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“…Polymeric sponges, pore-making substances such as poly methyl methacrylate [12,27] or polystyrene beads [28], cane sugar [21], polyethylene glycol-polyvinyl alcohol hydrogel [10,29], and gas-foaming [30] have been reported. However, each method has its disadvantages and limitations.…”

Section: Introductionmentioning

confidence: 99%

“…In order to obtain porous BCP bioceramic scaffolds, template method and foaming process are usually selected [9,21,22]. For the purpose of hard tissue regeneration, BCP bioceramic scaffolds with both macro and micro pores are found favorable.…”

Section: Introductionmentioning

confidence: 99%

Fabrication, characterization and cellular biocompatibility of porous biphasic calcium phosphate bioceramic scaffolds with different pore sizes

Tang

Mao

Liu

et al. 2016

Ceramics International

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Bioactivity and mechanical stability of Ti–6Al–4V implants superplastically embedded with hydroxyapatite in rats

et al. 2017

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In this in vivo study, Sprague Dawley (SD) rats were used to investigate the bioactivity as well as the microstructural and mechanical properties of Ti-6Al-4V samples embedded with hydroxyapatite (HA) using two different coating methods-superplastic embedment (SPE) and superplastic deformation (SPD). The HA layer thickness for the SPE and SPD samples increased from 249.1 ± 0.6 nm to 874.8 ± 13.7 nm, and from 206.1 ± 5.8 nm to 1162.7 ± 7.9 nm respectively, after 12 weeks of implantation. The SPD sample exhibited much faster growth of newly formed HA compared to SPE. The growth of the newly formed HA was strongly dependent on the degree of HA crystallinity in the initial HA layer. After 12 weeks of implantation, the surface hardness value of the SPE and SPD samples decreased from 661 ± 0.4 HV to 586 ± 1.3 HV and from 585 ± 6.6 HV to 425 ± 86.9 HV respectively. The decrease in surface hardness values was due to the newly formed HA layer that was more porous than the initial HA layer. However, the values were still higher than the substrate surface hardness of 321 ± 28.8 HV. Wear test results suggest that the original HA layers for both samples were still strongly intact, and to a certain extent the newly grown HA layers also were strongly bound with the original HA layers. This study confirms the bioactivity and mechanical stability of the HA layer on both samples in vivo.

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Novel production and characterization of porous calcium phosphate suitable for bone tissue engineering applications

Cited by 5 publications

References 30 publications

Production, characterization and properties of open-cell calcium phosphate foams reinforced with alumina

Production, characterization and properties of open-cell calcium phosphate foams reinforced with alumina

Fabrication, characterization and cellular biocompatibility of porous biphasic calcium phosphate bioceramic scaffolds with different pore sizes

Bioactivity and mechanical stability of Ti–6Al–4V implants superplastically embedded with hydroxyapatite in rats

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