2017
DOI: 10.5603/fhc.a2017.0019
|View full text |Cite
|
Sign up to set email alerts
|

Novel prognostic molecular factors: a quantum leap in the field of chronic lymphocytic leukemia

Abstract: Cytogenetic lesions do not completely explain clinical heterogeneity of chronic lymphocytic leukemia (CLL). The 2016 revision of the World Health Organization classification 2008 indicated that molecular lesions of TP53, NOTCH1, SF3B1 and BIRC3 have potential clinical relevance and could be integrated into an updated risk profile. The negative clinical implications of TP53 disruptions are well constituted and patients with these mutations should be considered for novel, small molecule signal transduction inhib… Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...
1

Citation Types

0
1
0

Year Published

2021
2021
2021
2021

Publication Types

Select...
1

Relationship

1
0

Authors

Journals

citations
Cited by 1 publication
(1 citation statement)
references
References 85 publications
0
1
0
Order By: Relevance
“…SF3B1 is a core component of the spliceosome, a complex of five small nuclear ribonucleoproteins RNA (snRNPs), the splicing machinery involved in the process of RNA editing through the removal of introns in protein-encoding genes [45]. The product of the SF3B1 gene is considered as an essential component that catalyses the removal of intronic sequences and ligates the exons into mature, functional mRNA [46].…”
Section: Sf3b1 Mutationmentioning
confidence: 99%
“…SF3B1 is a core component of the spliceosome, a complex of five small nuclear ribonucleoproteins RNA (snRNPs), the splicing machinery involved in the process of RNA editing through the removal of introns in protein-encoding genes [45]. The product of the SF3B1 gene is considered as an essential component that catalyses the removal of intronic sequences and ligates the exons into mature, functional mRNA [46].…”
Section: Sf3b1 Mutationmentioning
confidence: 99%