Novel Prognostic Signature for Acute Myeloid Leukemia: Bioinformatics Analysis of Combined CNV-Driven and Ferroptosis-Related Genes

Han, Chunjiao; Zheng, Jianbo; Li, Fangfang; Guo, Wei; Cai, Chunquan

doi:10.3389/fgene.2022.849437

Cited by 11 publications

(7 citation statements)

References 41 publications

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“…All these subgroups could be classified as high or low risk according to NRG score, and there was a significant difference in OS rates between NRG score groups ( p < 0.0001), which indicated that NRG characteristics performed well in the stratified analysis and demonstrated the robustness of the prognostic value of NRG characteristics. Further, we compared NRG score with other signatures in recently published studies 17–19 . These signatures were genes associated with ferroptosis, immunity, and the most significant prognosis respectively.…”

Section: Resultsmentioning

confidence: 99%

“…Further, we compared NRG score with other signatures in recently published studies. [17][18][19] These signatures were genes associated with ferroptosis, immunity, and the most significant prognosis respectively. Compared to them, the area under the five-year ROC curve of the NRG score was highest in the training and test set patients (Figure S3G).…”

Section: Applicability and Superiority Of Nrg Scorementioning

confidence: 99%

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Identification of a signature based on non‐apoptotic regulatory cell death to improve prognosis prediction in acute myeloid leukaemia

Zheng

Weng

et al. 2022

Br J Haematol

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Acute myeloid leukaemia (AML) is a heterogeneous haematologic malignancy characterized by proliferation of nonnormally differentiated myeloblasts or progranulocytes. 1 Five-year survival rates for patients with AML are disappointing at 28.3%, and most cases remain in remission with frequent relapses resulting in a poor prognosis. 2 Recent evidence suggests that the identification of new biomarkers of AML contributes to a better understanding of the molecular basis of the disease and is useful in the detection, diagnosis, prognosis and monitoring of AML and in predicting the likelihood of each individual. 3 Our study aims to construct a new prognostic model and improve risk-adapted treatment for patients.Regulatory cell death (RCD), a fundamental biological phenomenon of cells, has an irreplaceable impact on the onset and development of many processes of life and disease. RCD plays an important role in the stability of homeostasis in vivo, in the development of multiple systems, and the evolution of organisms. 4 Based on different morphological, biochemical, immunological and genetic characteristics, RCD is divided into two categories: apoptotic and non-apoptotic. Non-apoptotic RCD can be subdivided into autophagy, ferroptosis, pyroptosis, necroptosis, and the recently identified cuproptosis. 5,6 Research on apoptosis has been conducted for more than 30 years. However, therapeutic agents targeting apoptosis regulators such as apoptosis-associated cystathionases or B-cell lymphoma 2 (BCL-2) family proteins have been ineffective in anti-tumour therapy. 7 In contrast,

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Section: Resultsmentioning

confidence: 99%

Section: Applicability and Superiority Of Nrg Scorementioning

confidence: 99%

Identification of a signature based on non‐apoptotic regulatory cell death to improve prognosis prediction in acute myeloid leukaemia

Zheng

Weng

et al. 2022

Br J Haematol

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“…In another study, investigators have identified and verified seven ferroptosis-related lncRNA signatures (AP001266.2, AC133961.1, AF064858.3, AC007383.2, AC008906.1, AC026771.1, and KIF26B-AS1) with independent prognostic value in patients with AML (Table 1) [35]. In summary, we conducted and validated a novel ferroptosisrelated prognostic model for outcome prediction and risk stratification in AML, with great potential to guide individualized treatment strategies in the future [31,[36][37][38].…”

Section: Leukemiamentioning

confidence: 99%

Ferroptosis in Leukemia: Lessons and Challenges

Song¹,

Zhang²

2023

Biochemistry

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Ferroptosis is a newly defined programmed cell death (PCD) process with the hallmark of the accumulation of iron-dependent lipid peroxidation, which is more immunogenic over apoptosis. Ferroptosis shows great potential as a therapeutic target against acute kidney injury (AKI), cancers, cardiovascular diseases, neurodegenerative diseases, and hepatic diseases. Accumulating evidence has highlighted that ferroptosis plays an unneglectable role in regulating the development and progression of multiple pathologies of leukemia including acute myeloid leukemia (AML), chronic myeloid leukemia (CML), acute lymphoblastic leukemia (ALL), and chronic lymphocytic leukemia (CLL). Herein, we focus on the state-of-the-art renewal in the relationship of ferroptosis with leukemia. Meanwhile, this chapter further highlights the iron, lipid and amino acid metabolism, as well as ferroptosis-based molecular mechanisms. Collectively, we summarize the contribution of ferroptosis to the pathogenesis of leukemia and discuss ferroptosis as a novel therapeutic target for different types of leukemia.

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“…Interestingly, many FRG signatures are associated with immune-related pathways and immune cell infiltration predicted by CIBERSORTx gene-expression profiling analyses, which suggests that ferroptosis has relevance in anti-tumor immune responses and potentially in immunotherapy in leukemia. In addition to FRGs’ expression levels, their methylation status [ 180 ] and copy number variations [ 181 ] have also been reported to have prognostic significance. One group studying the correlation of long non-coding RNAs (lncRNAs) and FRGs identified ferroptosis-related lncRNA signatures that predict the prognosis of AML [ 182 ].…”

Section: Ferroptosis In Leukemiamentioning

confidence: 99%

Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia

Akiyama

Carter

Andreeff

et al. 2023

Cells

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Ferroptosis is a mode of cell death regulated by iron-dependent lipid peroxidation. Growing evidence suggests ferroptosis induction as a novel anti-cancer modality that could potentially overcome therapy resistance in cancers. The molecular mechanisms involved in the regulation of ferroptosis are complex and highly dependent on context. Therefore, a comprehensive understanding of its execution and protection machinery in each tumor type is necessary for the implementation of this unique cell death mode to target individual cancers. Since most of the current evidence for ferroptosis regulation mechanisms is based on solid cancer studies, the knowledge of ferroptosis with regard to leukemia is largely lacking. In this review, we summarize the current understanding of ferroptosis-regulating mechanisms with respect to the metabolism of phospholipids and iron as well as major anti-oxidative pathways that protect cells from ferroptosis. We also highlight the diverse impact of p53, a master regulator of cell death and cellular metabolic processes, on the regulation of ferroptosis. Lastly, we discuss recent ferroptosis studies in leukemia and provide a future perspective for the development of promising anti-leukemia therapies implementing ferroptosis induction.

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Novel Prognostic Signature for Acute Myeloid Leukemia: Bioinformatics Analysis of Combined CNV-Driven and Ferroptosis-Related Genes

Cited by 11 publications

References 41 publications

Identification of a signature based on non‐apoptotic regulatory cell death to improve prognosis prediction in acute myeloid leukaemia

Identification of a signature based on non‐apoptotic regulatory cell death to improve prognosis prediction in acute myeloid leukaemia

Ferroptosis in Leukemia: Lessons and Challenges

Molecular Mechanisms of Ferroptosis and Updates of Ferroptosis Studies in Cancers and Leukemia

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