Novel Promises of Nanotechnology for Tissue Regeneration

Sadik, Abir El

doi:10.5772/25865

Cited by 1 publication

(3 citation statements)

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“…39 Specifically, biomimetic nanomaterials have been reported to promote cells proliferation and tissue regeneration owing to decreased immune response. 334 Nanobiomaterials possess a higher surface area to volume ratio, surface energy, multifunctionality, and improved surface catalytic activity in comparison with the conventional macroscale biomaterials. 334 In order to control cellular functions and ECM production in natural tissues, nanoscale protein interactions are indispensable.…”

Section: Poloxamer Blockmentioning

confidence: 99%

“…334 Nanobiomaterials possess a higher surface area to volume ratio, surface energy, multifunctionality, and improved surface catalytic activity in comparison with the conventional macroscale biomaterials. 334 In order to control cellular functions and ECM production in natural tissues, nanoscale protein interactions are indispensable. The tunable and versatile physiochemical properties of nanobiomaterials could enhance their interactions with biological systems at molecular levels.…”

Section: Poloxamer Blockmentioning

confidence: 99%

“…Nanotechnological approaches enable the development of proper hierarchical structures to better mimic the native ECM . Specifically, biomimetic nanomaterials have been reported to promote cells proliferation and tissue regeneration owing to decreased immune response . Nanobiomaterials possess a higher surface area to volume ratio, surface energy, multifunctionality, and improved surface catalytic activity in comparison with the conventional macroscale biomaterials .…”

Section: Biological Performance Of Nanostructured Hydrogels With Stim...mentioning

confidence: 99%

See 2 more Smart Citations

Smart Polymeric Hydrogels for Cartilage Tissue Engineering: A Review on the Chemistry and Biological Functions

Eslahi

Abdorahim²,

Simchi³

2016

Biomacromolecules

217

123

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Stimuli responsive hydrogels (SRHs) are attractive bioscaffolds for tissue engineering. The structural similarity of SRHs to the extracellular matrix (ECM) of many tissues offers great advantages for a minimally invasive tissue repair. Among various potential applications of SRHs, cartilage regeneration has attracted significant attention. The repair of cartilage damage is challenging in orthopedics owing to its low repair capacity. Recent advances include development of injectable hydrogels to minimize invasive surgery with nanostructured features and rapid stimuli-responsive characteristics. Nanostructured SRHs with more structural similarity to natural ECM up-regulate cell-material interactions for faster tissue repair and more controlled stimuli-response to environmental changes. This review highlights most recent advances in the development of nanostructured or smart hydrogels for cartilage tissue engineering. Different types of stimuli-responsive hydrogels are introduced and their fabrication processes through physicochemical procedures are reported. The applications and characteristics of natural and synthetic polymers used in SRHs are also reviewed with an outline on clinical considerations and challenges.

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Section: Poloxamer Blockmentioning

confidence: 99%

Section: Poloxamer Blockmentioning

confidence: 99%