Novel Pyrimidin‐2‐yl‐benzylidene imines and 2‐[(pyrimidin‐ylimino)‐methyl]‐phenoles and their Antibacterial Activity

Abstract

Some new Pyrimidin‐2‐yl‐benzylidene‐imines are synthesized by catalytic reactions of aromatic aldehydes and corresponding 2‐Aminopyrimidines. Condensation of Benzaldehyde 1a and 2‐Aminopyrimidines 2(a,b) gave pyrimidin‐2‐yl‐benzylidene imines 3(a,b). By condensation of salycilaldehyde 1b and 2‐Aminopyridines 2(a,b), corresponding 2‐[(pyrimidin‐ylimino)‐methyl]‐phenoles 3(c,d) were synthesized. The antibacterial activity of products 3(a–d) were investigated and results were submitted for their activities against Escherichia coli, Clebsiella and Staphylococcus aureus.Compound 3a showed emphatic bactericide activity against Staphylococcus aureus. Compounds were more active against. Light activity against Escherichia coli exhibited compounds 3a and 3c, whereas 3d exhibited the strongest activity against Clebsiella. In general there was a direct positive correlation between increasing concentration of the compound and antibacterial activity