Novel pyrimidine derivatives by sonication and traditional thermal methods

Abstract

A series of bis-compounds (2) were synthesized by condensing dihydro-1,3-(disubstituted)phenyl-2-thioxopyrimidine-4,6(1H,5H)-dione with hippuric acid in presence of acetic anhydride. The compound (2) on further treatment with aromatic amine afforded dihydropyrimidine (3) through an eco-friendly procedure by sonication. The sonication method reduces time and gives higher yields, and also the effluent produced is free from hazardous contamination and organic by-products. The novel pyrimidines were also synthesized by traditional methods for comparison purposes and sonication method was found to be superior. Structures of the synthesized compounds have been elucidated on the basis of elemental analysis and spectral data.

Ultrasound-assisted one-pot multi-component synthesis of 2-pyrrolidinon-3-olates catalyzed by Co3O4@SiO2core–shell nanocomposite

“…According to Table 3, the aryl aldehydes with electronwithdrawing groups, such as NO 2 and Cl, in p-position reacted with 2-aminobenzothiazole, dimethyl acetylenedicarboxylate and morpholine/piperidine very smoothly, while the reactants with electron-donating groups, such as hydroxy and methoxy, proceeded with the longer reaction time along with the lower product yields. In addition, the sterically hindered aldehydes reacted more slowly in comparison with the unhindered ones.…”

“…Furthermore, MCRs are easy to perform, inexpensive, quick, energy efficient and experimental procedures are relatively simple (1). Recently, the application of ultrasonic irradiation in chemical syntheses has received much attention (2)(3)(4)(5). On the other hand, designing MCRs under ultrasonic irradiation is another attractive area in synthetic organic chemistry.…”

Review of Microwave-Assisted Synthesis of Benzo-Fused Six-MemberedN,N-Heterocycles

“…For all these reasons, the various possibilities offered by the microwave technology are particularly attractive where fast, high-yielding protocols and the avoidance or facilitation of purification are highly desirable. [5][6] Wherever domestic microwave oven, which do not provide a scientifically adequate level of reproducibility, was used by the authors is mentioned in the present paper.…”

Benign Approaches for the Microwave‐assisted Synthesis of Five‐membered 1,2‐N,N‐heterocycles

“…In many cases, the classic syntheses provide reliable access to heterocyclic compounds; however, they are simply no longer acceptable by current environmental and safety standards. For all these reasons, the various possibilities offered by the microwave technology are particularly attractive where fast, high‐yielding protocols and the avoidance or facilitation of purification are highly desirable . Wherever a domestic microwave oven, which does not provide a scientifically adequate level of reproducibility, was used by the authors is mentioned in the present article.…”