Novel QuEChERS-ultra-performance liquid chromatography–atmospheric-pressure chemical ionization tandem mass spectrometry method for the simultaneous determination of vitamin D and vitamin K in vitamin-fortified nanoemulsions

Kim, Tae‐Eun; Yoo, Gayoung; Lee, Hyo-Geun; Kim, Bum-Keun; Jang, Hae Won

doi:10.1016/j.foodchem.2022.133009

Cited by 9 publications

(1 citation statement)

References 39 publications

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“…An ideal sample preparation technique for food analysis applications should remove interfering substances as completely as possible and be compatible with a wide range of sample matrices (Vickers, 2017 ). Although traditional extraction methods, such as liquid–liquid extraction and solid‐phase extraction, are widely used for sample pretreatment (Titato & Lanças, 2005 ), they exhibit certain drawbacks, which has inspired the development of alternative pretreatment methods like microextraction (Ibrahim et al, 2017 ; Kim et al, 2022 ).…”

Section: Introductionmentioning

confidence: 99%

Determination of vitamin K encapsulated into lipid nanocarriers by dispersive liquid–liquid microextraction combined with liquid chromatography–atmospheric pressure chemical ionization–tandem mass spectrometry

Yoo

Kim

Lee

et al. 2022

Food Science & Nutrition

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Dispersive liquid–liquid microextraction was used in conjunction with liquid chromatography–atmospheric pressure chemical ionization–tandem mass spectrometry to quantitate vitamins K1 and K2 in vitamin‐fortified emulsions, and vital microextraction parameters were optimized using response surface methodology coupled with Box–Behnken design. Under optimal microextraction conditions, highly linear ( R 2 > .999) calibration curves were obtained for both vitamins in a broad concentration range (1–1000 μg/L), and vitamin recoveries exceeded 90%. The detection and quantitation limits equaled 1.89 and 5.72 μg/L for vitamin K1, respectively, and 5.00 and 15.15 μg/L for vitamin K2, respectively. When applied to vitamin‐K‐loaded nanoemulsions and solid lipid nanoparticles, the developed method achieved excellent results, outperforming the currently employed Korean Food Code method, and therefore holding great promise for the quantitation of vitamin K in vitamin‐fortified food products.

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