Novel quinazolinones and enniatins from <i>Fusarium</i> <i>lateritium</i> Nees

Tsantrizos, Youla S.; Xu, Xiao-Jin; Sauriol, Françoise; Hynes, Rosemary C.

doi:10.1139/v93-176

Cited by 33 publications

(11 citation statements)

References 10 publications

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“…In the first category, the metabolites produced by CM and still present in CMFS were including 4‐hydroxybenzoic acid, cyclohexaneacetic acid, verrucosapyrone A, [36] botryosulfuranols A−C, fumarylalanine, 4‐hydroxymellein, (−)‐( R )‐mellein, 5‐hydroxymellein, leptosphaerin, 10,11‐dehydrocurvularin, 7‐methylguanosine, phelligridin B, hemisecalonic acid B, dehydrogliotoxin, [37] citridone C, [38] benzylpenicillin, islandic acid I, [39] and trypacidin [40] . The metabolites, which are produced by FS and can be detected in CMFS, were including hymeglusin, [41] lateropyrone, [42] asperfumoid, acremonone H, cyclosporin A, cyclosporin E, and wyerol [43] …”

Section: Resultsmentioning

confidence: 99%

Dynamics of Chemical Diversity during Co‐Cultures: An Integrative Time‐Scale Metabolomics Study of Fungal Endophytes Cophinforma mamane and Fusarium solani

Triastuti

Haddad

Barakat

et al. 2021

Chemistry & Biodiversity

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A rapid and efficient metabolomic study of Cophinforma mamane and Fusarium solani co‐cultivation in time‐series based analysis was developed to study metabolome variations during their fungal interactions. The fungal metabolomes were studied through the integration of four metabolomic tools: MS‐DIAL, a chromatographic deconvolution of liquid‐chromatography‐mass spectrometry (LC/MS); MS‐FINDER, a structure‐elucidation program with a wide range metabolome database; GNPS, an effective method to organize MS/MS fragmentation spectra, and MetaboAnalyst, a comprehensive web application for metabolomic data analysis and interpretation. Co‐cultures of C. mamane and F. solani induced different patterns of metabolite production over 10 days of incubation and induced production of five de novo compounds not occurring in monocultures. These results emphasize that co‐culture in time‐frame analysis is an interesting method to unravel hidden metabolome in the investigation of fungal chemodiversity.

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Section: Resultsmentioning

confidence: 99%

Dynamics of Chemical Diversity during Co‐Cultures: An Integrative Time‐Scale Metabolomics Study of Fungal Endophytes Cophinforma mamane and Fusarium solani

Triastuti

Haddad

Barakat

et al. 2021

Chemistry & Biodiversity

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“…From the AcOEt extract of the fungus strain DM815, we obtained one new (1) and fourteen known compounds (2 -15) by various chromatographic methods (Figure 1). The known compounds were identified to be 2',3'-dihydrosorbicillin (2), [10] trichopyrone (3), [13] 10,11,16,17-tetrahydrobislongiquinolide (4), [14] epitetrahydrotrichodimer ether (5), [2] (9'R)-tetrahydrotrichodimer ether (6), [15] trichodimerol (7), [16] dihydrotrichodimerol (8), [17] tetrahydrotrichodimerol (9), [17] trichobisvertinol A (10), [4] dihydrotrichodermolide (11), [18] chrysogine (12), [19] citreohybridonol (13), [20] andrastin A (14), [21] and (3E)-3-[(1H-imidazol-4-yl) methylidene]-6-[(1H-indol-3-yl)methyl]piperazine-2,5dione (15) [22] by comparing their spectroscopic data, which can be found in Supplementary Figures S11-S59 and Tables S2 2). The key HMBC of H-2' (δ H 2.97) with C-1' (δ C 203.6) and C-5 (δ C 106.5) and of H-6 (δ H 8.36) with C-2 (δ C 163.5), C-4 (δ C 162.9), C-5 (δ C 106.5) and C-1' (δ C 203.6) determined the location of the dihydrosorbyl residue at the β position of the pyridine ring in 1 (Figure 2).…”

Section: Resultsmentioning

confidence: 99%

Isolation and Characterization of Anti‐Inflammatory Sorbicillinoids from the Mangrove‐Derived Fungus Penicillium sp. DM815

Ding¹,

Wang²,

Li³

et al. 2021

Chemistry & Biodiversity

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Marine derived fungus has gained increasing ground in the discovery of novel lead compounds with potent biological activities including anti-inflammation. Here, we first report the characterization of one new sorbicillinoid (1) and fourteen known compounds (2 -15) from the ethyl acetate (AcOEt) extract of a cultured mangrove derived fungus Penicillium sp. DM815 by UV, IR, HR ESI-Q-TOF MS, and NMR spectra. We then evaluated the anti-inflammatory effects of eleven sorbicillinoids (1 -11) using cultured macrophage RAW264.7 cells. The results show that compound 9, and to a lesser degree compound 5, significantly inhibited the Gramnegative bacteria lipopolysaccharide (LPS)-induced upregulation of the inducible nitric oxide synthase (iNOS). Consistently, compounds 5 and 9 significantly reduced the level of nitric oxide (NO), the product of iNOS, induced by LPS. We further show that these two compounds dose-dependently inhibited LPS-triggered iNOS expression and NO production, but had no effect on proliferation of RAW264.7 cells in the presence of LPS. In conclusion, our study identifies novel and known sorbicillinoids as potent anti-inflammatory agents, holding the promise of developing novel anti-inflammation treatment in the future.

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“…The role of this fungus as a plant pathogen was intensively studied, and its mycotoxins showed antimicrobial activity (Tsantrizos et al 1993 ;May et al 2000 ). Fusarium species are the basis of commercial fungal agents for the biological control of weeds and diseases (Butt et al 2001 ).…”

Section: Introductionmentioning

confidence: 99%

Phylogenetic analysis of the genus Fusarium and their antifungal activity against wood-decay and sapstain fungi

Lee¹,

Hong²,

Lee³

et al. 2012

Holzforschung

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Microorganism-based biological protections are alternatives to chemical treatments. Worldwide, Fusarium species are important plant pathogens, and their mycotoxins are antimicrobial. In this study, 18 Fusarium strains isolated in Korea have been investigated. Nine Fusarium species, including two unknown species, were identified based on their genotypic characteristics. Among the identified species, Fusarium armeniacum and Fusarium commune were observed for the first time in Korea. The antifungal activity of Fusarium crude extracts was assessed by growth inhibition against two wood-decay fungi and three sapstain fungi. Most Fusarium strain extracts revealed strong antifungal activity against wood-decay fungi. Strains of the unknown Fusarium sp. 2, which was found in wood samples, showed strong antifungal activity against all wood-decay and sapstain fungi tested in this study.

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Novel quinazolinones and enniatins from Fusarium lateritium Nees

Cited by 33 publications

References 10 publications

Dynamics of Chemical Diversity during Co‐Cultures: An Integrative Time‐Scale Metabolomics Study of Fungal Endophytes Cophinforma mamane and Fusarium solani

Dynamics of Chemical Diversity during Co‐Cultures: An Integrative Time‐Scale Metabolomics Study of Fungal Endophytes Cophinforma mamane and Fusarium solani

Isolation and Characterization of Anti‐Inflammatory Sorbicillinoids from the Mangrove‐Derived Fungus Penicillium sp. DM815

Phylogenetic analysis of the genus Fusarium and their antifungal activity against wood-decay and sapstain fungi

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