Novel R-(+)-limonene-based thiosemicarbazones and their antitumor activity against human tumor cell lines

Evaluation of Antiproliferative and Antileishmanial Activities of R-(+)- limonene-derived 2-Amino-5-aryl-1,3,4-thiadiazoles

“…O isotiocianato terpênico obtido é submetido a uma reação de condensação com hidrazina que leva a formação da tiossemicarbazida monoterpênica 2. 27 As tiossemicarbazonas 3a-3j são obtidas pela condensação mediante catálise ácida da tiossemicarbazida 2 com benzaldeído e derivados substituídos. 27 análogos (4c, 4d, 4e, 4f, 4h e 4i) foram moderadamente ativos frente a todas as células tumorais testadas, não apresentando seletividade significativa.…”

Crystal structure of 3-benzyl-1-[(1,2,3,4-tetrahydronaphthalen-1-ylidene)amino]thiourea

“…For the antitumour activities of thiosemicarbazides, see: Vandresen et al (2014); Xie et al (2014); Gan et al (2014). For the synthesis of the title compound, see: Mague et al (2014) 2.…”

Synthesis, Molecular Modeling, and Biological Evaluation of Novel Chiral Thiosemicarbazone Derivatives as Potent Anticancer Agents

“…When a chiral compound is synthesized in several steps, it can be important for practical and economic reasons to introduce the proper stereochemistry at an early stage. This can be achieved starting from chiral building blocks that are enantiomerically pure and have functionalities that allow them to be transformed into the desired product . According to this approach, chiral amines can be considered convenient starting materials in the synthesis of chiral thiosemicarbazones because they are commercially available, and generally accessible in two enantiomeric forms.…”