Novel radiolabeled ligand, Para-chloro-2-[<sup>18</sup>F]fluoroethyletomidate (CETO) compared to [<sup>11</sup>C]metomidate-PET (MTO) for the lateralisation of primary aldosteronism (PA)

Goodchild, Emily; Senanayake, Russell; Wu, Xilin; Bashari, Waiel; Salsbury, Jackie; Argentesi, Giulia; O'Toole, Samuel; MacFarlane, James; Laycock, Kate; Gillett, Dan; Boros, István; Aigbirhio, Franklin I.; Sadhev, Anju; Bird, Nicholas J.; Hader, Stefan; Warnes, Victoria; Cruickshank, Kennedy; Cheow, Heok; Drake, William; Gurnell, Mark

doi:10.1530/endoabs.86.op2.1

EJEA

2022

DOI: 10.1530/endoabs.86.op2.1

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Novel radiolabeled ligand, Para-chloro-2-[¹⁸F]fluoroethyletomidate (CETO) compared to [¹¹C]metomidate-PET (MTO) for the lateralisation of primary aldosteronism (PA)

Emily Goodchild¹,

Russell Senanayake²,

Xilin Wu³

et al.

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Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

Azizan

Goodchild

et al. 2023

Nat Genet

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Aldosterone-producing adenomas (APAs) are the commonest curable cause of hypertension. Most have gain-of-function somatic mutations of ion channels or transporters. Herein we report the discovery, replication and phenotype of mutations in the neuronal cell adhesion gene CADM1. Independent whole exome sequencing of 40 and 81 APAs found intramembranous p.Val380Asp or p.Gly379Asp variants in two patients whose hypertension and periodic primary aldosteronism were cured by adrenalectomy. Replication identified two more APAs with each variant (total, n = 6). The most upregulated gene (10- to 25-fold) in human adrenocortical H295R cells transduced with the mutations (compared to wildtype) was CYP11B2 (aldosterone synthase), and biological rhythms were the most differentially expressed process. CADM1 knockdown or mutation inhibited gap junction (GJ)-permeable dye transfer. GJ blockade by Gap27 increased CYP11B2 similarly to CADM1 mutation. Human adrenal zona glomerulosa (ZG) expression of GJA1 (the main GJ protein) was patchy, and annular GJs (sequelae of GJ communication) were less prominent in CYP11B2-positive micronodules than adjacent ZG. Somatic mutations of CADM1 cause reversible hypertension and reveal a role for GJ communication in suppressing physiological aldosterone production.

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Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

Azizan

Goodchild

et al. 2023

Nat Genet

Self Cite

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show abstract

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Novel radiolabeled ligand, Para-chloro-2-[¹⁸F]fluoroethyletomidate (CETO) compared to [¹¹C]metomidate-PET (MTO) for the lateralisation of primary aldosteronism (PA)

Cited by 1 publication

References 0 publications

Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

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Novel radiolabeled ligand, Para-chloro-2-[18F]fluoroethyletomidate (CETO) compared to [11C]metomidate-PET (MTO) for the lateralisation of primary aldosteronism (PA)

Cited by 1 publication

References 0 publications

Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

Somatic mutations of CADM1 in aldosterone-producing adenomas and gap junction-dependent regulation of aldosterone production

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Novel radiolabeled ligand, Para-chloro-2-[¹⁸F]fluoroethyletomidate (CETO) compared to [¹¹C]metomidate-PET (MTO) for the lateralisation of primary aldosteronism (PA)