Novel Rat Model of Methicillin-Resistant Staphylococcus aureus–Infected Silicone Breast Implants

Abstract

The model successfully induced persistent breast implant infection. Free planktonic MRSA produced in situ biofilm on silicone implants. Biofilm infection has milder manifestations than free planktonic MRSA infection, which has higher rates of systemic infections and death when compared with either isolated biofilm infection or free planktonic MRSA infection without implant. Vancomycin has limited effect against mature biofilm.

Microbial biofilm in human health - an updated theoretical and practical insight

“…In a rat model developed by Arad E. et al for silicone breast implants contaminated with methicillin-resistant S. aureus (MRSA), biofilm infection proved to be persistent, asymptomatic and with high resistance to vancomycin (27).…”

“…For example for analyzing biofilms by CLSM, researchers have used ultrasonic units for a gentle removal of biofilms from joint prostheses, internal fixation devices, vascular prostheses, cardiac pacemakers and defibrillators, dental implants, neurosurgical shunts or breast implants (27).…”

“…Scanning electron microscopy (SEM) is cited among the techniques allowing optimal visualization of the biofilm bacteria within the EPS, as well as of their direct attachment to the respective surface (16,20,27,31).…”

Antibacterial effect of electrospun polycaprolactone/polyethylene oxide/vancomycin nanofiber mat for prevention of periprosthetic infection and biofilm formation

“…The danger of MRSA infections result from not only the emergence of multidrug resistance but also the occurrence of strong biofilm-forming bacteria [15]. [16].…”

Alleviation of capsular formations on silicone implants in rats using biomembrane-mimicking coatings

“…It has been hypothesized that capsular contracture might result from excessive foreign body reactions on the silicone surface, gel http bleed, dust, glove powder, etc., or by subclinical infection by normal skin flora (usually by Staphylococcus epidermidis) [8][9][10][11][12]. The foreign body reaction include, in particular, the inflammatory process and exaggerated scar response to a foreign prosthetic material [13,14].…”