Novel ratiometric xanthene-based probes for protease detection

A synthetic three-fluorophore system with two enzymatically cleavable linkers has been developed for the simultaneous detection of two proteases in a mixture. The probe was designed to afford single excitation/triple emission ratiometric detection through a fluorescence change during the cleavage of a peptide linker. The developed assays were verified for trypsin and chymotrypsin as the model enzymes.

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Perspective on chymotrypsin detection

Shi

Liu

Cui

et al. 2020

New J. Chem.

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Novel ratiometric xanthene-based probes for protease detection

Cited by 4 publications

References 39 publications

Synthesis, spectroscopic and computational evaluation of a xanthene-based fluorogenic derivatization reagent for the determination of primary amines

Synthesis, spectroscopic and computational evaluation of a xanthene-based fluorogenic derivatization reagent for the determination of primary amines

A novel three-fluorophore system as a ratiometric sensor for multiple protease detection

Perspective on chymotrypsin detection

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