Novel recombinant BCG and DNA-vaccination against tuberculosis in a cynomolgus monkey model

Quantitative Comparison of Active and Latent Tuberculosis in the Cynomolgus Macaque Model

“…Few tuberculosis studies with macaques (most commonly, vaccine studies) have been able to identify quantitative differences between groups of monkeys (17,27,31). Other studies of macaques with M. tuberculosis infection either have not been able to detect a difference in bacterial burden (18) or did not report differences in bacterial burden between experimental groups (16,22,29). This is surprising, given that most of these studies involved high-dose M. tuberculosis infection and are likely to demonstrate more dramatic differences than our low-dose model of infection.…”

Monkey Models of Tuberculosis: Lessons Learned

“…A series of subsequent investigations were dedicated to macaque research to assess novel TB vaccines and drugs, as well as to gain an understanding of the pathogenesis of M. tuberculosis infection and reactivation. Figures 2 and 3 abridge the RM (13,(26)(27)(28)(29)(30)(31)(32)(33)(34)(35)(36)(37)(38)(39)(40)(41)(42)(43) and CM (10,15,25,(42)(43)(44)(45)(46)(47)(48)(49)(50)(51)(52)(53)(54)(55)(56)(57)(58)(59) models of experimental M. tuberculosis infection after the Golden Age, from 2001 to 2014.…”

“…Between 2005 and 2012, three reported studies using CM models evaluated the efficacy of TB vaccines that had been tested previously with smaller animal models, including guinea pigs and mice (44,45). The first project evaluated the efficacy of the 72f recombinant BCG vaccine and HASP65 plus interleukin-12 (IL-12)/HVJ vaccine (44), which another team of investigators also tested later in Osaka, Japan (45). Both research investigations showed that the recombinant BCG vaccines were more effective than BCG alone.…”

Development of therapeutic and prophylactic vaccine against Tuberculosis using monkey and transgenic mice models

“…Yoko Kita, 1 Masaji Okada, 1, * Toshihiro Nakajima, 2 Noriko Kanamaru, 1 Satomi Hashimoto, 1 Tetsuji Nagasawa,…”